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GNGT2 GNGT2 GRIN2A GRIN2A MAPK1 MAPK1 GNG4 GNG4 LOC111164170 LOC111164170 LOC111164829 LOC111164829 ADORA2A ADORA2A GNAI1 GNAI1 GNAO1 GNAO1 PPP1R1B PPP1R1B GNG14 GNG14 NTRK2 NTRK2 ARAF ARAF MAOA MAOA LOC111164824 LOC111164824 DRD2 DRD2 SHC1 SHC1 PRKACA PRKACA CREB3L4 CREB3L4 MAOB MAOB ADORA2B ADORA2B SHC3 SHC3 LOC111168444 LOC111168444 LOC111168449 LOC111168449 LOC111168519 LOC111168519 LOC111168524 LOC111168524 LOC111168528 LOC111168528 LOC111168549 LOC111168549 CREB3L3 CREB3L3 LOC111168445 LOC111168445 LOC111168515 LOC111168515 LOC111168520 LOC111168520 LOC111168525 LOC111168525 LOC111168529 LOC111168529 LOC111168512 LOC111168512 LOC111168516 LOC111168516 LOC111168521 LOC111168521 LOC111168526 LOC111168526 LOC111168530 LOC111168530 HDAC6 HDAC6 SLC18A1 SLC18A1 LOC111169737 LOC111169737 LOC111169749 LOC111169749 LOC111167415 LOC111167415 LOC111168446 LOC111168446 LOC111168460 LOC111168460 HDAC5 HDAC5 LOC111168517 LOC111168517 LOC111168527 LOC111168527 LOC111168531 LOC111168531 LOC111168543 LOC111168543 HRAS HRAS LOC111167944 LOC111167944 LOC111169314 LOC111169314 ATF6B ATF6B LOC111168443 LOC111168443 LOC111168448 LOC111168448 LOC111169704 LOC111169704 LOC111168514 LOC111168514 LOC111168523 LOC111168523 LOC111168544 LOC111168544 LOC111168550 LOC111168550 LOC111169747 LOC111169747 HDAC11 HDAC11 RAF1 RAF1 LOC111171120 LOC111171120 LOC111171154 LOC111171154 LOC111169315 LOC111169315 ADCY5 ADCY5 SLC18A2 SLC18A2 GRIN3B GRIN3B LOC111169736 LOC111169736 LOC111169748 LOC111169748 GNG7 GNG7 LOC111171155 LOC111171155 HDAC8 HDAC8 SHC2 SHC2 CREB1 CREB1 HDAC4 HDAC4 HAT1 HAT1 SOS2 SOS2 HDAC7 HDAC7 GNB4 GNB4 GNAI2 GNAI2 SOS1 SOS1 HDAC1 HDAC1 ATF2 ATF2 PPP1CB PPP1CB GNG2 GNG2 LOC111176743 LOC111176743 LOC111176794 LOC111176794 KRAS KRAS CALML4 CALML4 LOC111176690 LOC111176690 GRIN2B GRIN2B GNB5 GNB5 BRAF BRAF CALM1 CALM1 LOC111177332 LOC111177332 PRKACB PRKACB SLC6A3 SLC6A3 GRIN1 GRIN1 CREB3L2 CREB3L2 LOC111179105 LOC111179105 MAP2K1 MAP2K1 GRIN2D GRIN2D BDNF BDNF SLC29A1 SLC29A1 GNG5 GNG5 GNG12 GNG12 GNG11 GNG11 FOSB FOSB HDAC9 HDAC9 CREB5 CREB5 NRAS NRAS GNAI3 GNAI3 MAPK3 MAPK3 GNB2 GNB2 GNG8 GNG8 LOC111182462 LOC111182462 GNGT1 GNGT1 LOC111183465 LOC111183465 GRIN2C GRIN2C PPP1CA PPP1CA GRB2 GRB2 SHC4 SHC4 NPY NPY PDYN PDYN LOC111184525 LOC111184525 CREB3L1 CREB3L1 LOC111182816 LOC111182816 TH TH HDAC3 HDAC3 SLC29A3 SLC29A3 GNG13 GNG13 DRD1 DRD1 SLC29A2 SLC29A2 GNG3 GNG3 ATF4 ATF4 DDC DDC CAMKK1 CAMKK1 HDAC10 HDAC10 CAMKK2 CAMKK2 PPP1CC PPP1CC CALML6 CALML6 GNAS GNAS GRIN3A GRIN3A GNB1 GNB1 CREB3 CREB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1464 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC111164170Histone H3.3-like. (182 aa)
LOC111164829Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (473 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform X1. (354 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B isoform X1. (203 aa)
GNG14LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (101 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
MAOAAmine oxidase. (527 aa)
LOC111164824Histone deacetylase 2-like isoform X1. (260 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
MAOBAmine oxidase. (524 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
SHC3SHC-transforming protein 3. (588 aa)
LOC111168444Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111168449Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168519Histone H2A; Belongs to the histone H2A family. (131 aa)
LOC111168524Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168528Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168549Histone H2B; Belongs to the histone H2B family. (127 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
LOC111168445Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168515Histone H3; Belongs to the histone H3 family. (136 aa)
LOC111168520Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111168525Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168529Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168512Histone H2A; Belongs to the histone H2A family. (153 aa)
LOC111168516Histone H3; Belongs to the histone H3 family. (136 aa)
LOC111168521Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111168526Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168530Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC6Histone deacetylase 6 isoform X1. (1149 aa)
SLC18A1Chromaffin granule amine transporter. (523 aa)
LOC111169737Histone H3; Belongs to the histone H3 family. (136 aa)
LOC111169749Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111167415Histone H2A; Belongs to the histone H2A family. (143 aa)
LOC111168446Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168460Histone H2B; Belongs to the histone H2B family. (127 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
LOC111168517Histone H2A; Belongs to the histone H2A family. (134 aa)
LOC111168527Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168531Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (112 aa)
LOC111168543Uncharacterized protein LOC111168543; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (333 aa)
HRASGTPase HRas isoform X1. (189 aa)
LOC111167944Histone H3.3-like. (136 aa)
LOC111169314Histone H2A; Belongs to the histone H2A family. (130 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
LOC111168443Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111168448Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111169704Histone H3.3-like. (136 aa)
LOC111168514Histone H2A; Belongs to the histone H2A family. (139 aa)
LOC111168523Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168544Histone H2B type 1-L-like; Belongs to the histone H2B family. (143 aa)
LOC111168550Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC111169747Histone H2A; Belongs to the histone H2A family. (130 aa)
HDAC11Histone deacetylase 11. (347 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC111171120Late histone H2B.L4-like; Belongs to the histone H2B family. (135 aa)
LOC111171154Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC111169315Histone H2B; Belongs to the histone H2B family. (126 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
SLC18A2Synaptic vesicular amine transporter isoform X1. (517 aa)
GRIN3BGlutamate receptor ionotropic, NMDA 3B isoform X5; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1034 aa)
LOC111169736Histone H2B; Belongs to the histone H2B family. (197 aa)
LOC111169748Histone H2A; Belongs to the histone H2A family. (129 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC111171155Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC8Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (424 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1049 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
LOC111176743Histone H2B; Belongs to the histone H2B family. (122 aa)
LOC111176794Histone H2A; Belongs to the histone H2A family. (129 aa)
KRASGTPase KRas. (188 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
LOC111176690Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1499 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (414 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
LOC111177332Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (959 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
LOC111179105Histone H2A; Belongs to the histone H2A family. (128 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GRIN2DLOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D. (1334 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
SLC29A1Equilibrative nucleoside transporter 1 isoform X1. (465 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
FOSBProtein fosB isoform X1. (341 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1043 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
NRASGTPase NRas. (189 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
LOC111182462Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
LOC111183465Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C isoform X1. (1265 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
NPYPro-neuropeptide Y. (97 aa)
PDYNproenkephalin-B. (252 aa)
LOC111184525Histone H2A; Belongs to the histone H2A family. (128 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
LOC111182816Histone H3; Belongs to the histone H3 family. (136 aa)
THTyrosine 3-monooxygenase. (492 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
SLC29A3Equilibrative nucleoside transporter 3 isoform X2. (496 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
SLC29A2Equilibrative nucleoside transporter 2 isoform X1. (480 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
DDCaromatic-L-amino-acid decarboxylase isoform X1. (487 aa)
CAMKK1Calcium/calmodulin-dependent protein kinase kinase 1 isoform X1. (554 aa)
HDAC10Histone deacetylase 10 isoform X1. (677 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (580 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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