STRINGSTRING
GIT2 GIT2 CRKL CRKL CDC42 CDC42 MAPK1 MAPK1 RPS6KA1 RPS6KA1 PKN2 PKN2 MAP3K7 MAP3K7 MYD88 MYD88 WASF2 WASF2 ROCK2 ROCK2 VAV1 VAV1 MAP2K2 MAP2K2 MAP2K7 MAP2K7 PKN1 PKN1 PIK3R2 PIK3R2 TAB2 TAB2 NLRP3 NLRP3 TICAM1 TICAM1 IL18 IL18 CASP1 CASP1 CD8A CD8A CD8B CD8B RPS6KA3 RPS6KA3 PIP5K1C PIP5K1C MAPK10 MAPK10 WIPF2 WIPF2 WAS WAS MAP2K3 MAP2K3 LOC111167795 LOC111167795 PIP5K1A PIP5K1A GSK3B GSK3B NFATC1 NFATC1 ARHGEF12 ARHGEF12 ACTB ACTB RPS6KA2 RPS6KA2 IRAK1 IRAK1 MAPK9 MAPK9 LOC111170545 LOC111170545 MAPK8 MAPK8 ELMO2 ELMO2 DOCK1 DOCK1 ITGA4 ITGA4 IKBKG IKBKG WIPF1 WIPF1 ARF6 ARF6 PIK3CA PIK3CA CHUK CHUK IKBKB IKBKB FN1 FN1 IFNB1 IFNB1 PIP5K1B PIP5K1B IRAK4 IRAK4 NLRC4 NLRC4 PIK3R3 PIK3R3 NFKBIA NFKBIA JUN JUN RHOA RHOA AKT1 AKT1 TBK1 TBK1 ARHGEF7 ARHGEF7 VAV2 VAV2 FOS FOS ACTR3B ACTR3B GNAQ GNAQ AKT3 AKT3 TLR4 TLR4 TRAF2 TRAF2 LCK LCK MAPK14 MAPK14 MAPK13 MAPK13 BCAR1 BCAR1 WASL WASL ITGB1 ITGB1 PIK3CB PIK3CB RPS6KA6 RPS6KA6 MAP2K1 MAP2K1 SKAP2 SKAP2 IRF3 IRF3 VAV3 VAV3 NFKB1 NFKB1 ELMO1 ELMO1 WIPF3 WIPF3 NFATC3 NFATC3 LIMK1 LIMK1 TRAF6 TRAF6 PYCARD PYCARD ROCK1 ROCK1 RAC3 RAC3 AKT2 AKT2 MAPK3 MAPK3 ARHGEF1 ARHGEF1 MAP2K6 MAP2K6 ACTG1 ACTG1 RAC1 RAC1 ACTR3 ACTR3 PLCG1 PLCG1 LAT LAT BAIAP2 BAIAP2 RELA RELA SRC SRC IL10 IL10 CRK CRK MEFV MEFV MAP2K4 MAP2K4 RAC2 RAC2 ARHGEF28 ARHGEF28 LOC111185731 LOC111185731 TAB1 TAB1 MAPK12 MAPK12 PTK2B PTK2B ACTR2 ACTR2 LCP2 LCP2 LOC111187417 LOC111187417 PIK3R1 PIK3R1 MAPK11 MAPK11 CXCL8 CXCL8 NFATC2 NFATC2 PIK3CD PIK3CD TNF TNF IL1B IL1B CD4 CD4 IL6 IL6 IL2 IL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GIT2ARF GTPase-activating protein GIT2 isoform X1. (759 aa)
CRKLCrk-like protein. (303 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
RPS6KA1Ribosomal protein S6 kinase. (783 aa)
PKN2Serine/threonine-protein kinase N2 isoform X1. (983 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
ROCK2Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa)
VAV1Proto-oncogene vav isoform X1. (845 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa)
PKN1Serine/threonine-protein kinase N1 isoform X1. (950 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1035 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (707 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (404 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain isoform X1. (239 aa)
CD8BT-cell surface glycoprotein CD8 beta chain. (210 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
WIPF2WAS/WASL-interacting protein family member 2 isoform X1. (440 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC111167795Rho-related GTP-binding protein RhoG-like isoform X1. (230 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1544 aa)
ACTBActin, cytoplasmic 1. (375 aa)
RPS6KA2Ribosomal protein S6 kinase. (780 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC111170545Rho-related GTP-binding protein RhoG. (191 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (720 aa)
DOCK1Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1886 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
WIPF1WAS/WASL-interacting protein family member 1 isoform X1. (494 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
FN1Fibronectin isoform X5. (2478 aa)
IFNB1Interferon beta. (185 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
NLRC4NLR family CARD domain-containing protein 4 isoform X1. (1024 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (862 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
FOSProto-oncogene c-Fos. (380 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (556 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
LCKTyrosine-protein kinase. (509 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (510 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SKAP2Src kinase-associated phosphoprotein 2. (359 aa)
IRF3Interferon regulatory factor 3 isoform X1. (464 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (727 aa)
WIPF3WAS/WASL-interacting protein family member 3. (465 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
LIMK1LIM domain kinase 1 isoform X1. (647 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1 isoform X1. (998 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LATLinker for activation of T-cells family member 1 isoform X1. (270 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2. (522 aa)
RELATranscription factor p65 isoform X1. (562 aa)
SRCTyrosine-protein kinase. (562 aa)
IL10Interleukin-10. (178 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
MEFVPyrin isoform X1. (756 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28 isoform X1. (1759 aa)
LOC111185731C-C motif chemokine. (99 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
LCP2Lymphocyte cytosolic protein 2 isoform X1. (534 aa)
LOC111187417Tyrosine-protein kinase. (612 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (154 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: medium (44%) [HD]