STRINGSTRING
LAMA1 LAMA1 GNAL GNAL LAMA4 LAMA4 PLCB1 PLCB1 PLCB4 PLCB4 COL4A5 COL4A5 RAB5C RAB5C GNA11 GNA11 PIK3R2 PIK3R2 RAB5A RAB5A ARG1 ARG1 COL4A6 COL4A6 PRKACA PRKACA GNA15 GNA15 LOC111167107 LOC111167107 COL1A1 COL1A1 LAMA2 LAMA2 RAB7A RAB7A IL12B IL12B COL4A4 COL4A4 COL4A3 COL4A3 COL3A1 COL3A1 ACTN1 ACTN1 LOC111171097 LOC111171097 PIK3CA PIK3CA CASP3 CASP3 FN1 FN1 ARG2 ARG2 GNA14 GNA14 RAB5B RAB5B C8B C8B PIK3R3 PIK3R3 C8A C8A IFNG IFNG PRDX1 PRDX1 COL4A2 COL4A2 LAMB2 LAMB2 IL12A IL12A GNAQ GNAQ TLR4 TLR4 TGFB2 TGFB2 COL4A1 COL4A1 LAMC3 LAMC3 TGFB3 TGFB3 PRKACB PRKACB C8G C8G PIK3CB PIK3CB LOC111180193 LOC111180193 NFKB1 NFKB1 TGFB1 TGFB1 ACTN4 ACTN4 LAMA3 LAMA3 LOC111181303 LOC111181303 PLCB2 PLCB2 HSPB1 HSPB1 ITGAM ITGAM PRKCB PRKCB CSF2 CSF2 COL1A2 COL1A2 PRKCA PRKCA PLCB3 PLCB3 CD14 CD14 RELA RELA LAMC2 LAMC2 ADCY1 ADCY1 LAMB1 LAMB1 LAMB4 LAMB4 IL10 IL10 RAB7B RAB7B LAMB3 LAMB3 LAMC1 LAMC1 LOC111185989 LOC111185989 LAMA5 LAMA5 LOC111187662 LOC111187662 PIK3R1 PIK3R1 C9 C9 ITGB2 ITGB2 LOC111187576 LOC111187576 CXCL8 CXCL8 GNAS GNAS PIK3CD PIK3CD IL1R1 IL1R1 IL1R2 IL1R2 LOC111187591 LOC111187591 TLR2 TLR2 TNF TNF IL1B IL1B IL6 IL6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMA1Laminin subunit alpha-1 isoform X1. (3081 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha isoform X2. (380 aa)
LAMA4Laminin subunit alpha-4 isoform X1. (1824 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
COL4A5Collagen alpha-5(IV) chain. (1685 aa)
RAB5CRas-related protein Rab-5C. (216 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
ARG1Arginase. (322 aa)
COL4A6Collagen alpha-6(IV) chain. (1706 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15 isoform X1. (374 aa)
LOC111167107T-cell surface glycoprotein CD1b-2-like. (333 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
LAMA2Laminin subunit alpha-2. (3008 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
COL4A4Collagen alpha-4(IV) chain. (1686 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
ACTN1Alpha-actinin-1 isoform X2. (914 aa)
LOC111171097Cathepsin G-like isoform X1; Belongs to the peptidase S1 family. (307 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
FN1Fibronectin isoform X5. (2478 aa)
ARG2Arginase. (354 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
RAB5BRas-related protein Rab-5B. (215 aa)
C8BComplement component C8 beta chain isoform X1. (590 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
C8AComplement component C8 alpha chain isoform X1. (589 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PRDX1Peroxiredoxin-1. (199 aa)
COL4A2Collagen alpha-2(IV) chain isoform X1. (1760 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1812 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
COL4A1Collagen alpha-1(IV) chain isoform X1. (1668 aa)
LAMC3Laminin subunit gamma-3. (1577 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
C8GComplement component C8 gamma chain isoform X1; Belongs to the calycin superfamily. Lipocalin family. (339 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LOC111180193Serpin B10; Belongs to the serpin family. (398 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ACTN4Alpha-actinin-4 isoform X5. (933 aa)
LAMA3Laminin subunit alpha-3 isoform X3. (3335 aa)
LOC111181303Serpin B6-like isoform X1; Belongs to the serpin family. (399 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (872 aa)
PRKCBProtein kinase C. (689 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
RELATranscription factor p65 isoform X1. (562 aa)
LAMC2Laminin subunit gamma-2. (1191 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
LAMB4LOW QUALITY PROTEIN: laminin subunit beta-4. (1767 aa)
IL10Interleukin-10. (178 aa)
RAB7BRas-related protein Rab-7b isoform X1. (210 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
LAMA5Laminin subunit alpha-5. (3687 aa)
LOC111187662C-X-C motif chemokine. (104 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
C9Complement component C9. (548 aa)
ITGB2Integrin beta. (769 aa)
LOC111187576C-X-C motif chemokine. (104 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (686 aa)
IL1R2Interleukin-1 receptor type 2. (421 aa)
LOC111187591C-X-C motif chemokine. (104 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.