STRINGSTRING
MAPK1 MAPK1 IFNGR2 IFNGR2 MAP3K7 MAP3K7 MYD88 MYD88 ELK1 ELK1 IFNGR1 IFNGR1 TAB2 TAB2 C3 C3 IRAK1 IRAK1 IL12B IL12B ITGA4 ITGA4 STAT1 STAT1 LOC111170413 LOC111170413 LOC111170450 LOC111170450 JAK2 JAK2 IRAK4 IRAK4 NFKBIA NFKBIA JUN JUN IFNG IFNG FOS FOS MARCKSL1 MARCKSL1 IL12A IL12A PTPN6 PTPN6 TLR4 TLR4 TGFB2 TGFB2 LOC111178664 LOC111178664 MAPK14 MAPK14 LOC111178928 LOC111178928 LOC111178931 LOC111178931 TGFB3 TGFB3 LOC111178043 LOC111178043 LOC111178668 LOC111178668 MAPK13 MAPK13 LOC111179403 LOC111179403 LOC111178925 LOC111178925 LOC111178929 LOC111178929 ITGB1 ITGB1 LOC111178666 LOC111178666 NFKBIB NFKBIB JAK1 JAK1 NFKB1 NFKB1 LOC111179231 LOC111179231 TGFB1 TGFB1 LOC111178927 LOC111178927 NCF1 NCF1 TRAF6 TRAF6 MAPK3 MAPK3 ITGAM ITGAM PRKCB PRKCB EEF1A1 EEF1A1 IL4 IL4 RELA RELA NCF2 NCF2 CR1 CR1 IL10 IL10 PTGS2 PTGS2 TAB1 TAB1 LOC111185989 LOC111185989 EEF1A2 EEF1A2 MAPK12 MAPK12 IL1A IL1A MAPK11 MAPK11 LOC111186386 LOC111186386 ITGB2 ITGB2 LOC111187847 LOC111187847 TLR2 TLR2 TNF TNF IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
IFNGR2Interferon gamma receptor 2. (364 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ELK1LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1. (442 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
C3Complement C3 isoform X1. (1695 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
LOC111170413Low affinity immunoglobulin gamma Fc region receptor III-like isoform X1. (278 aa)
LOC111170450Cytochrome b-245 heavy chain isoform X1. (570 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
FOSProto-oncogene c-Fos. (380 aa)
MARCKSL1MARCKS-related protein. (198 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LOC111178664HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC111178928DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC111178931HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
LOC111178043LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like. (404 aa)
LOC111178668HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LOC111179403Cytochrome b-245 light chain isoform X1. (202 aa)
LOC111178925boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X2. (276 aa)
LOC111178929HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1. (231 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
LOC111178666HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
LOC111179231Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (421 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
LOC111178927HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family. (255 aa)
NCF1Neutrophil cytosol factor 1 isoform X2. (405 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (872 aa)
PRKCBProtein kinase C. (689 aa)
EEF1A1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
RELATranscription factor p65 isoform X1. (562 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
CR1Complement receptor type 1 isoform X1. (1062 aa)
IL10Interleukin-10. (178 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
MAPK12Mitogen-activated protein kinase. (456 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
MAPK11Mitogen-activated protein kinase. (366 aa)
LOC111186386Neutrophil cytosol factor 4-like. (250 aa)
ITGB2Integrin beta. (769 aa)
LOC111187847Neutrophil cytosol factor 4 isoform X2. (339 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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