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MAPK1 MAPK1 KCNJ6 KCNJ6 KCNJ11 KCNJ11 PLCB1 PLCB1 TRPC5 TRPC5 PLCB4 PLCB4 MAP2K2 MAP2K2 CACNA1G CACNA1G GNA11 GNA11 KCNN1 KCNN1 PIK3R2 PIK3R2 HCN3 HCN3 KCNJ9 KCNJ9 KCNJ5 KCNJ5 CACNA1S CACNA1S GABBR1 GABBR1 CGA CGA CACNA1F CACNA1F KCNN3 KCNN3 GPER1 GPER1 HRAS HRAS KISS1R KISS1R RAF1 RAF1 KCNJ3 KCNJ3 ESR2 ESR2 HCN2 HCN2 PIK3CA PIK3CA ITPR1 ITPR1 CACNA1D CACNA1D TRPC4 TRPC4 PIK3R3 PIK3R3 AKT1 AKT1 KRAS KRAS ITPR2 ITPR2 CACNA1C CACNA1C GNAQ GNAQ AKT3 AKT3 PIK3CB PIK3CB MAP2K1 MAP2K1 ITPR3 ITPR3 SPP1 SPP1 LHB LHB KCNN4 KCNN4 PLCB2 PLCB2 NRAS NRAS AKT2 AKT2 MAPK3 MAPK3 PRKCB PRKCB PRKCA PRKCA KCNN2 KCNN2 PLCB3 PLCB3 GNRH2 GNRH2 KISS1 KISS1 CACNA1H CACNA1H CACNA1I CACNA1I ARRB1 ARRB1 ARRB2 ARRB2 GNRH1 GNRH1 HCN1 HCN1 PIK3R1 PIK3R1 GABBR2 GABBR2 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (388 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
TRPC5Short transient receptor potential channel 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2382 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
KCNN1Small conductance calcium-activated potassium channel protein 1 isoform X3. (546 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
HCN3Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3. (786 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3 isoform X1. (453 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (965 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1911 aa)
KCNN3Small conductance calcium-activated potassium channel protein 3 isoform X1. (722 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
HRASGTPase HRas isoform X1. (189 aa)
KISS1RkiSS-1 receptor. (451 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
ESR2Estrogen receptor beta. (558 aa)
HCN2LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2. (904 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
TRPC4Short transient receptor potential channel 4; Belongs to the transient receptor (TC 1.A.4) family. (976 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KRASGTPase KRas. (188 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
SPP1Osteopontin. (362 aa)
LHBLutropin subunit beta. (141 aa)
KCNN4Intermediate conductance calcium-activated potassium channel protein 4. (428 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NRASGTPase NRas. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
KCNN2Small conductance calcium-activated potassium channel protein 2 isoform X2. (853 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GNRH2Progonadoliberin-2. (105 aa)
KISS1Metastasis-suppressor KiSS-1. (138 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H isoform X1. (2335 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2193 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (97 aa)
HCN1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1. (876 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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