STRINGSTRING
CRKL CRKL CDC42 CDC42 MAPK1 MAPK1 RPS6KA1 RPS6KA1 KIDINS220 KIDINS220 FOXO3 FOXO3 MAP2K2 MAP2K2 MAP2K7 MAP2K7 NGFR NGFR NTRK2 NTRK2 PIK3R2 PIK3R2 SHC1 SHC1 NTRK1 NTRK1 MATK MATK RPS6KA3 RPS6KA3 SHC3 SHC3 MAPK10 MAPK10 MAP3K5 MAP3K5 NTRK3 NTRK3 GSK3B GSK3B FASLG FASLG ZNF274 ZNF274 HRAS HRAS RPS6KA2 RPS6KA2 IRAK1 IRAK1 MAPK9 MAPK9 MAPK8 MAPK8 BEX3 BEX3 IRS1 IRS1 IRAK2 IRAK2 RAF1 RAF1 SHC2 SHC2 FRS2 FRS2 MAGED1 MAGED1 SOS2 SOS2 PIK3CA PIK3CA IKBKB IKBKB IRAK4 IRAK4 SOS1 SOS1 PIK3R3 PIK3R3 PRKCD PRKCD NFKBIA NFKBIA JUN JUN RHOA RHOA AKT1 AKT1 RPS6KA5 RPS6KA5 RAP1B RAP1B NTF3 NTF3 ARHGDIB ARHGDIB KRAS KRAS RAPGEF1 RAPGEF1 AKT3 AKT3 CALML4 CALML4 PSEN2 PSEN2 MAPK14 MAPK14 BRAF BRAF CALM1 CALM1 PSEN1 PSEN1 MAPK13 MAPK13 NFKBIE NFKBIE MAP2K5 MAP2K5 ABL1 ABL1 PLCG2 PLCG2 PIK3CB PIK3CB RPS6KA6 RPS6KA6 MAP2K1 MAP2K1 SORT1 SORT1 BDNF BDNF NFKBIB NFKBIB RAP1A RAP1A NFKB1 NFKB1 BAX BAX BCL2 BCL2 TRAF6 TRAF6 NGF NGF NRAS NRAS NTF4 NTF4 AKT2 AKT2 MAPK3 MAPK3 SH2B1 SH2B1 CAMK2G CAMK2G GRB2 GRB2 SHC4 SHC4 SH2B2 SH2B2 RAC1 RAC1 PLCG1 PLCG1 MAP3K3 MAP3K3 ARHGDIA ARHGDIA RELA RELA CAMK2A CAMK2A MAPKAPK2 MAPKAPK2 BAD BAD CRK CRK CAMK2D CAMK2D ATF4 ATF4 CAMK2B CAMK2B SH2B3 SH2B3 ARHGDIG ARHGDIG PDPK1 PDPK1 MAPK12 MAPK12 MAP3K1 MAP3K1 YWHAE YWHAE TP73 TP73 PIK3R1 PIK3R1 CALML6 CALML6 MAPK11 MAPK11 GAB1 GAB1 PRDM4 PRDM4 PTPN11 PTPN11 LOC111187198 LOC111187198 PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCrk-like protein. (303 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
RPS6KA1Ribosomal protein S6 kinase. (783 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X1. (1793 aa)
FOXO3Forkhead box protein O3. (672 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
MATKTyrosine-protein kinase. (706 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SHC3SHC-transforming protein 3. (588 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
ZNF274Neurotrophin receptor-interacting factor homolog isoform X1. (697 aa)
HRASGTPase HRas isoform X1. (189 aa)
RPS6KA2Ribosomal protein S6 kinase. (780 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BEX3Protein BEX3 isoform X1. (112 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
IRAK2LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase-like 2. (621 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
MAGED1Melanoma-associated antigen D1 isoform X1. (841 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (265 aa)
ARHGDIBRho GDP-dissociation inhibitor 2. (199 aa)
KRASGTPase KRas. (188 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (512 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
NFKBIENF-kappa-B inhibitor epsilon isoform X1. (365 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X3; Belongs to the protein kinase superfamily. (448 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SORT1Sortilin. (864 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
NRASGTPase NRas. (189 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (247 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SH2B1SH2B adapter protein 1 isoform X1. (795 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
SH2B2SH2B adapter protein 2 isoform X1. (703 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (657 aa)
ARHGDIARho GDP-dissociation inhibitor 1. (204 aa)
RELATranscription factor p65 isoform X1. (562 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
MAPKAPK2LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (414 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
SH2B3SH2B adapter protein 3 isoform X1. (618 aa)
ARHGDIGRho GDP-dissociation inhibitor 3. (225 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1 isoform X1. (1508 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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