STRINGSTRING
C1QA C1QA MAPK1 MAPK1 C1QC C1QC MYD88 MYD88 TIRAP TIRAP C1QB C1QB GNAI1 GNAI1 NLRP3 NLRP3 TICAM1 TICAM1 C3 C3 CASP1 CASP1 MAPK10 MAPK10 IRAK1 IRAK1 IL12B IL12B LOC111170700 LOC111170700 MAPK9 MAPK9 MAPK8 MAPK8 C2 C2 CASP3 CASP3 GNAI2 GNAI2 IRAK4 IRAK4 CFL2 CFL2 CASP7 CASP7 JUN JUN RHOA RHOA C1S C1S FOS FOS IL12A IL12A C1R C1R CALML4 CALML4 TLR4 TLR4 C5 C5 MAPK14 MAPK14 CALM1 CALM1 MAPK13 MAPK13 IRF8 IRF8 ITGB1 ITGB1 IRF3 IRF3 NOD1 NOD1 NFKB1 NFKB1 TRAF6 TRAF6 PYCARD PYCARD GNAI3 GNAI3 IRF1 IRF1 MAPK3 MAPK3 ITGAM ITGAM LOC111183594 LOC111183594 CFL1 CFL1 CD14 CD14 RELA RELA SERPING1 SERPING1 TICAM2 TICAM2 C4BPA C4BPA IL10 IL10 C4BPB C4BPB LY96 LY96 LOC111185989 LOC111185989 MAPK12 MAPK12 IL1A IL1A CALML6 CALML6 MAPK11 MAPK11 ITGB2 ITGB2 CXCL8 CXCL8 LOC111187648 LOC111187648 TNF TNF IL1B IL1B IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C1QAComplement C1q subcomponent subunit A. (245 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (226 aa)
C1QBComplement C1q subcomponent subunit B. (290 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1035 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (707 aa)
C3Complement C3 isoform X1. (1695 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (404 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
LOC111170700Complement C4-like isoform X1. (1740 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
C2Complement C2 isoform X1; Belongs to the peptidase S1 family. (751 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
C1SComplement C1s subcomponent; Belongs to the peptidase S1 family. (695 aa)
FOSProto-oncogene c-Fos. (380 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
C1RComplement C1r subcomponent isoform X1; Belongs to the peptidase S1 family. (713 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
C5Complement C5 isoform X1. (1677 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
IRF8Interferon regulatory factor 8 isoform X1. (427 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
IRF3Interferon regulatory factor 3 isoform X1. (464 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
IRF1Interferon regulatory factor. (322 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (872 aa)
LOC111183594Pulmonary surfactant-associated protein A. (283 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
RELATranscription factor p65 isoform X1. (562 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (471 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
C4BPAC4b-binding protein alpha chain isoform X1. (616 aa)
IL10Interleukin-10. (178 aa)
C4BPBC4b-binding protein beta chain isoform X1. (255 aa)
LY96Lymphocyte antigen 96. (160 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
ITGB2Integrin beta. (769 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
LOC111187648C-X-C motif chemokine 6-like. (113 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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