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AGTR1 AGTR1 MRAP MRAP AGT AGT ADCY4 ADCY4 MC2R MC2R ADCY8 ADCY8 PDE8A PDE8A ADCY7 ADCY7 PLCB1 PLCB1 PLCB4 PLCB4 LOC111165107 LOC111165107 CACNA1G CACNA1G GNA11 GNA11 PRKACA PRKACA CREB3L4 CREB3L4 LDLR LDLR CACNA1S CACNA1S CREB3L3 CREB3L3 CACNA1F CACNA1F NR0B1 NR0B1 PBX1 PBX1 ATF6B ATF6B ADCY5 ADCY5 LOC111170705 LOC111170705 LOC111172355 LOC111172355 CREB1 CREB1 ITPR1 ITPR1 SP1 SP1 NCEH1 NCEH1 ADCY3 ADCY3 CACNA1D CACNA1D ATF2 ATF2 POMC POMC KCNK3 KCNK3 STAR STAR NR4A1 NR4A1 ITPR2 ITPR2 ADCY6 ADCY6 NR5A1 NR5A1 CACNA1C CACNA1C GNAQ GNAQ PRKACB PRKACB LOC111177811 LOC111177811 CREB3L2 CREB3L2 ITPR3 ITPR3 KCNA4 KCNA4 LOC111179902 LOC111179902 ADCY2 ADCY2 CREB5 CREB5 PLCB2 PLCB2 PLCB3 PLCB3 KCNK2 KCNK2 CREB3L1 CREB3L1 PDE8B PDE8B ADCY1 ADCY1 CACNA1H CACNA1H ATF4 ATF4 CACNA1I CACNA1I ADCY9 ADCY9 ORAI1 ORAI1 SCARB1 SCARB1 GNAS GNAS CREB3 CREB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
MRAPMelanocortin-2 receptor accessory protein isoform X1. (197 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PDE8APhosphodiesterase. (657 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LOC111165107Cytochrome P450 11B1, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (503 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2382 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1911 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (464 aa)
PBX1pre-B-cell leukemia transcription factor 1 isoform X1. (430 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
LOC111170705Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (495 aa)
LOC111172355Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (509 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
SP1Transcription factor Sp1. (786 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
POMCPro-opiomelanocortin. (261 aa)
KCNK3Potassium channel subfamily K member. (398 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (593 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
NR5A1Steroidogenic factor 1 isoform X1. (461 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
LOC111177811Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (663 aa)
LOC1111799023 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. (373 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
KCNK2Potassium channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (427 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PDE8BPhosphodiesterase. (885 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H isoform X1. (2335 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2193 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ORAI1Calcium release-activated calcium channel protein 1. (410 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (511 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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