STRINGSTRING
LAMA1 LAMA1 NFX1 NFX1 CDC42 CDC42 WNT4 WNT4 MAPK1 MAPK1 IFNAR1 IFNAR1 IFNAR2 IFNAR2 UBR4 UBR4 OASL OASL IRF9 IRF9 RPS6KB1 RPS6KB1 RELN RELN ITGA9 ITGA9 LAMA4 LAMA4 RBL2 RBL2 LOC111164829 LOC111164829 ATP6V0D2 ATP6V0D2 LOC111163130 LOC111163130 HEY2 HEY2 LOC111163861 LOC111163861 TBPL1 TBPL1 MAP2K2 MAP2K2 TYK2 TYK2 HEY1 HEY1 COL4A5 COL4A5 ATP6V1A ATP6V1A ATP6V1C2 ATP6V1C2 LOC111166690 LOC111166690 COMP COMP TCF7L1 TCF7L1 ATP6V0A1 ATP6V0A1 PIK3R2 PIK3R2 CHAD CHAD LOC111164824 LOC111164824 COL4A6 COL4A6 PRKACA PRKACA ATP6V1H ATP6V1H THBS3 THBS3 TICAM1 TICAM1 CREB3L4 CREB3L4 CRB3 CRB3 LOC111166251 LOC111166251 ITGA3 ITGA3 PARD6G PARD6G JAG1 JAG1 TNN TNN TNR TNR THBS2 THBS2 LLGL1 LLGL1 COL6A6 COL6A6 ATM ATM PPP2R1B PPP2R1B ATP6V1B1 ATP6V1B1 CREB3L3 CREB3L3 WNT7A WNT7A TUBG2 TUBG2 COL1A1 COL1A1 NOTCH3 NOTCH3 CTNNB1 CTNNB1 WNT3A WNT3A LFNG LFNG GSK3B GSK3B LOC111168189 LOC111168189 LAMA2 LAMA2 PPP2R3B PPP2R3B FASLG FASLG ITGA2B ITGA2B HRAS HRAS BCAP31 BCAP31 TADA3 TADA3 ATP6V1B2 ATP6V1B2 DLG3 DLG3 LOC111170864 LOC111170864 TBP TBP NOTCH4 NOTCH4 ATP6V1G3 ATP6V1G3 MAML2 MAML2 LOC111170644 LOC111170644 FZD5 FZD5 COL4A4 COL4A4 ITGB5 ITGB5 RAF1 RAF1 COL4A3 COL4A3 WNT10A WNT10A COL6A3 COL6A3 FZD2 FZD2 MAML1 MAML1 WNT9A WNT9A ITGA4 ITGA4 ITGAV ITGAV STAT1 STAT1 HES6 HES6 PPP2R2D PPP2R2D CASP8 CASP8 DLG1 DLG1 FAS FAS IKBKG IKBKG LOC111171121 LOC111171121 PPP2R3C PPP2R3C CREB1 CREB1 ATP6V1D ATP6V1D PPP2CB PPP2CB EIF4EBP1 EIF4EBP1 ATP6V1G2 ATP6V1G2 CDK4 CDK4 STAT2 STAT2 MPP5 MPP5 ATP6AP1 ATP6AP1 LOC111171122 LOC111171122 TCF7L2 TCF7L2 SOS2 SOS2 PIK3CA PIK3CA CHUK CHUK CDK2 CDK2 CASP3 CASP3 TLR3 TLR3 ITGB7 ITGB7 HES1 HES1 FZD7 FZD7 IKBKB IKBKB FN1 FN1 ITGB6 ITGB6 IFNB1 IFNB1 PPP2R5E PPP2R5E WNT6 WNT6 COL2A1 COL2A1 PRKCI PRKCI WNT5A WNT5A SOS1 SOS1 FOXO1 FOXO1 PTEN PTEN HDAC1 HDAC1 ITGA7 ITGA7 ITGA6 ITGA6 WNT10B WNT10B HEYL HEYL EIF2AK2 EIF2AK2 PIK3R3 PIK3R3 PSMC1 PSMC1 DVL3 DVL3 AKT1 AKT1 CCNA1 CCNA1 TRAF3 TRAF3 MDM2 MDM2 TBK1 TBK1 CHD4 CHD4 RHEB RHEB COL4A2 COL4A2 KRAS KRAS WNT1 WNT1 CCND2 CCND2 MAGI1 MAGI1 LAMB2 LAMB2 COL9A2 COL9A2 ATP6V0B ATP6V0B WNT5B WNT5B AKT3 AKT3 PATJ PATJ ITGA11 ITGA11 PARD3 PARD3 COL4A1 COL4A1 TSC1 TSC1 LAMC3 LAMC3 ATP6V1E1 ATP6V1E1 FZD8 FZD8 ATP6V1F ATP6V1F BAK1 BAK1 ITGA8 ITGA8 CCND3 CCND3 VEGFA VEGFA IBSP IBSP PSEN1 PSEN1 CDKN1A CDKN1A ATP6V1G1 ATP6V1G1 VWF VWF TNFRSF1A TNFRSF1A PRKACB PRKACB CDKN1B CDKN1B NOTCH1 NOTCH1 ATP6V0E2 ATP6V0E2 PKM PKM ITGA10 ITGA10 PPP2R5D PPP2R5D CREB3L2 CREB3L2 TNC TNC ITGB1 ITGB1 PIK3CB PIK3CB ATP6V1C1 ATP6V1C1 MAP2K1 MAP2K1 TERT TERT CDK6 CDK6 WNT2B WNT2B IRF3 IRF3 SPP1 SPP1 JAK1 JAK1 NFKB1 NFKB1 MAML3 MAML3 FZD1 FZD1 WNT2 WNT2 ATR ATR FZD6 FZD6 CCNE2 CCNE2 LAMA3 LAMA3 CCNE1 CCNE1 BAX BAX ATP6V0D1 ATP6V0D1 TRADD TRADD WNT16 WNT16 PPP2R2C PPP2R2C PPP2R3A PPP2R3A PPP2R1A PPP2R1A PARD6A PARD6A CREB5 CREB5 NOTCH2 NOTCH2 NRAS NRAS FZD9 FZD9 IRF1 IRF1 TCF7 TCF7 ITGB3 ITGB3 RFNG RFNG AKT2 AKT2 MAPK3 MAPK3 SLC9A3R1 SLC9A3R1 WNT8A WNT8A WNT3 WNT3 CSNK1A1 CSNK1A1 COL1A2 COL1A2 PPP2CA PPP2CA ATP6V0A4 ATP6V0A4 LLGL2 LLGL2 RPS6KB2 RPS6KB2 GRB2 GRB2 AXIN2 AXIN2 PPP2R5B PPP2R5B ITGB8 ITGB8 THBS1 THBS1 PDGFRB PDGFRB FADD FADD CCND1 CCND1 APC APC RELA RELA LAMC2 LAMC2 CREB3L1 CREB3L1 PPP2R5A PPP2R5A PPP2R2B PPP2R2B RBL1 RBL1 WNT11 WNT11 THBS4 THBS4 RBPJL RBPJL COL9A1 COL9A1 LAMB1 LAMB1 LAMB4 LAMB4 TCIRG1 TCIRG1 LAMB3 LAMB3 DLG2 DLG2 BAD BAD FZD4 FZD4 AXIN1 AXIN1 E2F1 E2F1 FZD3 FZD3 CCNA2 CCNA2 CREBBP CREBBP ATP6V0E1 ATP6V0E1 EGFR EGFR PTGS2 PTGS2 LAMC1 LAMC1 IKBKE IKBKE MFNG MFNG ATP6V0C ATP6V0C TSC2 TSC2 COL6A2 COL6A2 COL6A1 COL6A1 PPP2R2A PPP2R2A WNT7B WNT7B EP300 EP300 HES5 HES5 DVL2 DVL2 VTN VTN PARD6B PARD6B LAMA5 LAMA5 ATP6V0A2 ATP6V0A2 FZD10 FZD10 HES7 HES7 PIK3R1 PIK3R1 DVL1 DVL1 HES4 HES4 HES2 HES2 HES3 HES3 MTOR MTOR PRKCZ PRKCZ COL9A3 COL9A3 GNAS GNAS ITGA2 ITGA2 ITGA1 ITGA1 PTGER4 PTGER4 PIK3CD PIK3CD UBE3A UBE3A CREB3 CREB3 TP53 TP53 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMA1Laminin subunit alpha-1 isoform X1. (3081 aa)
NFX1Transcriptional repressor NF-X1 isoform X1. (1118 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
IFNAR1Interferon alpha/beta receptor 1 isoform X1. (561 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (594 aa)
UBR4E3 ubiquitin-protein ligase UBR4 isoform X1. (5220 aa)
OASL2'-5'-oligoadenylate synthase-like protein isoform X1. (533 aa)
IRF9LOW QUALITY PROTEIN: interferon regulatory factor 9. (479 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RELNReelin isoform X1. (3460 aa)
ITGA9Integrin alpha-9; Belongs to the integrin alpha chain family. (1035 aa)
LAMA4Laminin subunit alpha-4 isoform X1. (1824 aa)
RBL2Retinoblastoma-like protein 2. (1083 aa)
LOC111164829Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (473 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
LOC111163130Interferon alpha-1-like. (226 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
LOC111163861LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx1-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (518 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1. (304 aa)
COL4A5Collagen alpha-5(IV) chain. (1685 aa)
ATP6V1ALOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A. (621 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
LOC111166690H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1; Belongs to the MHC class I family. (559 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (601 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
CHADChondroadherin. (359 aa)
LOC111164824Histone deacetylase 2-like isoform X1. (260 aa)
COL4A6Collagen alpha-6(IV) chain. (1706 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (480 aa)
THBS3Thrombospondin-3 isoform X4. (957 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (707 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
CRB3Protein crumbs homolog 3. (123 aa)
LOC111166251Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
ITGA3Integrin alpha-3 isoform X1; Belongs to the integrin alpha chain family. (1068 aa)
PARD6GPartitioning defective 6 homolog gamma. (371 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
TNNtenascin-N. (1296 aa)
TNRtenascin-R isoform X1. (1358 aa)
THBS2Thrombospondin-2. (1171 aa)
LLGL1Lethal(2) giant larvae protein homolog 1 isoform X1. (1063 aa)
COL6A6Collagen alpha-6(VI) chain isoform X1. (2268 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (601 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
TUBG2Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (451 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
NOTCH3Neurogenic locus notch homolog protein 3 isoform X1. (2336 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (378 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC111168189Collagen alpha-5(VI) chain-like. (1419 aa)
LAMA2Laminin subunit alpha-2. (3008 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (578 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (1034 aa)
HRASGTPase HRas isoform X1. (189 aa)
BCAP31B-cell receptor-associated protein 31. (245 aa)
TADA3Transcriptional adapter 3 isoform X1. (444 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (849 aa)
LOC111170864Recombining binding protein suppressor of hairless isoform X1. (500 aa)
TBPTATA-box-binding protein. (319 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (198 aa)
MAML2Mastermind-like protein 2. (1120 aa)
LOC111170644BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1; Belongs to the MHC class I family. (360 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
COL4A4Collagen alpha-4(IV) chain. (1686 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
COL6A3Collagen alpha-3(VI) chain isoform X1. (3229 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
MAML1Mastermind-like protein 1. (1018 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
HES6Transcription cofactor HES-6 isoform X1. (224 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
LOC111171121Interferon alpha-1-like. (133 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ATP6V1DV-type proton ATPase subunit D isoform X1. (247 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
STAT2Signal transducer and activator of transcription. (911 aa)
MPP5MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa)
ATP6AP1V-type proton ATPase subunit S1. (469 aa)
LOC111171122Interferon alpha-1-like isoform X1. (195 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (819 aa)
HES1Transcription factor HES-1. (280 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
FN1Fibronectin isoform X5. (2478 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (808 aa)
IFNB1Interferon beta. (185 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
FOXO1Forkhead box protein O1. (663 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
ITGA7Integrin alpha-7 isoform X1; Belongs to the integrin alpha chain family. (1141 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1091 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (357 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (539 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PSMC126S proteasome regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X3. (731 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1940 aa)
RHEBGTP-binding protein Rheb. (184 aa)
COL4A2Collagen alpha-2(IV) chain isoform X1. (1760 aa)
KRASGTPase KRas. (188 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
MAGI1Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1. (1484 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1812 aa)
COL9A2Collagen alpha-2(IX) chain isoform X1. (832 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family. (233 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
PATJinaD-like protein isoform X1. (1900 aa)
ITGA11Integrin alpha-11; Belongs to the integrin alpha chain family. (1188 aa)
PARD3Partitioning defective 3 homolog isoform X1. (1356 aa)
COL4A1Collagen alpha-1(IV) chain isoform X1. (1668 aa)
TSC1Hamartin. (1169 aa)
LAMC3Laminin subunit gamma-3. (1577 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (226 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
ITGA8Integrin alpha-8 isoform X1; Belongs to the integrin alpha chain family. (1062 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
IBSPBone sialoprotein 2. (317 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
VWFVon Willebrand factor. (2806 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
ATP6V0E2V-type proton ATPase subunit e 2. (112 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
ITGA10Integrin alpha-10; Belongs to the integrin alpha chain family. (1167 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
TNCTenascin isoform X1. (2201 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1203 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
IRF3Interferon regulatory factor 3 isoform X1. (464 aa)
SPP1Osteopontin. (362 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
MAML3Mastermind-like protein 3 isoform X1. (1099 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ATRSerine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. (2655 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
LAMA3Laminin subunit alpha-3 isoform X3. (3335 aa)
CCNE1G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1151 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
NRASGTPase NRas. (189 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
IRF1Interferon regulatory factor. (322 aa)
TCF7Transcription factor 7 isoform X1. (415 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
RFNGBeta-1,3-N-acetylglucosaminyltransferase. (336 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (398 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
CSNK1A1Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (380 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
LLGL2Lethal(2) giant larvae protein homolog 2 isoform X1. (1057 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AXIN2Axin-2 isoform X1. (843 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
THBS1Thrombospondin-1. (1170 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
APCAdenomatous polyposis coli protein isoform X1. (2864 aa)
RELATranscription factor p65 isoform X1. (562 aa)
LAMC2Laminin subunit gamma-2. (1191 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (545 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1073 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
THBS4Thrombospondin-4. (961 aa)
RBPJLRecombining binding protein suppressor of hairless-like protein. (516 aa)
COL9A1Collagen alpha-1(IX) chain isoform X1. (925 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
LAMB4LOW QUALITY PROTEIN: laminin subunit beta-4. (1767 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
BADBcl2-associated agonist of cell death. (168 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
AXIN1Axin-1 isoform X1. (866 aa)
E2F1Transcription factor E2F1. (437 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (807 aa)
MFNGbeta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1. (345 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
TSC2Tuberin isoform X8. (1815 aa)
COL6A2Collagen alpha-2(VI) chain isoform X1. (1027 aa)
COL6A1Collagen alpha-1(VI) chain. (1027 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
EP300Histone acetyltransferase p300. (2420 aa)
HES5Transcription factor HES-5 isoform X1. (205 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
VTNVitronectin. (565 aa)
PARD6BPartitioning defective 6 homolog beta. (372 aa)
LAMA5Laminin subunit alpha-5. (3687 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (867 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
HES7Transcription factor HES-7 isoform X2. (229 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
HES4Transcription factor HES-4 isoform X2. (225 aa)
HES2Transcription factor HES-2. (163 aa)
HES3Transcription factor HES-3. (178 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
COL9A3Collagen alpha-3(IX) chain. (684 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
ITGA1Integrin alpha-1; Belongs to the integrin alpha chain family. (1178 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (486 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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