STRINGSTRING
ADIPOQ ADIPOQ SOCS1 SOCS1 MAPK1 MAPK1 SOCS2 SOCS2 ABCC8 ABCC8 MAFA MAFA KCNJ11 KCNJ11 INSR INSR IRS4 IRS4 CACNA1E CACNA1E CACNA1G CACNA1G PIK3R2 PIK3R2 CACNA1A CACNA1A MAPK10 MAPK10 PKLR PKLR HK2 HK2 HK3 HK3 MAPK9 MAPK9 MAPK8 MAPK8 IRS1 IRS1 SOCS4 SOCS4 PIK3CA PIK3CA IKBKB IKBKB PRKCE PRKCE PDX1 PDX1 CACNA1D CACNA1D PIK3R3 PIK3R3 PRKCD PRKCD IRS2 IRS2 CACNA1B CACNA1B SLC2A2 SLC2A2 CACNA1C CACNA1C PKM PKM PIK3CB PIK3CB MAPK3 MAPK3 SOCS3 SOCS3 LOC111181964 LOC111181964 HKDC1 HKDC1 HK1 HK1 GCK GCK INS INS SLC2A4 SLC2A4 PIK3R1 PIK3R1 MTOR MTOR PRKCZ PRKCZ PIK3CD PIK3CD TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADIPOQC1Q and collagen domain containing adiponectin. (242 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
ABCC8ATP-binding cassette sub-family C member 8 isoform X1. (1699 aa)
MAFATranscription factor MafA isoform X1. (344 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (388 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2583 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2382 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2501 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
HK2Hexokinase-2. (917 aa)
HK3Hexokinase-3 isoform X1. (924 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
PRKCEProtein kinase C. (746 aa)
PDX1Pancreas/duodenum homeobox protein 1. (289 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (1749 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
LOC111181964Uncharacterized protein LOC111181964 isoform X1. (833 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (918 aa)
HK1Hexokinase-1 isoform X2. (935 aa)
GCKPhosphotransferase. (537 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.