STRINGSTRING
MAPK1 MAPK1 LOC111163731 LOC111163731 IFNAR1 IFNAR1 IFNAR2 IFNAR2 LOC111163732 LOC111163732 MAP3K7 MAP3K7 MYD88 MYD88 CCL5 CCL5 LOC111163733 LOC111163733 LOC111163130 LOC111163130 TIRAP TIRAP MAP2K2 MAP2K2 MAP2K7 MAP2K7 PIK3R2 PIK3R2 TAB2 TAB2 TICAM1 TICAM1 TLR7 TLR7 TLR8 TLR8 MAPK10 MAPK10 MAP2K3 MAP2K3 CTSK CTSK IRF7 IRF7 CD40 CD40 CD80 CD80 IRAK1 IRAK1 IL12B IL12B TLR1 TLR1 MAPK9 MAPK9 CD86 CD86 MAPK8 MAPK8 TOLLIP TOLLIP STAT1 STAT1 CASP8 CASP8 TLR6 TLR6 IKBKG IKBKG LOC111171121 LOC111171121 LOC111171122 LOC111171122 PIK3CA PIK3CA CHUK CHUK TLR3 TLR3 IKBKB IKBKB IFNB1 IFNB1 IRAK4 IRAK4 TLR9 TLR9 PIK3R3 PIK3R3 NFKBIA NFKBIA JUN JUN AKT1 AKT1 TRAF3 TRAF3 TBK1 TBK1 FOS FOS IL12A IL12A TLR5 TLR5 AKT3 AKT3 TLR4 TLR4 MAP3K8 MAP3K8 MAPK14 MAPK14 MAPK13 MAPK13 PIK3CB PIK3CB MAP2K1 MAP2K1 IRF5 IRF5 IRF3 IRF3 SPP1 SPP1 NFKB1 NFKB1 TRAF6 TRAF6 RIPK1 RIPK1 AKT2 AKT2 MAPK3 MAPK3 MAP2K6 MAP2K6 RAC1 RAC1 FADD FADD CD14 CD14 RELA RELA TICAM2 TICAM2 LBP LBP MAP2K4 MAP2K4 LY96 LY96 TAB1 TAB1 IKBKE IKBKE MAPK12 MAPK12 CXCL10 CXCL10 PIK3R1 PIK3R1 MAPK11 MAPK11 CXCL8 CXCL8 CXCL11 CXCL11 PIK3CD PIK3CD CXCL9 CXCL9 TLR2 TLR2 TNF TNF IL1B IL1B IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
LOC111163731C-C motif chemokine. (93 aa)
IFNAR1Interferon alpha/beta receptor 1 isoform X1. (561 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (594 aa)
LOC111163732C-C motif chemokine. (92 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
CCL5C-C motif chemokine. (91 aa)
LOC111163733C-C motif chemokine. (90 aa)
LOC111163130Interferon alpha-1-like. (226 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (226 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (707 aa)
TLR7Toll-like receptor 7 isoform X1. (1086 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1035 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
CTSKCathepsin K isoform X1; Belongs to the peptidase C1 family. (358 aa)
IRF7Interferon regulatory factor 7 isoform X1. (473 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (796 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TOLLIPToll-interacting protein isoform X1. (273 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (797 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
LOC111171121Interferon alpha-1-like. (133 aa)
LOC111171122Interferon alpha-1-like isoform X1. (195 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
IFNB1Interferon beta. (185 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
FOSProto-oncogene c-Fos. (380 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IRF5Interferon regulatory factor 5 isoform X1. (517 aa)
IRF3Interferon regulatory factor 3 isoform X1. (464 aa)
SPP1Osteopontin. (362 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
RELATranscription factor p65 isoform X1. (562 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
LBPLipopolysaccharide-binding protein isoform X1. (537 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
LY96Lymphocyte antigen 96. (160 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (807 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
CXCL10C-X-C motif chemokine. (103 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
CXCL11C-X-C motif chemokine 11. (100 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
CXCL9C-X-C motif chemokine. (160 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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