STRINGSTRING
MAPK1 MAPK1 ADCY4 ADCY4 ADCY8 ADCY8 ADCY7 ADCY7 TFF1 TFF1 KCNJ6 KCNJ6 PLCB1 PLCB1 GNAI1 GNAI1 PLCB4 PLCB4 MAP2K2 MAP2K2 LOC111166410 LOC111166410 LOC111166492 LOC111166492 LOC111166499 LOC111166499 LOC111166379 LOC111166379 LOC111166411 LOC111166411 GNAO1 GNAO1 KRT36 KRT36 LOC111166500 LOC111166500 GRM1 GRM1 PIK3R2 PIK3R2 LOC111166381 LOC111166381 LOC111166494 LOC111166494 SHC1 SHC1 PRKACA PRKACA MMP2 MMP2 OPRM1 OPRM1 CREB3L4 CREB3L4 ESR1 ESR1 LOC111166317 LOC111166317 KCNJ9 KCNJ9 KCNJ5 KCNJ5 TGFA TGFA SHC3 SHC3 PGR PGR GABBR1 GABBR1 CREB3L3 CREB3L3 LOC111166378 LOC111166378 GPER1 GPER1 NCOA3 NCOA3 HSPA8 HSPA8 CTSD CTSD HRAS HRAS LOC111170664 LOC111170664 LOC111170662 LOC111170662 ATF6B ATF6B RAF1 RAF1 MMP9 MMP9 ADCY5 ADCY5 KCNJ3 KCNJ3 ESR2 ESR2 HSPA6 HSPA6 SHC2 SHC2 CREB1 CREB1 SOS2 SOS2 PIK3CA PIK3CA ITPR1 ITPR1 GNAI2 GNAI2 SP1 SP1 HSPA2 HSPA2 ADCY3 ADCY3 NCOA1 NCOA1 SOS1 SOS1 KRT18 KRT18 ATF2 ATF2 POMC POMC HSP90AA1 HSP90AA1 PIK3R3 PIK3R3 PRKCD PRKCD JUN JUN AKT1 AKT1 NOS3 NOS3 KRAS KRAS ITPR2 ITPR2 ADCY6 ADCY6 FOS FOS GNAQ GNAQ AKT3 AKT3 CALML4 CALML4 FKBP5 FKBP5 CALM1 CALM1 FKBP4 FKBP4 PRKACB PRKACB CREB3L2 CREB3L2 PIK3CB PIK3CB MAP2K1 MAP2K1 ITPR3 ITPR3 HSP90AB1 HSP90AB1 ADCY2 ADCY2 BCL2 BCL2 CREB5 CREB5 PLCB2 PLCB2 NRAS NRAS GNAI3 GNAI3 EBAG9 EBAG9 AKT2 AKT2 MAPK3 MAPK3 HBEGF HBEGF GRB2 GRB2 SHC4 SHC4 PLCB3 PLCB3 CREB3L1 CREB3L1 SRC SRC ADCY1 ADCY1 NCOA2 NCOA2 ATF4 ATF4 EGFR EGFR ADCY9 ADCY9 PIK3R1 PIK3R1 CALML6 CALML6 GNAS GNAS GABBR2 GABBR2 PIK3CD PIK3CD HSP90B1 HSP90B1 CREB3 CREB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
TFF1Trefoil factor 1. (127 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
LOC111166410Keratin, type I cytoskeletal 15; Belongs to the intermediate filament family. (443 aa)
LOC111166492Keratin, type I cytoskeletal 12-like; Belongs to the intermediate filament family. (484 aa)
LOC111166499LOW QUALITY PROTEIN: keratin, type I cuticular Ha5-like; Belongs to the intermediate filament family. (450 aa)
LOC111166379LOW QUALITY PROTEIN: keratin, type I cytoskeletal 42-like; Belongs to the intermediate filament family. (347 aa)
LOC111166411Keratin, type I cytoskeletal 19; Belongs to the intermediate filament family. (400 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform X1. (354 aa)
KRT36Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. (459 aa)
LOC111166500LOW QUALITY PROTEIN: keratin, type I microfibrillar 48 kDa, component 8C-1-like; Belongs to the intermediate filament family. (448 aa)
GRM1Metabotropic glutamate receptor 1. (1195 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LOC111166381Keratin, type I cytoskeletal 14-like; Belongs to the intermediate filament family. (376 aa)
LOC111166494LOW QUALITY PROTEIN: keratin, type I cuticular Ha2-like; Belongs to the intermediate filament family. (464 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
MMP272 kDa type IV collagenase. (661 aa)
OPRM1Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (462 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
LOC111166317Keratin, type I cytoskeletal 13-like; Belongs to the intermediate filament family. (416 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3 isoform X1. (453 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
SHC3SHC-transforming protein 3. (588 aa)
PGRProgesterone receptor. (936 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (965 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
LOC111166378Keratin, type I cytoskeletal 17-like isoform X1; Belongs to the intermediate filament family. (453 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
NCOA3Nuclear receptor coactivator. (1406 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (650 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (411 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC111170664Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
LOC111170662Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (641 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
ESR2Estrogen receptor beta. (558 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6; Belongs to the heat shock protein 70 family. (645 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
SP1Transcription factor Sp1. (786 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (638 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
KRT18Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (429 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
POMCPro-opiomelanocortin. (261 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
KRASGTPase KRas. (188 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
FOSProto-oncogene c-Fos. (380 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
FKBP4Peptidylprolyl isomerase. (458 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NRASGTPase NRas. (189 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells isoform X2. (336 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
SRCTyrosine-protein kinase. (562 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
HSP90B1Endoplasmin. (805 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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