STRINGSTRING
CNTFR CNTFR LIF LIF IFNLR1 IFNLR1 SOCS1 SOCS1 SOCS2 SOCS2 IFNAR1 IFNAR1 IFNAR2 IFNAR2 IFNGR2 IFNGR2 IL22RA1 IL22RA1 OSM OSM IRF9 IRF9 MYC MYC PTPN2 PTPN2 LOC111163129 LOC111163129 FHL1 FHL1 IL10RB IL10RB IFNE IFNE LOC111163130 LOC111163130 IL11RA IL11RA LOC111165942 LOC111165942 IL13RA2 IL13RA2 TYK2 TYK2 IFNGR1 IFNGR1 IL20RA IL20RA CSF3 CSF3 STAT5A STAT5A LOC111166483 LOC111166483 STAT3 STAT3 PIK3R2 PIK3R2 IL27RA IL27RA IL12RB1 IL12RB1 IL7 IL7 SOCS7 SOCS7 JAK3 JAK3 CSF2RA CSF2RA PIAS4 PIAS4 PIAS2 PIAS2 IL22RA2 IL22RA2 PDGFA PDGFA IL10RA IL10RA PDGFRA PDGFRA IL13RA1 IL13RA1 IL6R IL6R GFAP GFAP HRAS HRAS IL2RG IL2RG IL12B IL12B IL3RA IL3RA CRLF2 CRLF2 RAF1 RAF1 STAT1 STAT1 LOC111171714 LOC111171714 MCL1 MCL1 LOC111171121 LOC111171121 STAM2 STAM2 SOCS4 SOCS4 STAT2 STAT2 LOC111171122 LOC111171122 SOS2 SOS2 PIK3CA PIK3CA STAT6 STAT6 STAT4 STAT4 IL22 IL22 IFNB1 IFNB1 JAK2 JAK2 THPO THPO SOCS5 SOCS5 IL5RA IL5RA IL17D IL17D SOS1 SOS1 PIK3R3 PIK3R3 CISH CISH AKT1 AKT1 MPL MPL IFNG IFNG CCND2 CCND2 IL12A IL12A AKT3 AKT3 PTPN6 PTPN6 CSF3R CSF3R STAM STAM CCND3 CCND3 LEPR LEPR CDKN1A CDKN1A PIM1 PIM1 IL20RB IL20RB PIK3CB PIK3CB PIAS1 PIAS1 IL12RB2 IL12RB2 IL2RA IL2RA IL23R IL23R JAK1 JAK1 LOC111180531 LOC111180531 IL11 IL11 BCL2 BCL2 PIAS3 PIAS3 LOC111180533 LOC111180533 SOCS6 SOCS6 IL13 IL13 AKT2 AKT2 IL4R IL4R IL21R IL21R IL9 IL9 LOC111182131 LOC111182131 PRL PRL CSF2 CSF2 SOCS3 SOCS3 GRB2 GRB2 PDGFRB PDGFRB CNTF CNTF LOC111182135 LOC111182135 EPO EPO IL5 IL5 CCND1 CCND1 IL4 IL4 LOC111182618 LOC111182618 IL10 IL10 IL24 IL24 BCL2L1 BCL2L1 CREBBP CREBBP CSF2RB CSF2RB PDGFB PDGFB EGFR EGFR IL19 IL19 IL9R IL9R IL2RB IL2RB EP300 EP300 OSMR OSMR IL6ST IL6ST LIFR LIFR IL7R IL7R PIK3R1 PIK3R1 IL21 IL21 MTOR MTOR PRLR PRLR PTPN11 PTPN11 GHR GHR LOC111187198 LOC111187198 PIK3CD PIK3CD IL15 IL15 Ob Ob IL6 IL6 IL2 IL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNTFRCiliary neurotrophic factor receptor subunit alpha isoform X1. (374 aa)
LIFLeukemia inhibitory factor. (202 aa)
IFNLR1Interferon lambda receptor 1 isoform X1. (535 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
IFNAR1Interferon alpha/beta receptor 1 isoform X1. (561 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (594 aa)
IFNGR2Interferon gamma receptor 2. (364 aa)
IL22RA1Interleukin-22 receptor subunit alpha-1. (581 aa)
OSMoncostatin-M. (246 aa)
IRF9LOW QUALITY PROTEIN: interferon regulatory factor 9. (479 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
LOC111163129Interferon omega-1-like. (250 aa)
FHL1Four and a half LIM domains protein 1 isoform X1. (339 aa)
IL10RBInterleukin-10 receptor subunit beta isoform X1. (361 aa)
IFNEInterferon epsilon. (193 aa)
LOC111163130Interferon alpha-1-like. (226 aa)
IL11RAInterleukin-11 receptor subunit alpha isoform X3. (426 aa)
LOC111165942Erythropoietin receptor; Receptor for erythropoietin. (509 aa)
IL13RA2Interleukin-13 receptor subunit alpha-2. (387 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
IL20RAInterleukin-20 receptor subunit alpha isoform X2. (559 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
IL12RB1Interleukin-12 receptor subunit beta-1 isoform X1. (726 aa)
IL7Interleukin-7 isoform X1. (226 aa)
SOCS7Suppressor of cytokine signaling 7 isoform X1. (641 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
CSF2RAGranulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1. (430 aa)
PIAS4E3 SUMO-protein ligase PIAS4 isoform X1. (520 aa)
PIAS2E3 SUMO-protein ligase PIAS2 isoform X1. (622 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2. (318 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
IL10RAInterleukin-10 receptor subunit alpha isoform X1. (579 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
IL13RA1Interleukin-13 receptor subunit alpha-1. (425 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (465 aa)
GFAPGlial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. (470 aa)
HRASGTPase HRas isoform X1. (189 aa)
IL2RGCytokine receptor common subunit gamma isoform X1. (381 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
IL3RAInterleukin-3 receptor subunit alpha isoform X1. (473 aa)
CRLF2Cytokine receptor-like factor 2. (367 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
LOC111171714Aldehyde oxidase 1 isoform X1. (1338 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1. (351 aa)
LOC111171121Interferon alpha-1-like. (133 aa)
STAM2Signal transducing adapter molecule 2 isoform X1. (604 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
STAT2Signal transducer and activator of transcription. (911 aa)
LOC111171122Interferon alpha-1-like isoform X1. (195 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
IL22Interleukin-22. (189 aa)
IFNB1Interferon beta. (185 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
THPOThrombopoietin isoform X1. (324 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
IL5RAInterleukin-5 receptor subunit alpha isoform X1. (417 aa)
IL17Dinterleukin-17D. (309 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
CISHCytokine-inducible SH2-containing protein isoform X1. (254 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MPLThrombopoietin receptor. (645 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CSF3RGranulocyte colony-stimulating factor receptor isoform X1. (846 aa)
STAMSignal transducing adapter molecule 1. (526 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
LEPRLeptin receptor isoform X1. (917 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (347 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (342 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (651 aa)
IL12RB2Interleukin-12 receptor subunit beta-2 isoform X1. (861 aa)
IL2RAInterleukin-2 receptor subunit alpha. (275 aa)
IL23RInterleukin-23 receptor. (630 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
LOC111180531Interferon lambda-3-like. (113 aa)
IL11Interleukin-11. (199 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
PIAS3E3 SUMO-protein ligase PIAS3 isoform X1. (628 aa)
LOC111180533Interferon lambda-3-like. (110 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
IL13Interleukin-13. (131 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X1. (831 aa)
IL21RInterleukin-21 receptor isoform X2. (560 aa)
IL9Interleukin-9. (141 aa)
LOC111182131Cardiotrophin-1-like isoform X1. (264 aa)
PRLProlactin isoform X1. (230 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
CNTFCiliary neurotrophic factor. (200 aa)
LOC111182135Cardiotrophin-2. (202 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
LOC111182618Somatotropin isoform X1. (262 aa)
IL10Interleukin-10. (178 aa)
IL24Interleukin-24 isoform X1. (209 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
CSF2RBCytokine receptor common subunit beta. (902 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
IL19Interleukin-19. (177 aa)
IL9RInterleukin-9 receptor. (469 aa)
IL2RBInterleukin-2 receptor subunit beta isoform X1. (595 aa)
EP300Histone acetyltransferase p300. (2420 aa)
OSMRoncostatin-M-specific receptor subunit beta isoform X1. (977 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
LIFRLeukemia inhibitory factor receptor isoform X1. (1095 aa)
IL7RInterleukin-7 receptor subunit alpha isoform X1. (459 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (673 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
GHRGrowth hormone receptor isoform X1. (676 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
ObLeptin isoform X1. (167 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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