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CDC42 CDC42 MAPK1 MAPK1 MAP3K7 MAP3K7 WASF1 WASF1 TJP1 TJP1 FYN FYN TGFBR2 TGFBR2 PTPRM PTPRM CSNK2A2 CSNK2A2 WASF2 WASF2 INSR INSR TCF7L1 TCF7L1 CTNNA2 CTNNA2 SNAI2 SNAI2 ERBB2 ERBB2 AFDN AFDN NECTIN1 NECTIN1 ACP1 ACP1 CTNNB1 CTNNB1 WAS WAS NECTIN4 NECTIN4 ACTB ACTB LEF1 LEF1 LOC111170713 LOC111170713 IQGAP1 IQGAP1 FARP2 FARP2 ACTN1 ACTN1 TCF7L2 TCF7L2 FGFR1 FGFR1 PTPRB PTPRB PTPRF PTPRF RHOA RHOA LMO7 LMO7 PTPN6 PTPN6 PARD3 PARD3 SSX2IP SSX2IP LOC111178986 LOC111178986 SMAD3 SMAD3 MET MET WASL WASL SMAD4 SMAD4 ACTN4 ACTN4 NECTIN2 NECTIN2 CDH1 CDH1 YES1 YES1 TCF7 TCF7 RAC3 RAC3 MAPK3 MAPK3 CTNNA1 CTNNA1 ACTG1 ACTG1 CTNNA3 CTNNA3 RAC1 RAC1 BAIAP2 BAIAP2 CTNND1 CTNND1 FER FER SRC SRC CREBBP CREBBP CSNK2A1 CSNK2A1 RAC2 RAC2 EGFR EGFR NLK NLK EP300 EP300 SNAI1 SNAI1 IGF1R IGF1R PTPN1 PTPN1 NECTIN3 NECTIN3 TGFBR1 TGFBR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (559 aa)
TJP1Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1914 aa)
FYNTyrosine-protein kinase. (537 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PTPRMReceptor-type tyrosine-protein phosphatase mu isoform X2. (1531 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (601 aa)
CTNNA2Catenin alpha-2. (865 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
AFDNAfadin isoform X1. (1794 aa)
NECTIN1Nectin-1. (416 aa)
ACP1Low molecular weight phosphotyrosine protein phosphatase isoform X1. (158 aa)
CTNNB1Catenin beta-1. (781 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
NECTIN4Nectin-4. (509 aa)
ACTBActin, cytoplasmic 1. (375 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
LOC111170713Lymphocyte antigen 6 complex locus protein G5b isoform X2. (299 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1657 aa)
FARP2FERM, RhoGEF and pleckstrin domain-containing protein 2 isoform X1. (1116 aa)
ACTN1Alpha-actinin-1 isoform X2. (914 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
PTPRBReceptor-type tyrosine-protein phosphatase beta isoform X1. (2213 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1917 aa)
RHOATransforming protein RhoA. (193 aa)
LMO7LIM domain only protein 7 isoform X1. (1646 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1356 aa)
SSX2IPAfadin- and alpha-actinin-binding protein isoform X1. (618 aa)
LOC111178986LOW QUALITY PROTEIN: catenin alpha-1-like. (908 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ACTN4Alpha-actinin-4 isoform X5. (933 aa)
NECTIN2Nectin-2 isoform X1. (539 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
YES1Tyrosine-protein kinase. (541 aa)
TCF7Transcription factor 7 isoform X1. (415 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
CTNNA1Catenin alpha-1. (906 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CTNNA3Catenin alpha-3. (944 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2. (522 aa)
CTNND1Catenin delta-1 isoform X1. (961 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
SRCTyrosine-protein kinase. (562 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
EP300Histone acetyltransferase p300. (2420 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
NECTIN3Nectin-3 isoform X1. (549 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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