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| | GIT2 | ARF GTPase-activating protein GIT2 isoform X1. (759 aa) |
| | CRKL | Crk-like protein. (303 aa) |
| | CDC42 | Cell division control protein 42 homolog isoform X2. (191 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (380 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (783 aa) |
| | PKN2 | Serine/threonine-protein kinase N2 isoform X1. (983 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa) |
| | WASF2 | wiskott-Aldrich syndrome protein family member 2. (498 aa) |
| | ROCK2 | Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa) |
| | VAV1 | Proto-oncogene vav isoform X1. (845 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa) |
| | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa) |
| | PKN1 | Serine/threonine-protein kinase N1 isoform X1. (950 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa) |
| | NLRP3 | NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1035 aa) |
| | TICAM1 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (707 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | CASP1 | Caspase-1; Belongs to the peptidase C14A family. (404 aa) |
| | CD8A | T-cell surface glycoprotein CD8 alpha chain isoform X1. (239 aa) |
| | CD8B | T-cell surface glycoprotein CD8 beta chain. (210 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | WIPF2 | WAS/WASL-interacting protein family member 2 isoform X1. (440 aa) |
| | WAS | wiskott-Aldrich syndrome protein. (502 aa) |
| | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | LOC111167795 | Rho-related GTP-binding protein RhoG-like isoform X1. (230 aa) |
| | PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa) |
| | GSK3B | Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa) |
| | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12 isoform X1. (1544 aa) |
| | ACTB | Actin, cytoplasmic 1. (375 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (780 aa) |
| | IRAK1 | Interleukin-1 receptor-associated kinase 1. (725 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | LOC111170545 | Rho-related GTP-binding protein RhoG. (191 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ELMO2 | Engulfment and cell motility protein 2 isoform X1. (720 aa) |
| | DOCK1 | Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1886 aa) |
| | ITGA4 | Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa) |
| | IKBKG | NF-kappa-B essential modulator isoform X1. (412 aa) |
| | WIPF1 | WAS/WASL-interacting protein family member 1 isoform X1. (494 aa) |
| | ARF6 | ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa) |
| | FN1 | Fibronectin isoform X5. (2478 aa) |
| | IFNB1 | Interferon beta. (185 aa) |
| | PIP5K1B | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa) |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa) |
| | NLRC4 | NLR family CARD domain-containing protein 4 isoform X1. (1024 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (314 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (343 aa) |
| | RHOA | Transforming protein RhoA. (193 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | ARHGEF7 | Rho guanine nucleotide exchange factor 7 isoform X1. (862 aa) |
| | VAV2 | Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa) |
| | FOS | Proto-oncogene c-Fos. (380 aa) |
| | ACTR3B | Actin-related protein 3B isoform X1; Belongs to the actin family. (556 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (541 aa) |
| | TLR4 | Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | LCK | Tyrosine-protein kinase. (509 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | BCAR1 | Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa) |
| | WASL | Neural Wiskott-Aldrich syndrome protein isoform X1. (510 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (798 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | RPS6KA6 | Ribosomal protein S6 kinase. (745 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | SKAP2 | Src kinase-associated phosphoprotein 2. (359 aa) |
| | IRF3 | Interferon regulatory factor 3 isoform X1. (464 aa) |
| | VAV3 | Guanine nucleotide exchange factor VAV3. (954 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa) |
| | ELMO1 | Engulfment and cell motility protein 1 isoform X1. (727 aa) |
| | WIPF3 | WAS/WASL-interacting protein family member 3. (465 aa) |
| | NFATC3 | Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa) |
| | LIMK1 | LIM domain kinase 1 isoform X1. (647 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD. (195 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1 isoform X1. (998 aa) |
| | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa) |
| | ACTG1 | Actin, cytoplasmic 2. (375 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (192 aa) |
| | ACTR3 | Actin-related protein 3; Belongs to the actin family. (418 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | LAT | Linker for activation of T-cells family member 1 isoform X1. (270 aa) |
| | BAIAP2 | Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2. (522 aa) |
| | RELA | Transcription factor p65 isoform X1. (562 aa) |
| | SRC | Tyrosine-protein kinase. (562 aa) |
| | IL10 | Interleukin-10. (178 aa) |
| | CRK | Adapter molecule crk isoform X1. (304 aa) |
| | MEFV | Pyrin isoform X1. (756 aa) |
| | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa) |
| | ARHGEF28 | Rho guanine nucleotide exchange factor 28 isoform X1. (1759 aa) |
| | LOC111185731 | C-C motif chemokine. (99 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (456 aa) |
| | PTK2B | Protein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa) |
| | LCP2 | Lymphocyte cytosolic protein 2 isoform X1. (534 aa) |
| | LOC111187417 | Tyrosine-protein kinase. (612 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa) |
| | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa) |
