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TBX3 TBX3 LHX5 LHX5 ID3 ID3 LIF LIF WNT4 WNT4 MAPK1 MAPK1 MYC MYC ID2 ID2 ZIC3 ZIC3 PCGF3 PCGF3 ISL1 ISL1 TCF3 TCF3 FGFR3 FGFR3 MAP2K2 MAP2K2 ACVR2B ACVR2B HOXB1 HOXB1 STAT3 STAT3 PIK3R2 PIK3R2 PCGF2 PCGF2 JAK3 JAK3 BMPR1A BMPR1A WNT7A WNT7A MYF5 MYF5 LOC111169295 LOC111169295 CTNNB1 CTNNB1 WNT3A WNT3A PCGF1 PCGF1 LOC111169933 LOC111169933 GSK3B GSK3B HRAS HRAS POU5F1 POU5F1 LOC111169240 LOC111169240 SETDB1 SETDB1 FGFR4 FGFR4 BMPR2 BMPR2 FZD5 FZD5 RAF1 RAF1 WNT10A WNT10A FZD2 FZD2 WNT9A WNT9A FGFR2 FGFR2 PCGF6 PCGF6 ACVR1 ACVR1 ACVR1C ACVR1C BMP4 BMP4 DUSP9 DUSP9 KAT6A KAT6A INHBE INHBE INHBB INHBB PIK3CA PIK3CA PCGF5 PCGF5 FZD7 FZD7 INHBC INHBC RIF1 RIF1 HOXD1 HOXD1 JAK2 JAK2 WNT6 WNT6 LOC111173290 LOC111173290 WNT5A WNT5A FGFR1 FGFR1 SMAD9 SMAD9 ACVR2A ACVR2A WNT10B WNT10B PIK3R3 PIK3R3 DVL3 DVL3 AKT1 AKT1 LOC111176725 LOC111176725 KRAS KRAS WNT1 WNT1 SKIL SKIL WNT5B WNT5B AKT3 AKT3 ESRRB ESRRB ONECUT1 ONECUT1 LOC111177522 LOC111177522 BMI1 BMI1 FZD8 FZD8 MAPK14 MAPK14 LOC111176553 LOC111176553 MAPK13 MAPK13 KLF4 KLF4 SMAD3 SMAD3 SMAD4 SMAD4 PIK3CB PIK3CB SMAD2 SMAD2 MAP2K1 MAP2K1 WNT2B WNT2B JAK1 JAK1 FZD1 FZD1 WNT2 WNT2 FZD6 FZD6 JARID2 JARID2 SMARCAD1 SMARCAD1 BMPR1B BMPR1B WNT16 WNT16 PAX6 PAX6 ID4 ID4 ZFHX3 ZFHX3 NRAS NRAS FZD9 FZD9 TCF7 TCF7 NEUROG1 NEUROG1 AKT2 AKT2 MAPK3 MAPK3 DLX5 DLX5 WNT8A WNT8A WNT3 WNT3 HAND1 HAND1 SMAD5 SMAD5 GRB2 GRB2 AXIN2 AXIN2 HOXA1 HOXA1 APC APC ID1 ID1 WNT11 WNT11 INHBA INHBA FZD4 FZD4 AXIN1 AXIN1 FZD3 FZD3 MAPK12 MAPK12 WNT7B WNT7B OTX1 OTX1 IL6ST IL6ST LIFR LIFR MEIS1 MEIS1 DVL2 DVL2 FZD10 FZD10 PIK3R1 PIK3R1 DVL1 DVL1 IGF1R IGF1R MAPK11 MAPK11 SMAD1 SMAD1 IGF1 IGF1 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX3T-box transcription factor TBX3 isoform X1. (745 aa)
LHX5LIM/homeobox protein Lhx5. (402 aa)
ID3DNA-binding protein inhibitor ID-3. (227 aa)
LIFLeukemia inhibitory factor. (202 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
ZIC3Zinc finger protein ZIC 3 isoform X1. (464 aa)
PCGF3Polycomb group RING finger protein 3 isoform X1. (270 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
TCF3Transcription factor E2-alpha isoform X1. (645 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (553 aa)
HOXB1Homeobox protein Hox-B1. (298 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PCGF2Polycomb group RING finger protein 2. (411 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
LOC111169295RE1-silencing transcription factor-like isoform X1. (981 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PCGF1Polycomb group RING finger protein 1. (259 aa)
LOC111169933LOW QUALITY PROTEIN: steroid hormone receptor ERR2-like. (432 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HRASGTPase HRas isoform X1. (189 aa)
POU5F1POU domain protein. (360 aa)
LOC111169240RE1-silencing transcription factor-like isoform X2. (976 aa)
SETDB1Histone-lysine N-methyltransferase SETDB1 isoform X1. (1293 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PCGF6Polycomb group RING finger protein 6 isoform X1. (351 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2027 aa)
INHBEInhibin beta E chain. (351 aa)
INHBBInhibin beta B chain. (407 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PCGF5Polycomb group RING finger protein 5 isoform X1. (256 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
INHBCInhibin beta C chain. (352 aa)
RIF1Telomere-associated protein RIF1 isoform X1. (2467 aa)
HOXD1Homeobox protein Hox-D1. (326 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LOC111173290LOW QUALITY PROTEIN: polycomb group RING finger protein 5-like. (257 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X3. (731 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC111176725Homeobox protein NANOG-like. (245 aa)
KRASGTPase KRas. (188 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SKILSki-like protein isoform X1. (684 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
ESRRBSteroid hormone receptor ERR2 isoform X4. (443 aa)
ONECUT1One cut domain family member. (465 aa)
LOC111177522Left-right determination factor. (367 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC111176553Homeobox protein NANOG-like. (306 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
KLF4Krueppel-like factor 4 isoform X1. (515 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
JARID2Protein Jumonji isoform X1. (1235 aa)
SMARCAD1annotation not available (1028 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (540 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
ZFHX3Zinc finger homeobox protein 3 isoform X1. (3670 aa)
NRASGTPase NRas. (189 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
TCF7Transcription factor 7 isoform X1. (415 aa)
NEUROG1Neurogenin-1. (244 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
DLX5Homeobox protein DLX-5. (289 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AXIN2Axin-2 isoform X1. (843 aa)
HOXA1Homeobox protein Hox-A1. (331 aa)
APCAdenomatous polyposis coli protein isoform X1. (2864 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
INHBAInhibin beta A chain. (425 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
AXIN1Axin-1 isoform X1. (866 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
OTX1Homeobox protein OTX1. (355 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
LIFRLeukemia inhibitory factor receptor isoform X1. (1095 aa)
MEIS1Homeobox protein Meis1 isoform X1. (465 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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