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| | GNGT2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa) |
| | CRKL | Crk-like protein. (303 aa) |
| | LOC111163175 | Cyclin-dependent kinase inhibitor 2A-like. (152 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (380 aa) |
| | LOC111163731 | C-C motif chemokine. (93 aa) |
| | E2F2 | Transcription factor E2F2 isoform X1. (437 aa) |
| | GNG4 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | LOC111163732 | C-C motif chemokine. (92 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | ADCY4 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | ADCY8 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa) |
| | ADCY7 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa) |
| | CCL5 | C-C motif chemokine. (91 aa) |
| | LOC111163733 | C-C motif chemokine. (90 aa) |
| | IL10RB | Interleukin-10 receptor subunit beta isoform X1. (361 aa) |
| | LOC111163130 | Interferon alpha-1-like. (226 aa) |
| | NFATC4 | LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa) |
| | CX3CL1 | Fractalkine. (469 aa) |
| | ROCK2 | Rho-associated protein kinase 2 isoform X2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1416 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa) |
| | ELK1 | LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1. (442 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa) |
| | GNA11 | Guanine nucleotide-binding protein subunit alpha-11. (359 aa) |
| | GNAO1 | Guanine nucleotide-binding protein G(O) subunit alpha isoform X1. (354 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | LOC111166690 | H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1; Belongs to the MHC class I family. (559 aa) |
| | GNG14 | LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (101 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa) |
| | ARHGEF11 | Rho guanine nucleotide exchange factor 11 isoform X1. (1576 aa) |
| | CREB3L4 | Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa) |
| | CREB3L3 | Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa) |
| | PTGER1 | Prostaglandin E2 receptor EP1 subtype. (405 aa) |
| | CALR | Calreticulin. (417 aa) |
| | AKAP13 | A-kinase anchor protein 13 isoform X5. (1430 aa) |
| | CTNNB1 | Catenin beta-1. (781 aa) |
| | IL10RA | Interleukin-10 receptor subunit alpha isoform X1. (579 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | IL6R | Interleukin-6 receptor subunit alpha isoform X1. (465 aa) |
| | GSK3B | Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa) |
| | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12 isoform X1. (1544 aa) |
| | HRAS | GTPase HRas isoform X1. (189 aa) |
| | ATF6B | LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa) |
| | LOC111171351 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (113 aa) |
| | LOC111170644 | BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1; Belongs to the MHC class I family. (360 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (522 aa) |
| | ITGAV | Integrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa) |
| | ADCY5 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa) |
| | GNA12 | Guanine nucleotide-binding protein subunit alpha-12 isoform X2. (279 aa) |
| | CASP8 | Caspase-8; Belongs to the peptidase C14A family. (486 aa) |
| | CXCL12 | Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa) |
| | GNG7 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | IKBKG | NF-kappa-B essential modulator isoform X1. (412 aa) |
| | LOC111171121 | Interferon alpha-1-like. (133 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | LOC111171122 | Interferon alpha-1-like isoform X1. (195 aa) |
| | SOS2 | Son of sevenless homolog 2 isoform X1. (1332 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa) |
| | CASP3 | Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | CXCR2 | C-X-C chemokine receptor type 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | GNB4 | Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa) |
| | CCR3 | C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa) |
| | CCR1 | C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa) |
| | IFNB1 | Interferon beta. (185 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa) |
| | SP1 | Transcription factor Sp1. (786 aa) |
| | LOC111174575 | Cytochrome c-like. (69 aa) |
| | ADCY3 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa) |
| | SOS1 | Son of sevenless homolog 1 isoform X1. (1333 aa) |
| | LOC111174480 | C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa) |
| | LOC111172911 | Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | PTGER2 | Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (354 aa) |
| | GNG2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (314 aa) |
| | RHOA | Transforming protein RhoA. (193 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | RHEB | GTP-binding protein Rheb. (184 aa) |
| | KRAS | GTPase KRas. (188 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa) |
| | LOC111174031 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | ADCY6 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa) |
| | LOC111174197 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (541 aa) |
| | LOC111175930 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CALML4 | Calmodulin-like protein 4 isoform X1. (189 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | TSC1 | Hamartin. (1169 aa) |
| | LOC111176690 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa) |
| | LOC111178659 | Antigen peptide transporter 2-like isoform X4. (758 aa) |
| | BAK1 | Bcl-2 homologous antagonist/killer isoform X1. (239 aa) |
| | GNB5 | Guanine nucleotide-binding protein subunit beta-5 isoform X1. (414 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | VEGFA | Vascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa) |
| | CALM1 | Calmodulin-1; Belongs to the calmodulin family. (149 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1. (164 aa) |
| | LOC111177332 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A. (445 aa) |
| | PRKACB | cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa) |
| | PTGER3 | Prostaglandin E2 receptor EP3 subtype. (389 aa) |
| | TAP1 | Antigen peptide transporter 1 isoform X1. (750 aa) |
| | TAPBP | Tapasin isoform X1. (451 aa) |
| | CREB3L2 | Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa) |
| | BCAR1 | Breast cancer anti-estrogen resistance protein 1 isoform X4. (867 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa) |
| | CDK6 | Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa) |
| | GNG5 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | IRF3 | Interferon regulatory factor 3 isoform X1. (464 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | JAK1 | Tyrosine-protein kinase. (1153 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa) |
| | ADCY2 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa) |
| | BAX | Apoptosis regulator BAX isoform X2. (223 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | NFATC3 | Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa) |
| | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | NRAS | GTPase NRas. (189 aa) |
| | LOC111180543 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (789 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa) |
| | GNG8 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa) |
| | GNA13 | Guanine nucleotide-binding protein subunit alpha-13. (377 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1 isoform X1. (998 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | PRKCB | Protein kinase C. (689 aa) |
| | MB21D1 | Cyclic GMP-AMP synthase. (513 aa) |
| | LOC111181647 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa) |
| | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa) |
| | E2F3 | LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (544 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | LOC111181648 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (192 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa) |
| | TMEM173 | Stimulator of interferon genes protein. (431 aa) |
| | RELA | Transcription factor p65 isoform X1. (562 aa) |
| | CREB3L1 | Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa) |
| | LOC111184277 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa) |
| | SRC | Tyrosine-protein kinase. (562 aa) |
| | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa) |
| | ADCY1 | Adenylate cyclase type 1. (907 aa) |
| | CRK | Adapter molecule crk isoform X1. (304 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | E2F1 | Transcription factor E2F1. (437 aa) |
| | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | LOC111185731 | C-C motif chemokine. (99 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2. (604 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa) |
| | TSC2 | Tuberin isoform X8. (1815 aa) |
| | ADCY9 | Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa) |
| | CASP9 | Caspase-9; Belongs to the peptidase C14A family. (452 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (456 aa) |
| | PTK2B | Protein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | CALML6 | Calmodulin-like protein 6 isoform X2. (227 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | PPP3R1 | Calcineurin subunit B type 1. (170 aa) |
| | CXCL8 | Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa) |
| | GNAS | Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa) |
| | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa) |
| | PPP3R2 | LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa) |
| | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa) |
| | PTGER4 | Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (486 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa) |
| | IL1R1 | Interleukin-1 receptor type 1 isoform X1. (686 aa) |
| | CREB3 | Cyclic AMP-responsive element-binding protein 3. (370 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa) |
