STRINGSTRING
CRKL CRKL CDC42 CDC42 CLTC CLTC WASF1 WASF1 WASF2 WASF2 DNM2 DNM2 CTNNA2 CTNNA2 PIK3R2 PIK3R2 SHC1 SHC1 DNM3 DNM3 CBL CBL SHC3 SHC3 CTNNB1 CTNNB1 LOC111167795 LOC111167795 HCLS1 HCLS1 ARPC4 ARPC4 ACTB ACTB SEPT6 SEPT6 ILK ILK LOC111170545 LOC111170545 CAV3 CAV3 ELMO2 ELMO2 DOCK1 DOCK1 SEPT2 SEPT2 SHC2 SHC2 ARPC2 ARPC2 PIK3CA PIK3CA FN1 FN1 PIK3R3 PIK3R3 RHOA RHOA DNM1 DNM1 CD2AP CD2AP LOC111178986 LOC111178986 ARHGEF26 ARHGEF26 MET MET ARPC5L ARPC5L BCAR1 BCAR1 WASL WASL ITGB1 ITGB1 PIK3CB PIK3CB CAV1 CAV1 CAV2 CAV2 ELMO1 ELMO1 CDH1 CDH1 ELMO3 ELMO3 SEPT1 SEPT1 ARPC1A ARPC1A CTNNA1 CTNNA1 SEPT8 SEPT8 SEPT9 SEPT9 ACTG1 ACTG1 SHC4 SHC4 CTNNA3 CTNNA3 RAC1 RAC1 ARPC1B ARPC1B SRC SRC CRK CRK SEPT12 SEPT12 ARPC5 ARPC5 SEPT3 SEPT3 ARPC3 ARPC3 PIK3R1 PIK3R1 MAD2L2 MAD2L2 CLTA CLTA GAB1 GAB1 ARHGAP10 ARHGAP10 PIK3CD PIK3CD SEPT11 SEPT11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCrk-like protein. (303 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (559 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
CTNNA2Catenin alpha-2. (865 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
DNM3Dynamin-3 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (873 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
SHC3SHC-transforming protein 3. (588 aa)
CTNNB1Catenin beta-1. (781 aa)
LOC111167795Rho-related GTP-binding protein RhoG-like isoform X1. (230 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
ACTBActin, cytoplasmic 1. (375 aa)
SEPT6Septin-6 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (593 aa)
ILKIntegrin-linked protein kinase. (452 aa)
LOC111170545Rho-related GTP-binding protein RhoG. (191 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (720 aa)
DOCK1Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1886 aa)
SEPT2Septin-2 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (361 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FN1Fibronectin isoform X5. (2478 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
RHOATransforming protein RhoA. (193 aa)
DNM1Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
CD2APCD2-associated protein isoform X1. (680 aa)
LOC111178986LOW QUALITY PROTEIN: catenin alpha-1-like. (908 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (870 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (727 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
ELMO3Engulfment and cell motility protein 3 isoform X1. (782 aa)
SEPT1Septin-1 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (367 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
CTNNA1Catenin alpha-1. (906 aa)
SEPT8Septin-8 isoform X8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (524 aa)
SEPT9Septin-9 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (578 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
SHC4SHC-transforming protein 4. (630 aa)
CTNNA3Catenin alpha-3. (944 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B isoform X1. (425 aa)
SRCTyrosine-protein kinase. (562 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
SEPT12Septin-12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (363 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
SEPT3Neuronal-specific septin-3 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (358 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (243 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
ARHGAP10Rho GTPase-activating protein 10 isoform X1. (786 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
SEPT11Septin-11 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (429 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.