STRINGSTRING
LIF LIF MAPK1 MAPK1 MAP3K7 MAP3K7 CCL5 CCL5 NOD2 NOD2 CX3CL1 CX3CL1 MAP2K7 MAP2K7 ICAM1 ICAM1 MMP14 MMP14 TNFAIP3 TNFAIP3 JUNB JUNB PIK3R2 PIK3R2 TAB2 TAB2 CREB3L4 CREB3L4 JAG1 JAG1 LOC111166693 LOC111166693 BIRC3 BIRC3 MAPK10 MAPK10 MAP3K5 MAP3K5 CREB3L3 CREB3L3 TAB3 TAB3 SELE SELE LOC111167570 LOC111167570 MAP2K3 MAP2K3 LOC111168369 LOC111168369 MAP3K14 MAP3K14 VEGFD VEGFD MAPK9 MAPK9 ATF6B ATF6B CFLAR CFLAR CASP10 CASP10 LTA LTA MAPK8 MAPK8 MMP9 MMP9 CCL20 CCL20 CASP8 CASP8 FAS FAS IKBKG IKBKG CREB1 CREB1 PIK3CA PIK3CA VEGFC VEGFC CHUK CHUK CASP3 CASP3 IKBKB IKBKB IFNB1 IFNB1 CASP7 CASP7 ATF2 ATF2 PIK3R3 PIK3R3 NFKBIA NFKBIA JUN JUN AKT1 AKT1 TRAF3 TRAF3 RPS6KA5 RPS6KA5 DNM1L DNM1L FOS FOS AKT3 AKT3 TRAF2 TRAF2 MAP3K8 MAP3K8 MAPK14 MAPK14 TRAF1 TRAF1 MAPK13 MAPK13 TNFRSF1A TNFRSF1A CREB3L2 CREB3L2 DAB2IP DAB2IP PIK3CB PIK3CB MAP2K1 MAP2K1 VCAM1 VCAM1 NFKB1 NFKB1 BCL3 BCL3 TRADD TRADD MLKL MLKL CREB5 CREB5 RIPK1 RIPK1 CSF1 CSF1 IRF1 IRF1 AKT2 AKT2 MAPK3 MAPK3 CSF2 CSF2 EDN1 EDN1 MAP2K6 MAP2K6 SOCS3 SOCS3 FADD FADD RPS6KA4 RPS6KA4 RELA RELA CREB3L1 CREB3L1 ITCH ITCH MAP2K4 MAP2K4 ATF4 ATF4 LOC111185731 LOC111185731 PTGS2 PTGS2 TRAF5 TRAF5 TAB1 TAB1 MAPK12 MAPK12 IL18R1 IL18R1 CEBPB CEBPB CXCL10 CXCL10 LOC111187662 LOC111187662 PGAM5 PGAM5 TNFRSF1B TNFRSF1B PIK3R1 PIK3R1 MAPK11 MAPK11 LOC111187576 LOC111187576 PIK3CD PIK3CD LOC111187648 LOC111187648 LOC111187591 LOC111187591 IL15 IL15 CREB3 CREB3 TNF TNF IL1B IL1B IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIFLeukemia inhibitory factor. (202 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CCL5C-C motif chemokine. (91 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
CX3CL1Fractalkine. (469 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
JUNBTranscription factor jun-B. (347 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
LOC111166693T-cell-specific guanine nucleotide triphosphate-binding protein 1-like. (414 aa)
BIRC3Baculoviral IAP repeat-containing protein 3 isoform X1. (604 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
SELEE-selectin. (531 aa)
LOC111167570Stromelysin-1-like. (479 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC111168369Baculoviral IAP repeat-containing protein 2. (620 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14 isoform X1. (961 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (547 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (518 aa)
LTALymphotoxin-alpha; Belongs to the tumor necrosis factor family. (205 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
CCL20C-C motif chemokine. (97 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
IFNB1Interferon beta. (185 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (763 aa)
FOSProto-oncogene c-Fos. (380 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TRAF1TNF receptor-associated factor. (415 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
VCAM1Vascular cell adhesion protein 1. (739 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
MLKLLOW QUALITY PROTEIN: mixed lineage kinase domain-like protein. (405 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
IRF1Interferon regulatory factor. (322 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
EDN1Endothelin-1. (202 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
RELATranscription factor p65 isoform X1. (562 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
LOC111185731C-C motif chemokine. (99 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
IL18R1Interleukin-18 receptor 1 isoform X1. (539 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
CXCL10C-X-C motif chemokine. (103 aa)
LOC111187662C-X-C motif chemokine. (104 aa)
PGAM5Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1. (289 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (454 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
LOC111187576C-X-C motif chemokine. (104 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
LOC111187648C-X-C motif chemokine 6-like. (113 aa)
LOC111187591C-X-C motif chemokine. (104 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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