STRINGSTRING
MAPK1 MAPK1 FYN FYN VAV1 VAV1 MAP2K2 MAP2K2 MAP2K7 MAP2K7 PIK3R2 PIK3R2 FCER1G FCER1G LYN LYN MAPK10 MAPK10 MAP2K3 MAP2K3 FCER1A FCER1A SYK SYK HRAS HRAS MAPK9 MAPK9 MAPK8 MAPK8 RAF1 RAF1 ALOX5 ALOX5 INPP5D INPP5D SOS2 SOS2 PIK3CA PIK3CA SOS1 SOS1 PIK3R3 PIK3R3 AKT1 AKT1 KRAS KRAS VAV2 VAV2 AKT3 AKT3 ALOX5AP ALOX5AP MAPK14 MAPK14 BTK BTK MAPK13 MAPK13 PLCG2 PLCG2 PIK3CB PIK3CB MAP2K1 MAP2K1 VAV3 VAV3 PLA2G4F PLA2G4F NRAS NRAS IL13 IL13 PLA2G4E PLA2G4E RAC3 RAC3 AKT2 AKT2 MAPK3 MAPK3 CSF2 CSF2 MAP2K6 MAP2K6 PRKCA PRKCA GRB2 GRB2 RAC1 RAC1 IL5 IL5 PLCG1 PLCG1 LAT LAT IL4 IL4 MS4A2 MS4A2 MAP2K4 MAP2K4 RAC2 RAC2 PLA2G4A PLA2G4A GAB2 GAB2 PDPK1 PDPK1 MAPK12 MAPK12 LCP2 LCP2 PIK3R1 PIK3R1 MAPK11 MAPK11 PIK3CD PIK3CD TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
FYNTyrosine-protein kinase. (537 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
LYNTyrosine-protein kinase. (518 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
FCER1AHigh affinity immunoglobulin epsilon receptor subunit alpha isoform X1. (258 aa)
SYKTyrosine-protein kinase. (626 aa)
HRASGTPase HRas isoform X1. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KRASGTPase KRas. (188 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
ALOX5APArachidonate 5-lipoxygenase-activating protein. (161 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BTKTyrosine-protein kinase. (687 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
PLA2G4FPhospholipase A2. (849 aa)
NRASGTPase NRas. (189 aa)
IL13Interleukin-13. (131 aa)
PLA2G4EPhospholipase A2. (868 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LATLinker for activation of T-cells family member 1 isoform X1. (270 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta. (243 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
PLA2G4APhospholipase A2. (749 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
LCP2Lymphocyte cytosolic protein 2 isoform X1. (534 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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