STRINGSTRING
WNT4 WNT4 MAPK1 MAPK1 SLC9A1 SLC9A1 MED13 MED13 RCAN1 RCAN1 PLCD1 PLCD1 MYC MYC THRB THRB SLC16A10 SLC16A10 KAT2B KAT2B LOC111164829 LOC111164829 PLCB1 PLCB1 PFKP PFKP PLCB4 PLCB4 MAP2K2 MAP2K2 MED24 MED24 PIK3R2 PIK3R2 MED1 MED1 THRA THRA FXYD2 FXYD2 LOC111164824 LOC111164824 PRKACA PRKACA LOC111166987 LOC111166987 PLN PLN ATP1B1 ATP1B1 MED30 MED30 LOC111166986 LOC111166986 ESR1 ESR1 KAT2A KAT2A MED14 MED14 NCOR1 NCOR1 MED17 MED17 NOTCH3 NOTCH3 CTNNB1 CTNNB1 GSK3B GSK3B NCOA3 NCOA3 ATP1B4 ATP1B4 ACTB ACTB MED16 MED16 HRAS HRAS MED12 MED12 NOTCH4 NOTCH4 RAF1 RAF1 RXRG RXRG ITGAV ITGAV STAT1 STAT1 PLCD3 PLCD3 BMP4 BMP4 PLCD4 PLCD4 HIF1A HIF1A PIK3CA PIK3CA PFKM PFKM NCOA1 NCOA1 FOXO1 FOXO1 PLCE1 PLCE1 HDAC1 HDAC1 DIO1 DIO1 PIK3R3 PIK3R3 AKT1 AKT1 MDM2 MDM2 RHEB RHEB SLCO1C1 SLCO1C1 KRAS KRAS DIO3 DIO3 MED4 MED4 PLCZ1 PLCZ1 AKT3 AKT3 RXRA RXRA TBC1D4 TBC1D4 SLC2A1 SLC2A1 SIN3A SIN3A PRKACB PRKACB NOTCH1 NOTCH1 MED27 MED27 ATP1A1 ATP1A1 PLCG2 PLCG2 RCAN2 RCAN2 PIK3CB PIK3CB SLC16A2 SLC16A2 MAP2K1 MAP2K1 ATP1B3 ATP1B3 RXRB RXRB MED12L MED12L PLCB2 PLCB2 NOTCH2 NOTCH2 NRAS NRAS ITGB3 ITGB3 ATP1A3 ATP1A3 AKT2 AKT2 MAPK3 MAPK3 PRKCB PRKCB PRKCA PRKCA ACTG1 ACTG1 PLCG1 PLCG1 ATP2A1 ATP2A1 CCND1 CCND1 PLCB3 PLCB3 PFKFB2 PFKFB2 HDAC3 HDAC3 SRC SRC NCOA2 NCOA2 BAD BAD ATP1B2 ATP1B2 GATA4 GATA4 CREBBP CREBBP ATP2A3 ATP2A3 MED13L MED13L TSC2 TSC2 PDPK1 PDPK1 PFKL PFKL CASP9 CASP9 EP300 EP300 PIK3R1 PIK3R1 MTOR MTOR ATP2A2 ATP2A2 PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2174 aa)
RCAN1Calcipressin-1 isoform X1. (246 aa)
PLCD1Phosphoinositide phospholipase C. (817 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
THRBThyroid hormone receptor beta isoform X3. (476 aa)
SLC16A10Monocarboxylate transporter 10. (397 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (828 aa)
LOC111164829Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (473 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (809 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MED24Mediator of RNA polymerase II transcription subunit 24 isoform X1. (1018 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
THRAThyroid hormone receptor alpha. (410 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (107 aa)
LOC111164824Histone deacetylase 2-like isoform X1. (260 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LOC111166987Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
MED30Mediator of RNA polymerase II transcription subunit 30. (178 aa)
LOC111166986Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (878 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1453 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2454 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
NOTCH3Neurogenic locus notch homolog protein 3 isoform X1. (2336 aa)
CTNNB1Catenin beta-1. (781 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
NCOA3Nuclear receptor coactivator. (1406 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
ACTBActin, cytoplasmic 1. (375 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (829 aa)
HRASGTPase HRas isoform X1. (189 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2177 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
PLCD4Phosphoinositide phospholipase C. (821 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
FOXO1Forkhead box protein O1. (663 aa)
PLCE1Phosphoinositide phospholipase C. (1811 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
DIO1Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (249 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
RHEBGTP-binding protein Rheb. (184 aa)
SLCO1C1Solute carrier organic anion transporter family member. (712 aa)
KRASGTPase KRas. (188 aa)
DIO3Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (304 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (270 aa)
PLCZ1Phosphoinositide phospholipase C. (502 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (495 aa)
TBC1D4TBC1 domain family member 4 isoform X4. (1300 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
SIN3APaired amphipathic helix protein Sin3a. (1274 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
MED27Mediator of RNA polymerase II transcription subunit 27 isoform X1. (311 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
RCAN2Calcipressin-2 isoform X1. (243 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SLC16A2Monocarboxylate transporter 8 isoform X1. (539 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (538 aa)
MED12LMediator of RNA polymerase II transcription subunit 12-like protein isoform X1. (2199 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
NRASGTPase NRas. (189 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1006 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1. (554 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
SRCTyrosine-protein kinase. (562 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
BADBcl2-associated agonist of cell death. (168 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
GATA4Transcription factor GATA-4 isoform X1. (437 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1057 aa)
MED13LMediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2225 aa)
TSC2Tuberin isoform X8. (1815 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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