STRINGSTRING
MAPK1 MAPK1 IFNAR1 IFNAR1 IFNAR2 IFNAR2 IFNGR2 IFNGR2 FYN FYN LOC111163130 LOC111163130 VAV1 VAV1 SH3BP2 SH3BP2 MAP2K2 MAP2K2 ICAM1 ICAM1 IFNGR1 IFNGR1 LOC111164169 LOC111164169 LOC111164234 LOC111164234 PIK3R2 PIK3R2 ARAF ARAF FCER1G FCER1G SHC1 SHC1 CD244 CD244 SHC3 SHC3 SH2D1A SH2D1A LOC111166880 LOC111166880 CD48 CD48 NFATC1 NFATC1 CD247 CD247 FASLG FASLG SYK SYK HRAS HRAS SH2D1B SH2D1B NCR3 NCR3 RAF1 RAF1 PPP3CC PPP3CC LOC111170413 LOC111170413 LOC111170649 LOC111170649 FAS FAS LOC111171121 LOC111171121 SHC2 SHC2 LOC111171122 LOC111171122 SOS2 SOS2 PIK3CA PIK3CA CASP3 CASP3 TNFSF10 TNFSF10 IFNB1 IFNB1 SOS1 SOS1 PIK3R3 PIK3R3 IFNG IFNG LOC111176758 LOC111176758 KRAS KRAS VAV2 VAV2 PTPN6 PTPN6 KLRD1 KLRD1 LCK LCK BRAF BRAF BID BID PLCG2 PLCG2 PIK3CB PIK3CB MAP2K1 MAP2K1 VAV3 VAV3 PPP3CA PPP3CA NRAS NRAS RAC3 RAC3 MAPK3 MAPK3 PRKCB PRKCB ICAM2 ICAM2 NCR1 NCR1 CSF2 CSF2 TYROBP TYROBP PRKCA PRKCA GRB2 GRB2 SHC4 SHC4 ITGAL ITGAL RAC1 RAC1 PLCG1 PLCG1 PRF1 PRF1 PPP3CB PPP3CB LAT LAT PAK1 PAK1 RAC2 RAC2 PTK2B PTK2B LOC111185435 LOC111185435 LOC111185436 LOC111185436 LCP2 LCP2 LOC111187417 LOC111187417 PIK3R1 PIK3R1 ITGB2 ITGB2 PPP3R1 PPP3R1 NFATC2 NFATC2 PTPN11 PTPN11 PPP3R2 PPP3R2 LOC111187198 LOC111187198 PIK3CD PIK3CD TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
IFNAR1Interferon alpha/beta receptor 1 isoform X1. (561 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (594 aa)
IFNGR2Interferon gamma receptor 2. (364 aa)
FYNTyrosine-protein kinase. (537 aa)
LOC111163130Interferon alpha-1-like. (226 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
SH3BP2SH3 domain-binding protein 2 isoform X1. (617 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
LOC111164169LOW QUALITY PROTEIN: mast cell protease 3-like; Belongs to the peptidase S1 family. (261 aa)
LOC111164234Granzyme B-like isoform X1; Belongs to the peptidase S1 family. (248 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
CD244Natural killer cell receptor 2B4. (369 aa)
SHC3SHC-transforming protein 3. (588 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
LOC111166880LOW QUALITY PROTEIN: NKG2D ligand 4-like. (234 aa)
CD48CD48 antigen isoform X1. (237 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa)
CD247T-cell surface glycoprotein CD3 zeta chain isoform X1. (185 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
SYKTyrosine-protein kinase. (626 aa)
HRASGTPase HRas isoform X1. (189 aa)
SH2D1BSH2 domain-containing protein 1B isoform X1. (138 aa)
NCR3Natural cytotoxicity triggering receptor 3. (180 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
LOC111170413Low affinity immunoglobulin gamma Fc region receptor III-like isoform X1. (278 aa)
LOC111170649MHC class I polypeptide-related sequence B-like isoform X1. (256 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
LOC111171121Interferon alpha-1-like. (133 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
LOC111171122Interferon alpha-1-like isoform X1. (195 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (288 aa)
IFNB1Interferon beta. (185 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC111176758NKG2-A/NKG2-B type II integral membrane protein-like isoform X1. (256 aa)
KRASGTPase KRas. (188 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
KLRD1Natural killer cells antigen CD94 isoform X1. (240 aa)
LCKTyrosine-protein kinase. (509 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NRASGTPase NRas. (189 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
ICAM2Intercellular adhesion molecule 2 isoform X1. (292 aa)
NCR1Natural cytotoxicity triggering receptor 1 isoform X1. (330 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (126 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1166 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PRF1Perforin-1. (555 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
LATLinker for activation of T-cells family member 1 isoform X1. (270 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
LOC111185435Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa)
LOC111185436Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa)
LCP2Lymphocyte cytosolic protein 2 isoform X1. (534 aa)
LOC111187417Tyrosine-protein kinase. (612 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ITGB2Integrin beta. (769 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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