STRINGSTRING
ACACB ACACB RPS6KA1 RPS6KA1 AGT AGT RPS6KB1 RPS6KB1 PCK2 PCK2 LOC111164621 LOC111164621 INSR INSR MLX MLX PPP1R3E PPP1R3E G6PC G6PC STAT3 STAT3 PIK3R2 PIK3R2 LOC111164620 LOC111164620 CRTC2 CRTC2 CREB3L4 CREB3L4 RPS6KA3 RPS6KA3 GFPT1 GFPT1 MAPK10 MAPK10 CREB3L3 CREB3L3 SLC27A1 SLC27A1 GFPT2 GFPT2 SREBF1 SREBF1 SLC27A3 SLC27A3 GSK3B GSK3B G6PC3 G6PC3 RPS6KA2 RPS6KA2 OGT OGT SLC27A5 SLC27A5 MAPK9 MAPK9 MAPK8 MAPK8 IRS1 IRS1 MGEA5 MGEA5 PPARGC1A PPARGC1A PYGL PYGL G6PC2 G6PC2 PPP1R3C PPP1R3C CREB1 CREB1 PPP1R3B PPP1R3B PRKAG3 PRKAG3 PIK3CA PIK3CA PRKAG1 PRKAG1 IKBKB IKBKB PRKCE PRKCE FOXO1 FOXO1 PTEN PTEN PPP1CB PPP1CB PTPRF PTPRF PIK3R3 PIK3R3 PRKCD PRKCD NFKBIA NFKBIA AKT1 AKT1 IRS2 IRS2 NOS3 NOS3 SLC2A2 SLC2A2 SLC27A4 SLC27A4 PRKAG2 PRKAG2 PRKAA2 PRKAA2 AKT3 AKT3 TBC1D4 TBC1D4 SLC2A1 SLC2A1 GYS2 GYS2 PRKCQ PRKCQ TNFRSF1A TNFRSF1A PTPA PTPA CREB3L2 CREB3L2 PIK3CB PIK3CB RPS6KA6 RPS6KA6 NFKB1 NFKB1 NR1H2 NR1H2 GYS1 GYS1 PRKAB2 PRKAB2 CREB5 CREB5 AKT2 AKT2 PPARGC1B PPARGC1B PRKCB PRKCB SLC27A2 SLC27A2 SOCS3 SOCS3 CPT1A CPT1A RPS6KB2 RPS6KB2 PPP1CA PPP1CA PPP1R3A PPP1R3A MLXIPL MLXIPL SLC27A6 SLC27A6 RELA RELA PYGM PYGM NR1H3 NR1H3 CREB3L1 CREB3L1 TRIB3 TRIB3 INS INS PYGB PYGB CPT1B CPT1B SLC2A4 SLC2A4 PPARA PPARA PDPK1 PDPK1 MLXIP MLXIP PPP1CC PPP1CC PIK3R1 PIK3R1 PRKAA1 PRKAA1 MTOR MTOR PRKCZ PRKCZ PCK1 PCK1 PPP1R3D PPP1R3D PTPN1 PTPN1 PRKAB1 PRKAB1 PTPN11 PTPN11 LOC111187198 LOC111187198 PIK3CD PIK3CD CREB3 CREB3 TNF TNF IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACACBacetyl-CoA carboxylase 2 isoform X1. (2456 aa)
RPS6KA1Ribosomal protein S6 kinase. (783 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (655 aa)
LOC111164621Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
MLXMax-like protein X isoform X1. (298 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E isoform X1. (280 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LOC111164620Platelet glycoprotein 4-like; Belongs to the CD36 family. (472 aa)
CRTC2CREB-regulated transcription coactivator 2 isoform X1. (701 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
GFPT1Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1. (681 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
SLC27A1Long-chain fatty acid transport protein 1 isoform X1. (675 aa)
GFPT2Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2. (682 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X1. (1213 aa)
SLC27A3Long-chain fatty acid transport protein 3 isoform X1. (678 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
RPS6KA2Ribosomal protein S6 kinase. (780 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
SLC27A5Bile acyl-CoA synthetase. (687 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
MGEA5Protein O-GlcNAcase. (916 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (854 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (366 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (330 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
PRKCEProtein kinase C. (746 aa)
FOXO1Forkhead box protein O1. (663 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1917 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (566 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
TBC1D4TBC1 domain family member 4 isoform X4. (1300 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
PRKCQProtein kinase C. (665 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (323 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (450 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X2. (272 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1. (1173 aa)
PRKCBProtein kinase C. (689 aa)
SLC27A2Very long-chain acyl-CoA synthetase isoform X1. (620 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1116 aa)
MLXIPLCarbohydrate-responsive element-binding protein isoform X1. (929 aa)
SLC27A6Long-chain fatty acid transport protein 6. (634 aa)
RELATranscription factor p65 isoform X1. (562 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (447 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family. (780 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
MLXIPMLX-interacting protein isoform X1. (939 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (687 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (298 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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