STRINGSTRING
MYL12B MYL12B CLDN5 CLDN5 CDC42 CDC42 LOC111162912 LOC111162912 ROCK2 ROCK2 GNAI1 GNAI1 VAV1 VAV1 CLDN14 CLDN14 ICAM1 ICAM1 ARHGAP5 ARHGAP5 CTNNA2 CTNNA2 PIK3R2 PIK3R2 MMP2 MMP2 EZR EZR ESAM ESAM JAM3 JAM3 AFDN AFDN CD99 CD99 CLDN25 CLDN25 XG XG CTNNB1 CTNNB1 CD99L2 CD99L2 F11R F11R THY1 THY1 MSN MSN ACTB ACTB CLDN2 CLDN2 TXK TXK MMP9 MMP9 ITGA4 ITGA4 CXCL12 CXCL12 RHOH RHOH LOC111170450 LOC111170450 CLDN1 CLDN1 CLDN23 CLDN23 RAPGEF4 RAPGEF4 ACTN1 ACTN1 PIK3CA PIK3CA RAPGEF3 RAPGEF3 CLDN11 CLDN11 CXCR4 CXCR4 GNAI2 GNAI2 JAM2 JAM2 CLDN8 CLDN8 LOC111173597 LOC111173597 CLDN19 CLDN19 PIK3R3 PIK3R3 RHOA RHOA RAP1B RAP1B CLDN10 CLDN10 CLDN17 CLDN17 VAV2 VAV2 CLDN16 CLDN16 MAPK14 MAPK14 LOC111178986 LOC111178986 MAPK13 MAPK13 LOC111179403 LOC111179403 PLCG2 PLCG2 BCAR1 BCAR1 ITGB1 ITGB1 PIK3CB PIK3CB VCAM1 VCAM1 CDH5 CDH5 RAP1A RAP1A VAV3 VAV3 VASP VASP ACTN4 ACTN4 ARHGAP35 ARHGAP35 CLDN15 CLDN15 NCF1 NCF1 ROCK1 ROCK1 GNAI3 GNAI3 MYLPF MYLPF ITGAM ITGAM MYL10 MYL10 CLDN3 CLDN3 CTNNA1 CTNNA1 PRKCB PRKCB ITK ITK PRKCA PRKCA ACTG1 ACTG1 CTNNA3 CTNNA3 ITGAL ITGAL RAC1 RAC1 CLDN4 CLDN4 PLCG1 PLCG1 PECAM1 PECAM1 CTNND1 CTNND1 SIPA1 SIPA1 NCF2 NCF2 MYL9 MYL9 RASSF5 RASSF5 CLDN6 CLDN6 RAC2 RAC2 MYL7 MYL7 CLDN7 CLDN7 OCLN OCLN CLDN9 CLDN9 MAPK12 MAPK12 PTK2B PTK2B MYL2 MYL2 PIK3R1 PIK3R1 MAPK11 MAPK11 LOC111186386 LOC111186386 ITGB2 ITGB2 LOC111187847 LOC111187847 PTPN11 PTPN11 LOC111187198 LOC111187198 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYL12BMyosin regulatory light chain 12B. (172 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
LOC111162912Myosin regulatory light chain 12B. (171 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
ARHGAP5Rho GTPase-activating protein 5. (1503 aa)
CTNNA2Catenin alpha-2. (865 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
MMP272 kDa type IV collagenase. (661 aa)
EZREzrin. (586 aa)
ESAMLOW QUALITY PROTEIN: endothelial cell-selective adhesion molecule. (396 aa)
JAM3Junctional adhesion molecule C. (301 aa)
AFDNAfadin isoform X1. (1794 aa)
CD99CD99 antigen isoform X1. (200 aa)
CLDN25LOW QUALITY PROTEIN: putative claudin-25. (230 aa)
XGGlycoprotein Xg. (140 aa)
CTNNB1Catenin beta-1. (781 aa)
CD99L2CD99 antigen-like protein 2 isoform X1. (300 aa)
F11RJunctional adhesion molecule A. (299 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
MSNMoesin isoform X1. (579 aa)
ACTBActin, cytoplasmic 1. (375 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
TXKTyrosine-protein kinase. (550 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
LOC111170450Cytochrome b-245 heavy chain isoform X1. (570 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (293 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
ACTN1Alpha-actinin-1 isoform X2. (914 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
JAM2Junctional adhesion molecule B isoform X1. (350 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
LOC111173597Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
RHOATransforming protein RhoA. (193 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (254 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC111178986LOW QUALITY PROTEIN: catenin alpha-1-like. (908 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LOC111179403Cytochrome b-245 light chain isoform X1. (202 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
VCAM1Vascular cell adhesion protein 1. (739 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (384 aa)
ACTN4Alpha-actinin-4 isoform X5. (933 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
NCF1Neutrophil cytosol factor 1 isoform X2. (405 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform. (170 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (872 aa)
MYL10Myosin regulatory light chain 10. (147 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CTNNA1Catenin alpha-1. (906 aa)
PRKCBProtein kinase C. (689 aa)
ITKTyrosine-protein kinase. (620 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CTNNA3Catenin alpha-3. (944 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1166 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (701 aa)
CTNND1Catenin delta-1 isoform X1. (961 aa)
SIPA1Signal-induced proliferation-associated protein 1. (1182 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
RASSF5Ras association domain-containing protein 5 isoform X1. (422 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
MYL7Myosin regulatory light chain 2, atrial isoform isoform X1. (176 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
LOC111186386Neutrophil cytosol factor 4-like. (250 aa)
ITGB2Integrin beta. (769 aa)
LOC111187847Neutrophil cytosol factor 4 isoform X2. (339 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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