STRINGSTRING
GP1BB GP1BB KITLG KITLG IL11RA IL11RA LOC111164621 LOC111164621 LOC111165942 LOC111165942 CSF3 CSF3 LOC111164620 LOC111164620 CD3D CD3D CD3G CD3G CD3E CD3E IL7 IL7 CD8A CD8A CD8B CD8B ITGA3 ITGA3 CSF2RA CSF2RA LOC111167107 LOC111167107 KIT KIT IL6R IL6R ITGA2B ITGA2B LOC111168646 LOC111168646 GP9 GP9 IL3RA IL3RA ITGA4 ITGA4 ANPEP ANPEP DNTT DNTT TFRC TFRC CD38 CD38 THPO THPO IL5RA IL5RA GP5 GP5 FLT3 FLT3 ITGA6 ITGA6 CD9 CD9 CSF3R CSF3R LOC111178664 LOC111178664 LOC111178928 LOC111178928 LOC111178931 LOC111178931 LOC111178668 LOC111178668 LOC111178925 LOC111178925 LOC111178929 LOC111178929 MME MME FLT3LG FLT3LG CD37 CD37 IL2RA IL2RA LOC111178666 LOC111178666 CD22 CD22 LOC111178927 LOC111178927 CD44 CD44 CD2 CD2 IL11 IL11 CD59 CD59 CD19 CD19 CSF1 CSF1 ITGB3 ITGB3 IL4R IL4R ITGAM ITGAM CSF2 CSF2 EPO EPO IL5 IL5 IL4 IL4 LOC111183908 LOC111183908 CD14 CD14 CD7 CD7 CR2 CR2 CSF1R CSF1R CR1 CR1 CD34 CD34 CD5 CD5 CD55 CD55 IL9R IL9R IL1A IL1A IL7R IL7R GYPA GYPA ITGA2 ITGA2 ITGA1 ITGA1 IL1R1 IL1R1 IL1R2 IL1R2 TNF TNF IL1B IL1B CD4 CD4 IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GP1BBPlatelet glycoprotein Ib beta chain. (205 aa)
KITLGKit ligand isoform X1. (295 aa)
IL11RAInterleukin-11 receptor subunit alpha isoform X3. (426 aa)
LOC111164621Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
LOC111165942Erythropoietin receptor; Receptor for erythropoietin. (509 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
LOC111164620Platelet glycoprotein 4-like; Belongs to the CD36 family. (472 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (197 aa)
IL7Interleukin-7 isoform X1. (226 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain isoform X1. (239 aa)
CD8BT-cell surface glycoprotein CD8 beta chain. (210 aa)
ITGA3Integrin alpha-3 isoform X1; Belongs to the integrin alpha chain family. (1068 aa)
CSF2RAGranulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1. (430 aa)
LOC111167107T-cell surface glycoprotein CD1b-2-like. (333 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (465 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (1034 aa)
LOC111168646CD59 glycoprotein-like. (123 aa)
GP9Platelet glycoprotein IX. (177 aa)
IL3RAInterleukin-3 receptor subunit alpha isoform X1. (473 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
ANPEPAminopeptidase. (969 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (510 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
CD38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1. (307 aa)
THPOThrombopoietin isoform X1. (324 aa)
IL5RAInterleukin-5 receptor subunit alpha isoform X1. (417 aa)
GP5Platelet glycoprotein V. (569 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1091 aa)
CD9CD9 antigen isoform X1; Belongs to the tetraspanin (TM4SF) family. (270 aa)
CSF3RGranulocyte colony-stimulating factor receptor isoform X1. (846 aa)
LOC111178664HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
LOC111178928DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC111178931HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
LOC111178668HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
LOC111178925boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X2. (276 aa)
LOC111178929HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1. (231 aa)
MMENeprilysin. (750 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (328 aa)
CD37Tetraspanin. (370 aa)
IL2RAInterleukin-2 receptor subunit alpha. (275 aa)
LOC111178666HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
CD22B-cell receptor CD22. (843 aa)
LOC111178927HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family. (255 aa)
CD44CD44 antigen isoform X1. (742 aa)
CD2T-cell surface antigen CD2 isoform X1. (340 aa)
IL11Interleukin-11. (199 aa)
CD59CD59 glycoprotein. (123 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (570 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X1. (831 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (872 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
LOC111183908B-lymphocyte antigen CD20-like. (303 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
CD7T-cell antigen CD7. (208 aa)
CR2Complement receptor type 2 isoform X1. (1471 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
CR1Complement receptor type 1 isoform X1. (1062 aa)
CD34Hematopoietic progenitor cell antigen CD34 isoform X1. (384 aa)
CD5T-cell surface glycoprotein CD5 isoform X1. (500 aa)
CD55Complement decay-accelerating factor isoform X1. (590 aa)
IL9RInterleukin-9 receptor. (469 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
IL7RInterleukin-7 receptor subunit alpha isoform X1. (459 aa)
GYPAglycophorin-A isoform X1. (141 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
ITGA1Integrin alpha-1; Belongs to the integrin alpha chain family. (1178 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (686 aa)
IL1R2Interleukin-1 receptor type 2. (421 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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