STRINGSTRING
CDC42 CDC42 MAPK1 MAPK1 MAP3K7 MAP3K7 CD40LG CD40LG FYN FYN PAK5 PAK5 VAV1 VAV1 MAP2K2 MAP2K2 MAP2K7 MAP2K7 PIK3R2 PIK3R2 CD3D CD3D CD3G CD3G CD3E CD3E CD8A CD8A CD8B CD8B PAK3 PAK3 PTPRC PTPRC MAPK10 MAPK10 GSK3B GSK3B NFATC1 NFATC1 CD247 CD247 MAP3K14 MAP3K14 HRAS HRAS TEC TEC MAPK9 MAPK9 CARD11 CARD11 MAPK8 MAPK8 ICOS ICOS RAF1 RAF1 PPP3CC PPP3CC CD28 CD28 DLG1 DLG1 PDCD1 PDCD1 IKBKG IKBKG PAK2 PAK2 CTLA4 CTLA4 CDK4 CDK4 SOS2 SOS2 PIK3CA PIK3CA CHUK CHUK IKBKB IKBKB SOS1 SOS1 PIK3R3 PIK3R3 NFKBIA NFKBIA JUN JUN RHOA RHOA AKT1 AKT1 IFNG IFNG KRAS KRAS VAV2 VAV2 FOS FOS AKT3 AKT3 PTPN6 PTPN6 MAP3K8 MAP3K8 LCK LCK MAPK14 MAPK14 PRKCQ PRKCQ NCK1 NCK1 MAPK13 MAPK13 NFKBIE NFKBIE PIK3CB PIK3CB MAP2K1 MAP2K1 NFKBIB NFKBIB BCL10 BCL10 VAV3 VAV3 NFKB1 NFKB1 PPP3CA PPP3CA NFATC3 NFATC3 MALT1 MALT1 NRAS NRAS RASGRP1 RASGRP1 AKT2 AKT2 MAPK3 MAPK3 PAK4 PAK4 ITK ITK CSF2 CSF2 GRB2 GRB2 IL5 IL5 PLCG1 PLCG1 PPP3CB PPP3CB LAT LAT IL4 IL4 RELA RELA IL10 IL10 PAK1 PAK1 CBLB CBLB LOC111186270 LOC111186270 PDPK1 PDPK1 MAPK12 MAPK12 LCP2 LCP2 LOC111187417 LOC111187417 PIK3R1 PIK3R1 MAPK11 MAPK11 NCK2 NCK2 PPP3R1 PPP3R1 NFATC2 NFATC2 PPP3R2 PPP3R2 PIK3CD PIK3CD TNF TNF CD4 CD4 IL2 IL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
FYNTyrosine-protein kinase. (537 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (197 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain isoform X1. (239 aa)
CD8BT-cell surface glycoprotein CD8 beta chain. (210 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa)
CD247T-cell surface glycoprotein CD3 zeta chain isoform X1. (185 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14 isoform X1. (961 aa)
HRASGTPase HRas isoform X1. (189 aa)
TECTyrosine-protein kinase. (658 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CARD11Caspase recruitment domain-containing protein 11 isoform X1. (1154 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ICOSInducible T-cell costimulator isoform X1. (227 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
PDCD1Programmed cell death protein 1 isoform X1. (288 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
KRASGTPase KRas. (188 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
FOSProto-oncogene c-Fos. (380 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
LCKTyrosine-protein kinase. (509 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PRKCQProtein kinase C. (665 aa)
NCK1Cytoplasmic protein. (377 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
NFKBIENF-kappa-B inhibitor epsilon isoform X1. (365 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
NRASGTPase NRas. (189 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (870 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PAK4Non-specific serine/threonine protein kinase. (594 aa)
ITKTyrosine-protein kinase. (620 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
LATLinker for activation of T-cells family member 1 isoform X1. (270 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
RELATranscription factor p65 isoform X1. (562 aa)
IL10Interleukin-10. (178 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
LOC111186270GRB2-related adapter protein 2 isoform X1. (337 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
LCP2Lymphocyte cytosolic protein 2 isoform X1. (534 aa)
LOC111187417Tyrosine-protein kinase. (612 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
NCK2Cytoplasmic protein. (376 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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