STRINGSTRING
AGTR1 AGTR1 LOC111163175 LOC111163175 WNT4 WNT4 MAPK1 MAPK1 E2F2 E2F2 MRAP MRAP AGT AGT ADCY4 ADCY4 MC2R MC2R CDKN2B CDKN2B ADCY8 ADCY8 PDE8A PDE8A ADCY7 ADCY7 PLCB1 PLCB1 GNAI1 GNAI1 PLCB4 PLCB4 MAP2K2 MAP2K2 LOC111165107 LOC111165107 CACNA1G CACNA1G GNA11 GNA11 TCF7L1 TCF7L1 PRKACA PRKACA CREB3L4 CREB3L4 LDLR LDLR CACNA1S CACNA1S CREB3L3 CREB3L3 WNT7A WNT7A CTNNB1 CTNNB1 CACNA1F CACNA1F KMT2A KMT2A WNT3A WNT3A GSK3B GSK3B PBX1 PBX1 ATF6B ATF6B LEF1 LEF1 FZD5 FZD5 WNT10A WNT10A FZD2 FZD2 WNT9A WNT9A ADCY5 ADCY5 ARNT ARNT LOC111170705 LOC111170705 PDE11A PDE11A LOC111172355 LOC111172355 WDR5B WDR5B CREB1 CREB1 CDK4 CDK4 TCF7L2 TCF7L2 CDK2 CDK2 ITPR1 ITPR1 KMT2D KMT2D FZD7 FZD7 GNAI2 GNAI2 SP1 SP1 NCEH1 NCEH1 WNT6 WNT6 ADCY3 ADCY3 WNT5A WNT5A CACNA1D CACNA1D ATF2 ATF2 WNT10B WNT10B POMC POMC KCNK3 KCNK3 DVL3 DVL3 ASH2L ASH2L STAR STAR RAP1B RAP1B NR4A1 NR4A1 ITPR2 ITPR2 ADCY6 ADCY6 NR5A1 NR5A1 WNT1 WNT1 CACNA1C CACNA1C GNAQ GNAQ WNT5B WNT5B FH FH WDR5 WDR5 FZD8 FZD8 CDKN2C CDKN2C BRAF BRAF CDKN1A CDKN1A PRKACB PRKACB CDKN1B CDKN1B LOC111177811 LOC111177811 CRHR2 CRHR2 CREB3L2 CREB3L2 MAP2K1 MAP2K1 ITPR3 ITPR3 KCNA4 KCNA4 LOC111179902 LOC111179902 CDK6 CDK6 WNT2B WNT2B RAP1A RAP1A ADCY2 ADCY2 FZD1 FZD1 WNT2 WNT2 FZD6 FZD6 CCNE2 CCNE2 CCNE1 CCNE1 WNT16 WNT16 CREB5 CREB5 PLCB2 PLCB2 GNAI3 GNAI3 FZD9 FZD9 TCF7 TCF7 CRHR1 CRHR1 ARMC5 ARMC5 MAPK3 MAPK3 WNT8A WNT8A WNT3 WNT3 USP8 USP8 CAMK2G CAMK2G E2F3 E2F3 AXIN2 AXIN2 CCND1 CCND1 APC APC PLCB3 PLCB3 AIP AIP MEN1 MEN1 KCNK2 KCNK2 CREB3L1 CREB3L1 CAMK2A CAMK2A WNT11 WNT11 PDE8B PDE8B ADCY1 ADCY1 RBBP5 RBBP5 FZD4 FZD4 CACNA1H CACNA1H AXIN1 AXIN1 E2F1 E2F1 CAMK2D CAMK2D FZD3 FZD3 ATF4 ATF4 CACNA1I CACNA1I CAMK2B CAMK2B EGFR EGFR AIPL1 AIPL1 ADCY9 ADCY9 WNT7B WNT7B DVL2 DVL2 ORAI1 ORAI1 FZD10 FZD10 SCARB1 SCARB1 DVL1 DVL1 GNAS GNAS CREB3 CREB3 AHR AHR
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTR1Type-1 Angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC111163175Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
MRAPMelanocortin-2 receptor accessory protein isoform X1. (197 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (131 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PDE8APhosphodiesterase. (657 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
LOC111165107Cytochrome P450 11B1, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (503 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2382 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (601 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CTNNB1Catenin beta-1. (781 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1911 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4012 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PBX1pre-B-cell leukemia transcription factor 1 isoform X1. (430 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
LOC111170705Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (495 aa)
PDE11APhosphodiesterase. (930 aa)
LOC111172355Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (509 aa)
WDR5BWD repeat-containing protein 5B. (364 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
KMT2DHistone-lysine N-methyltransferase 2D isoform X1. (5446 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
SP1Transcription factor Sp1. (786 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
POMCPro-opiomelanocortin. (261 aa)
KCNK3Potassium channel subfamily K member. (398 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X3. (731 aa)
ASH2Lset1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1. (631 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (593 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
NR5A1Steroidogenic factor 1 isoform X1. (461 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
FHFumarate hydratase, mitochondrial. (510 aa)
WDR5WD repeat-containing protein 5. (334 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LOC111177811Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
CRHR2Corticotropin-releasing factor receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (537 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (663 aa)
LOC1111799023 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. (373 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
CCNE1G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
TCF7Transcription factor 7 isoform X1. (415 aa)
CRHR1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (475 aa)
ARMC5Armadillo repeat-containing protein 5. (950 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8 isoform X1; Belongs to the peptidase C19 family. (1087 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
E2F3LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa)
AXIN2Axin-2 isoform X1. (843 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
APCAdenomatous polyposis coli protein isoform X1. (2864 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
AIPAH receptor-interacting protein isoform X1. (330 aa)
MEN1Menin isoform X1. (616 aa)
KCNK2Potassium channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (427 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PDE8BPhosphodiesterase. (885 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
RBBP5Retinoblastoma-binding protein 5 isoform X1. (538 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H isoform X1. (2335 aa)
AXIN1Axin-1 isoform X1. (866 aa)
E2F1Transcription factor E2F1. (437 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2193 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
AIPL1Aryl-hydrocarbon-interacting protein-like 1. (328 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
ORAI1Calcium release-activated calcium channel protein 1. (410 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (511 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
AHRAryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] (845 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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