STRINGSTRING
MYL12B MYL12B CLDN5 CLDN5 LOC111163074 LOC111163074 CDC42 CDC42 MYH11 MYH11 NF2 NF2 LOC111162912 LOC111162912 RUNX1 RUNX1 TJP1 TJP1 IGSF5 IGSF5 LOC111162959 LOC111162959 AMOT AMOT ROCK2 ROCK2 CLDN14 CLDN14 PCNA PCNA MAP2K7 MAP2K7 ARHGEF18 ARHGEF18 WHAMM WHAMM PRKACA PRKACA RAB13 RAB13 CRB3 CRB3 EZR EZR ERBB2 ERBB2 ARHGEF2 ARHGEF2 JAM3 JAM3 PARD6G PARD6G AFDN AFDN LLGL1 LLGL1 RDX RDX PPP2R1B PPP2R1B MAPK10 MAPK10 CLDN25 CLDN25 TJP3 TJP3 MAP3K5 MAP3K5 LOC111167107 LOC111167107 RAB8A RAB8A MICALL2 MICALL2 WAS WAS CGN CGN F11R F11R AMOTL1 AMOTL1 HCLS1 HCLS1 MSN MSN LOC111170121 LOC111170121 ACTB ACTB BVES BVES DLG3 DLG3 MAPK9 MAPK9 CLDN2 CLDN2 RAP2C RAP2C MAPK8 MAPK8 LOC111171851 LOC111171851 PPP2R2D PPP2R2D DLG1 DLG1 MPP4 MPP4 STK11 STK11 CLDN1 CLDN1 PPP2CB PPP2CB CLDN23 CLDN23 CDK4 CDK4 PRKAG3 PRKAG3 ACTN1 ACTN1 MPP5 MPP5 MYL6B MYL6B PRKAG1 PRKAG1 CLDN11 CLDN11 TUBA4A TUBA4A PRKCI PRKCI JAM2 JAM2 CLDN8 CLDN8 PRKCE PRKCE CACNA1D CACNA1D TIAM1 TIAM1 LOC111173597 LOC111173597 CLDN19 CLDN19 MYL6 MYL6 MPDZ MPDZ LOC111174050 LOC111174050 LOC111176042 LOC111176042 JUN JUN RHOA RHOA CLDN10 CLDN10 CLDN17 CLDN17 LOC111174051 LOC111174051 MAGI1 MAGI1 ACTR3B ACTR3B TUBA8 TUBA8 TJP2 TJP2 PRKAG2 PRKAG2 PRKAA2 PRKAA2 PATJ PATJ YBX3 YBX3 EPB41L4B EPB41L4B PARD3 PARD3 RAB8B RAB8B CLDN16 CLDN16 NEDD4 NEDD4 PRKACB PRKACB ITGB1 ITGB1 AMOTL2 AMOTL2 CFTR CFTR CGNL1 CGNL1 NEDD4L NEDD4L RAP1A RAP1A VASP VASP ACTN4 ACTN4 TJAP1 TJAP1 RAPGEF2 RAPGEF2 PPP2R2C PPP2R2C PRKAB2 PRKAB2 PPP2R1A PPP2R1A MARVELD3 MARVELD3 CLDN15 CLDN15 PARD6A PARD6A ROCK1 ROCK1 SYMPK SYMPK SLC9A3R1 SLC9A3R1 CLDN3 CLDN3 MYH14 MYH14 PPP2CA PPP2CA ACTG1 ACTG1 LLGL2 LLGL2 RAC1 RAC1 CLDN4 CLDN4 ACTR3 ACTR3 RAPGEF6 RAPGEF6 ARHGAP17 ARHGAP17 CCND1 CCND1 HSPA4 HSPA4 PPP2R2B PPP2R2B MYL9 MYL9 SRC SRC SYNPO SYNPO DLG2 DLG2 GATA4 GATA4 CLDN6 CLDN6 CLDN7 CLDN7 OCLN OCLN MARVELD2 MARVELD2 CLDN9 CLDN9 PPP2R2A PPP2R2A ACTR2 ACTR2 MAP3K1 MAP3K1 PARD6B PARD6B MYL2 MYL2 MYH10 MYH10 PRKAA1 PRKAA1 PRKCZ PRKCZ PRKAB1 PRKAB1 MYH9 MYH9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYL12BMyosin regulatory light chain 12B. (172 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
LOC111163074Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (415 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MYH11Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
NF2Merlin isoform X3. (619 aa)
LOC111162912Myosin regulatory light chain 12B. (171 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
TJP1Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1914 aa)
IGSF5Immunoglobulin superfamily member 5 isoform X1. (375 aa)
LOC111162959Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
AMOTAngiomotin isoform X1. (1081 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18 isoform X1. (1420 aa)
WHAMMWASP homolog-associated protein with actin, membranes and microtubules. (808 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RAB13Ras-related protein Rab-13. (203 aa)
CRB3Protein crumbs homolog 3. (123 aa)
EZREzrin. (586 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1032 aa)
JAM3Junctional adhesion molecule C. (301 aa)
PARD6GPartitioning defective 6 homolog gamma. (371 aa)
AFDNAfadin isoform X1. (1794 aa)
LLGL1Lethal(2) giant larvae protein homolog 1 isoform X1. (1063 aa)
RDXRadixin isoform X2. (604 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CLDN25LOW QUALITY PROTEIN: putative claudin-25. (230 aa)
TJP3Tight junction protein ZO-3 isoform X1; Belongs to the MAGUK family. (922 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa)
LOC111167107T-cell surface glycoprotein CD1b-2-like. (333 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
MICALL2MICAL-like protein 2 isoform X1. (953 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
CGNCingulin isoform X1. (1194 aa)
F11RJunctional adhesion molecule A. (299 aa)
AMOTL1Angiomotin-like protein 1 isoform X1. (956 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
MSNMoesin isoform X1. (579 aa)
LOC111170121Tubulin alpha chain-like 3; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (286 aa)
ACTBActin, cytoplasmic 1. (375 aa)
BVESBlood vessel epicardial substance. (360 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (849 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
RAP2CRas-related protein Rap-2c. (183 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LOC111171851Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (425 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
MPP4MAGUK p55 subfamily member 4; Belongs to the MAGUK family. (639 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (293 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
ACTN1Alpha-actinin-1 isoform X2. (914 aa)
MPP5MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa)
MYL6BMyosin light chain 6B. (213 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
JAM2Junctional adhesion molecule B isoform X1. (350 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
PRKCEProtein kinase C. (746 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X3. (1606 aa)
LOC111173597Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
MYL6Myosin light polypeptide 6 isoform X2. (151 aa)
MPDZMultiple PDZ domain protein isoform X1. (2071 aa)
LOC111174050Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
LOC111176042Ras-related protein Rap-2a-like. (200 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
LOC111174051Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
MAGI1Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1. (1484 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (556 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (496 aa)
TJP2Tight junction protein ZO-2 isoform X2; Belongs to the MAGUK family. (1187 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (566 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PATJinaD-like protein isoform X1. (1900 aa)
YBX3Y-box-binding protein 3 isoform X1. (371 aa)
EPB41L4BBand 4.1-like protein 4B isoform X1. (901 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1356 aa)
RAB8BRas-related protein Rab-8B isoform X1. (207 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
AMOTL2Angiomotin-like protein 2 isoform X1. (775 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
CGNL1Cingulin-like protein 1. (1299 aa)
NEDD4LE3 ubiquitin-protein ligase NEDD4-like isoform X1. (1244 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (384 aa)
ACTN4Alpha-actinin-4 isoform X5. (933 aa)
TJAP1Tight junction-associated protein 1 isoform X1. (559 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X1. (1651 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X2. (272 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
MARVELD3MARVEL domain-containing protein 3. (384 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SYMPKSymplekin. (1273 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
MYH14Myosin-14 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
LLGL2Lethal(2) giant larvae protein homolog 2 isoform X1. (1057 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
RAPGEF6Rap guanine nucleotide exchange factor 6 isoform X1. (1606 aa)
ARHGAP17Rho GTPase-activating protein 17 isoform X1. (875 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HSPA4Heat shock 70 kDa protein 4. (840 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (545 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
SRCTyrosine-protein kinase. (562 aa)
SYNPOSynaptopodin isoform X1. (901 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
GATA4Transcription factor GATA-4 isoform X1. (437 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
MARVELD2MARVEL domain-containing protein 2 isoform X2. (559 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1 isoform X1. (1508 aa)
PARD6BPartitioning defective 6 homolog beta. (372 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
MYH10Myosin-10 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2023 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
MYH9Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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