STRINGSTRING
WNT4 WNT4 MAPK1 MAPK1 KITLG KITLG ADCY4 ADCY4 ADCY8 ADCY8 ADCY7 ADCY7 PLCB1 PLCB1 GNAI1 GNAI1 PLCB4 PLCB4 MAP2K2 MAP2K2 GNAO1 GNAO1 TCF7L1 TCF7L1 PRKACA PRKACA CREB3L4 CREB3L4 CREB3L3 CREB3L3 WNT7A WNT7A CTNNB1 CTNNB1 WNT3A WNT3A KIT KIT GSK3B GSK3B HRAS HRAS LEF1 LEF1 FZD5 FZD5 RAF1 RAF1 WNT10A WNT10A FZD2 FZD2 WNT9A WNT9A ADCY5 ADCY5 CREB1 CREB1 TCF7L2 TCF7L2 MITF MITF FZD7 FZD7 GNAI2 GNAI2 WNT6 WNT6 ADCY3 ADCY3 WNT5A WNT5A WNT10B WNT10B POMC POMC DVL3 DVL3 KRAS KRAS ADCY6 ADCY6 WNT1 WNT1 GNAQ GNAQ WNT5B WNT5B CALML4 CALML4 EDNRB EDNRB FZD8 FZD8 CALM1 CALM1 DCT DCT PRKACB PRKACB CREB3L2 CREB3L2 MAP2K1 MAP2K1 WNT2B WNT2B ADCY2 ADCY2 FZD1 FZD1 WNT2 WNT2 FZD6 FZD6 WNT16 WNT16 PLCB2 PLCB2 NRAS NRAS GNAI3 GNAI3 FZD9 FZD9 TCF7 TCF7 MAPK3 MAPK3 WNT8A WNT8A WNT3 WNT3 PRKCB PRKCB EDN1 EDN1 CAMK2G CAMK2G PRKCA PRKCA PLCB3 PLCB3 CREB3L1 CREB3L1 CAMK2A CAMK2A WNT11 WNT11 ADCY1 ADCY1 TYR TYR FZD4 FZD4 ASIP ASIP CAMK2D CAMK2D FZD3 FZD3 CREBBP CREBBP CAMK2B CAMK2B ADCY9 ADCY9 WNT7B WNT7B EP300 EP300 DVL2 DVL2 FZD10 FZD10 DVL1 DVL1 CALML6 CALML6 GNAS GNAS CREB3 CREB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
KITLGKit ligand isoform X1. (295 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform X1. (354 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (601 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HRASGTPase HRas isoform X1. (189 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
POMCPro-opiomelanocortin. (261 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X3. (731 aa)
KRASGTPase KRas. (188 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
DCTL-dopachrome tautomerase. (517 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NRASGTPase NRas. (189 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
TCF7Transcription factor 7 isoform X1. (415 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
PRKCBProtein kinase C. (689 aa)
EDN1Endothelin-1. (202 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
TYRTyrosinase. (530 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
ASIPAgouti-signaling protein isoform X1. (175 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
EP300Histone acetyltransferase p300. (2420 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (12%) [HD]