STRINGSTRING
AGTR1 AGTR1 AGT AGT ATP2B1 ATP2B1 PRKD1 PRKD1 ADCY4 ADCY4 MC2R MC2R ADCY8 ADCY8 ADCY7 ADCY7 KCNK9 KCNK9 PLCB1 PLCB1 PLCB4 PLCB4 CACNA1G CACNA1G GNA11 GNA11 PRKACA PRKACA LOC111166987 LOC111166987 CREB3L4 CREB3L4 ATP1B1 ATP1B1 LOC111166986 LOC111166986 KCNJ5 KCNJ5 LDLR LDLR CACNA1S CACNA1S CREB3L3 CREB3L3 NPR1 NPR1 CACNA1F CACNA1F ATP1B4 ATP1B4 ATF6B ATF6B ADCY5 ADCY5 LOC111170705 LOC111170705 CREB1 CREB1 ATP2B3 ATP2B3 NR4A2 NR4A2 ITPR1 ITPR1 ATF1 ATF1 PRKD3 PRKD3 ADCY3 ADCY3 PRKCE PRKCE CACNA1D CACNA1D ATF2 ATF2 POMC POMC KCNK3 KCNK3 STAR STAR NR4A1 NR4A1 ITPR2 ITPR2 ADCY6 ADCY6 CACNA1C CACNA1C GNAQ GNAQ CALML4 CALML4 CAMK1D CAMK1D CALM1 CALM1 PRKACB PRKACB LOC111177811 LOC111177811 ATP1A1 ATP1A1 CREB3L2 CREB3L2 PRKD2 PRKD2 ITPR3 ITPR3 LOC111179902 LOC111179902 ADCY2 ADCY2 ATP1B3 ATP1B3 LIPE LIPE CREB5 CREB5 PLCB2 PLCB2 ATP1A3 ATP1A3 PRKCB PRKCB CAMK2G CAMK2G PRKCA PRKCA DAGLB DAGLB PLCB3 PLCB3 CREB3L1 CREB3L1 CAMK2A CAMK2A PDE2A PDE2A ADCY1 ADCY1 ATP2B4 ATP2B4 DAGLA DAGLA CACNA1H CACNA1H ATP1B2 ATP1B2 CAMK2D CAMK2D ATF4 ATF4 CACNA1I CACNA1I CAMK2B CAMK2B CAMK1G CAMK1G ADCY9 ADCY9 ORAI1 ORAI1 SCARB1 SCARB1 CALML6 CALML6 GNAS GNAS NPPA NPPA CREB3 CREB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1258 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
KCNK9Potassium channel subfamily K member. (374 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2382 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LOC111166987Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
LOC111166986Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
NPR1Guanylate cyclase. (1065 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1911 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
LOC111170705Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (495 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1248 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (336 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
PRKCEProtein kinase C. (746 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
POMCPro-opiomelanocortin. (261 aa)
KCNK3Potassium channel subfamily K member. (398 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (593 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D isoform X1. (435 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
LOC111177811Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
LOC1111799023 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. (373 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
LIPEHormone-sensitive lipase isoform X1. (799 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
PRKCBProtein kinase C. (689 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
DAGLBSn1-specific diacylglycerol lipase beta isoform X1. (669 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
PDE2APhosphodiesterase. (971 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
DAGLASn1-specific diacylglycerol lipase alpha isoform X1. (1040 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H isoform X1. (2335 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2193 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G; Belongs to the protein kinase superfamily. (476 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ORAI1Calcium release-activated calcium channel protein 1. (410 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (511 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
NPPANatriuretic peptides A. (152 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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