STRINGSTRING
GRIN2A GRIN2A MAPK1 MAPK1 RPS6KA1 RPS6KA1 ADCY8 ADCY8 PLCB1 PLCB1 PLCB4 PLCB4 MAP2K2 MAP2K2 GRM1 GRM1 ARAF ARAF PRKACA PRKACA RPS6KA3 RPS6KA3 HRAS HRAS RPS6KA2 RPS6KA2 RAF1 RAF1 PPP3CC PPP3CC RAPGEF3 RAPGEF3 PPP1R1A PPP1R1A ITPR1 ITPR1 PPP1CB PPP1CB RAP1B RAP1B KRAS KRAS ITPR2 ITPR2 CACNA1C CACNA1C GNAQ GNAQ CALML4 CALML4 GRIN2B GRIN2B BRAF BRAF CALM1 CALM1 PRKACB PRKACB GRIN1 GRIN1 RPS6KA6 RPS6KA6 MAP2K1 MAP2K1 GRIN2D GRIN2D ITPR3 ITPR3 RAP1A RAP1A PPP3CA PPP3CA PLCB2 PLCB2 NRAS NRAS MAPK3 MAPK3 PRKCB PRKCB GRIN2C GRIN2C CAMK2G CAMK2G PRKCA PRKCA PPP1CA PPP1CA GRIA1 GRIA1 PPP3CB PPP3CB PLCB3 PLCB3 CAMK2A CAMK2A ADCY1 ADCY1 CAMK2D CAMK2D CREBBP CREBBP ATF4 ATF4 CAMK2B CAMK2B GRM5 GRM5 EP300 EP300 PPP1CC PPP1CC CALML6 CALML6 PPP3R1 PPP3R1 PPP3R2 PPP3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1464 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
RPS6KA1Ribosomal protein S6 kinase. (783 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
GRM1Metabotropic glutamate receptor 1. (1195 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
HRASGTPase HRas isoform X1. (189 aa)
RPS6KA2Ribosomal protein S6 kinase. (780 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
PPP3CCSerine/threonine-protein phosphatase. (522 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
PPP1R1AProtein phosphatase 1 regulatory subunit 1A isoform X1. (215 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
KRASGTPase KRas. (188 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1499 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (959 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GRIN2DLOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D. (1334 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NRASGTPase NRas. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C isoform X1. (1265 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GRIA1Glutamate receptor 1 isoform X1. (906 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1208 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.