STRINGSTRING
CDC42 CDC42 MAPK1 MAPK1 ADCY4 ADCY4 ADCY8 ADCY8 ADCY7 ADCY7 PLCB1 PLCB1 ELK1 ELK1 PLCB4 PLCB4 MAP2K2 MAP2K2 MAP2K7 MAP2K7 MMP14 MMP14 GNA11 GNA11 PRKACA PRKACA MMP2 MMP2 CACNA1S CACNA1S MAPK10 MAPK10 GNRHR GNRHR CGA CGA CACNA1F CACNA1F MAP2K3 MAP2K3 MAP3K4 MAP3K4 HRAS HRAS MAPK9 MAPK9 MAPK8 MAPK8 RAF1 RAF1 ADCY5 ADCY5 SOS2 SOS2 ITPR1 ITPR1 PLD1 PLD1 ADCY3 ADCY3 SOS1 SOS1 CACNA1D CACNA1D PRKCD PRKCD JUN JUN KRAS KRAS ITPR2 ITPR2 ADCY6 ADCY6 CACNA1C CACNA1C GNAQ GNAQ CALML4 CALML4 MAPK14 MAPK14 CALM1 CALM1 MAPK13 MAPK13 PRKACB PRKACB FSHB FSHB MAP2K1 MAP2K1 ITPR3 ITPR3 LHB LHB ADCY2 ADCY2 PLA2G4F PLA2G4F PLCB2 PLCB2 NRAS NRAS EGR1 EGR1 PLA2G4E PLA2G4E MAPK3 MAPK3 HBEGF HBEGF PRKCB PRKCB MAP3K2 MAP3K2 CAMK2G CAMK2G MAP2K6 MAP2K6 PRKCA PRKCA GRB2 GRB2 MAP3K3 MAP3K3 PLCB3 PLCB3 CAMK2A CAMK2A SRC SRC GNRH2 GNRH2 ADCY1 ADCY1 PLD2 PLD2 MAP2K4 MAP2K4 CAMK2D CAMK2D ATF4 ATF4 CAMK2B CAMK2B EGFR EGFR PLA2G4A PLA2G4A ADCY9 ADCY9 MAPK12 MAPK12 PTK2B PTK2B GNRH1 GNRH1 MAP3K1 MAP3K1 CALML6 CALML6 MAPK11 MAPK11 GNAS GNAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ELK1LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1. (442 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MMP272 kDa type IV collagenase. (661 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
GNRHRGonadotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (328 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1911 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1601 aa)
HRASGTPase HRas isoform X1. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
PLD1Phospholipase. (1151 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
KRASGTPase KRas. (188 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
FSHBFollitropin subunit beta. (129 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
LHBLutropin subunit beta. (141 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
PLA2G4FPhospholipase A2. (849 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NRASGTPase NRas. (189 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
PLA2G4EPhospholipase A2. (868 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
PRKCBProtein kinase C. (689 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (620 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (657 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
SRCTyrosine-protein kinase. (562 aa)
GNRH2Progonadoliberin-2. (105 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
PLD2Phospholipase. (933 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLA2G4APhospholipase A2. (749 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (97 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1 isoform X1. (1508 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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