STRINGSTRING
LOC111162707 LOC111162707 CRKL CRKL CDC42 CDC42 ASAP3 ASAP3 MAPK1 MAPK1 RPS6KB1 RPS6KB1 ASAP2 ASAP2 WASF1 WASF1 ASAP1 ASAP1 MARCKS MARCKS WASF2 WASF2 VAV1 VAV1 DNM2 DNM2 LOC111166071 LOC111166071 PIK3R2 PIK3R2 LYN LYN PIP5K1C PIP5K1C PTPRC PTPRC WAS WAS PIP5K1A PIP5K1A ARPC4 ARPC4 SYK SYK RAF1 RAF1 DOCK1 DOCK1 LOC111170413 LOC111170413 INPPL1 INPPL1 PLPP2 PLPP2 ARPC2 ARPC2 ARF6 ARF6 INPP5D INPP5D PIK3CA PIK3CA PLD1 PLD1 PIP5K1B PIP5K1B CFL2 CFL2 PRKCE PRKCE PIK3R3 PIK3R3 PRKCD PRKCD AKT1 AKT1 PLPP3 PLPP3 VAV2 VAV2 MARCKSL1 MARCKSL1 GSN GSN AKT3 AKT3 MYO10 MYO10 PLCG2 PLCG2 ARPC5L ARPC5L PIK3CB PIK3CB MAP2K1 MAP2K1 VAV3 VAV3 VASP VASP SCIN SCIN PLA2G4F PLA2G4F LIMK1 LIMK1 NCF1 NCF1 PLA2G4E PLA2G4E AKT2 AKT2 MAPK3 MAPK3 ARPC1A ARPC1A SPHK2 SPHK2 PRKCB PRKCB PRKCA PRKCA SPHK1 SPHK1 RPS6KB2 RPS6KB2 CFL1 CFL1 RAC1 RAC1 ARPC1B ARPC1B PLCG1 PLCG1 LAT LAT LOC111184310 LOC111184310 BIN1 BIN1 HCK HCK PAK1 PAK1 CRK CRK PLD2 PLD2 RAC2 RAC2 LOC111184478 LOC111184478 ARPC5 ARPC5 PLA2G4A PLA2G4A GAB2 GAB2 ARPC3 ARPC3 PIK3R1 PIK3R1 PLA2G6 PLA2G6 PLPP1 PLPP1 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111162707LIM domain kinase 2 isoform X1. (837 aa)
CRKLCrk-like protein. (303 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
ASAP3arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1. (906 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ASAP2arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1. (1011 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (559 aa)
ASAP1arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1. (1119 aa)
MARCKSMyristoylated alanine-rich C-kinase substrate. (334 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
LOC111166071Phospholipid phosphatase 3-like. (264 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LYNTyrosine-protein kinase. (518 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
SYKTyrosine-protein kinase. (626 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
DOCK1Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1886 aa)
LOC111170413Low affinity immunoglobulin gamma Fc region receptor III-like isoform X1. (278 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1. (1264 aa)
PLPP2LOW QUALITY PROTEIN: phospholipid phosphatase 2. (345 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLD1Phospholipase. (1151 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
PRKCEProtein kinase C. (746 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
MARCKSL1MARCKS-related protein. (198 aa)
GSNGelsolin isoform X1. (770 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
MYO10Unconventional myosin-X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2055 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (384 aa)
SCINAdseverin isoform X1. (715 aa)
PLA2G4FPhospholipase A2. (849 aa)
LIMK1LIM domain kinase 1 isoform X1. (647 aa)
NCF1Neutrophil cytosol factor 1 isoform X2. (405 aa)
PLA2G4EPhospholipase A2. (868 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
PRKCBProtein kinase C. (689 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
SPHK1Sphingosine kinase 1 isoform X2. (484 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B isoform X1. (425 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LATLinker for activation of T-cells family member 1 isoform X1. (270 aa)
LOC111184310Tyrosine-protein kinase. (369 aa)
BIN1Myc box-dependent-interacting protein 1 isoform X1. (594 aa)
HCKTyrosine-protein kinase. (506 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PLD2Phospholipase. (933 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
LOC111184478Amphiphysin isoform X1. (685 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
PLA2G4APhospholipase A2. (749 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X2. (835 aa)
PLPP1Phospholipid phosphatase 1 isoform X1. (286 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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