Your Input: | |
| | GNGT2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa) |
| | LOC111162707 | LIM domain kinase 2 isoform X1. (837 aa) |
| | CRKL | Crk-like protein. (303 aa) |
| | CCNB1 | G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (433 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (380 aa) |
| | GNG4 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa) |
| | AP1G2 | AP-1 complex subunit gamma. (786 aa) |
| | AP1B1 | AP complex subunit beta. (949 aa) |
| | LOC111163130 | Interferon alpha-1-like. (226 aa) |
| | NFATC4 | LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa) |
| | WEE1 | Wee1-like protein kinase. (646 aa) |
| | PAK5 | Non-specific serine/threonine protein kinase. (719 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa) |
| | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (458 aa) |
| | AP1M2 | AP-1 complex subunit mu-2 isoform X1; Belongs to the adaptor complexes medium subunit family. (425 aa) |
| | GNA11 | Guanine nucleotide-binding protein subunit alpha-11. (359 aa) |
| | GNAO1 | Guanine nucleotide-binding protein G(O) subunit alpha isoform X1. (354 aa) |
| | LOC111166690 | H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1; Belongs to the MHC class I family. (559 aa) |
| | BST2 | Bone marrow stromal antigen 2. (160 aa) |
| | GNG14 | LOW QUALITY PROTEIN: uncharacterized LOC105372280 homolog. (101 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa) |
| | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa) |
| | CD3D | T-cell surface glycoprotein CD3 delta chain. (171 aa) |
| | CD3G | T-cell surface glycoprotein CD3 gamma chain. (178 aa) |
| | AP1M1 | AP-1 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (423 aa) |
| | CD3E | T-cell surface glycoprotein CD3 epsilon chain. (197 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | PAK3 | Non-specific serine/threonine protein kinase. (559 aa) |
| | CUL5 | Cullin-5 isoform X1; Belongs to the cullin family. (831 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | CUL4B | cullin-4B isoform X1; Belongs to the cullin family. (904 aa) |
| | CALR | Calreticulin. (417 aa) |
| | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (928 aa) |
| | CD247 | T-cell surface glycoprotein CD3 zeta chain isoform X1. (185 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1. (540 aa) |
| | HRAS | GTPase HRas isoform X1. (189 aa) |
| | IRAK1 | Interleukin-1 receptor-associated kinase 1. (725 aa) |
| | LOC111169208 | Wee1-like protein kinase. (443 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | LOC111171351 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (113 aa) |
| | LOC111170644 | BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1; Belongs to the MHC class I family. (360 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | AP1S2 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa) |
| | AP1S3 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (522 aa) |
| | CASP8 | Caspase-8; Belongs to the peptidase C14A family. (486 aa) |
| | CCNB3 | LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1456 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa) |
| | GNG7 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | IKBKG | NF-kappa-B essential modulator isoform X1. (412 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (523 aa) |
| | LOC111171121 | Interferon alpha-1-like. (133 aa) |
| | BTRC | F-box/WD repeat-containing protein 1A isoform X1. (607 aa) |
| | LOC111171122 | Interferon alpha-1-like isoform X1. (195 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa) |
| | CASP3 | Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | GNB4 | Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa) |
| | IFNB1 | Interferon beta. (185 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa) |
| | LOC111174575 | Cytochrome c-like. (69 aa) |
| | IRAK4 | Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa) |
| | CFL2 | Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | LOC111174480 | C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | LOC111172911 | Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | GNG2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa) |
| | LOC111175787 | LOW QUALITY PROTEIN: cullin-4B-like; Belongs to the cullin family. (891 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha. (314 aa) |
| | JUN | Transcription factor AP-1; Belongs to the bZIP family. (343 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | TBK1 | Serine/threonine-protein kinase TBK1. (729 aa) |
| | KRAS | GTPase KRas. (188 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa) |
| | LOC111174031 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa) |
| | LOC111174197 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa) |
| | FOS | Proto-oncogene c-Fos. (380 aa) |
| | DCAF1 | DDB1- and CUL4-associated factor 1 isoform X1. (1540 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(Q) subunit alpha isoform X1. (359 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (541 aa) |
| | CCNB2 | G2/mitotic-specific cyclin-B2 isoform X1; Belongs to the cyclin family. (398 aa) |
| | WEE2 | Wee1-like protein kinase 2. (419 aa) |
| | LOC111175930 | Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | CALML4 | Calmodulin-like protein 4 isoform X1. (189 aa) |
| | TLR4 | Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | CUL4A | cullin-4A; Belongs to the cullin family. (761 aa) |
| | CUL1 | Cullin-1; Belongs to the cullin family. (776 aa) |
| | LOC111176690 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa) |
| | LOC111178659 | Antigen peptide transporter 2-like isoform X4. (758 aa) |
| | BAK1 | Bcl-2 homologous antagonist/killer isoform X1. (239 aa) |
| | GNB5 | Guanine nucleotide-binding protein subunit beta-5 isoform X1. (414 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | CALM1 | Calmodulin-1; Belongs to the calmodulin family. (149 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (193 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | LOC111177332 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A. (445 aa) |
| | AP1G1 | AP-1 complex subunit gamma. (825 aa) |
| | TAP1 | Antigen peptide transporter 1 isoform X1. (750 aa) |
| | TAPBP | Tapasin isoform X1. (451 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa) |
| | GNG5 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | IRF3 | Interferon regulatory factor 3 isoform X1. (464 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa) |
| | RNF7 | RING-box protein 2 isoform X1. (113 aa) |
| | ATR | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. (2655 aa) |
| | BAX | Apoptosis regulator BAX isoform X2. (223 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | BCL2 | Apoptosis regulator Bcl-2. (233 aa) |
| | NFATC3 | Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa) |
| | LIMK1 | LIM domain kinase 1 isoform X1. (647 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa) |
| | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa) |
| | NRAS | GTPase NRas. (189 aa) |
| | LOC111180543 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa) |
| | CDC25C | M-phase inducer phosphatase 3. (500 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa) |
| | AP1S1 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa) |
| | GNG8 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (594 aa) |
| | PRKCB | Protein kinase C. (689 aa) |
| | MB21D1 | Cyclic GMP-AMP synthase. (513 aa) |
| | LOC111181647 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa) |
| | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (544 aa) |
| | CFL1 | Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | LOC111181648 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (192 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1. (628 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | SKP1 | S-phase kinase-associated protein 1 isoform X1; Belongs to the SKP1 family. (164 aa) |
| | TMEM173 | Stimulator of interferon genes protein. (431 aa) |
| | RELA | Transcription factor p65 isoform X1. (562 aa) |
| | LOC111184277 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa) |
| | GNG13 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (543 aa) |
| | DDB1 | DNA damage-binding protein 1. (1140 aa) |
| | BAD | Bcl2-associated agonist of cell death. (168 aa) |
| | CRK | Adapter molecule crk isoform X1. (304 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | BCL2L1 | Bcl-2-like protein 1 isoform X1. (233 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa) |
| | RBX1 | E3 ubiquitin-protein ligase RBX1. (108 aa) |
| | ELOC | elongin-C; Belongs to the SKP1 family. (112 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa) |
| | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa) |
| | LOC111186177 | DNA dC->dU-editing enzyme APOBEC-3B-like isoform X1. (417 aa) |
| | ELOB | elongin-B. (118 aa) |
| | CASP9 | Caspase-9; Belongs to the peptidase C14A family. (452 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (456 aa) |
| | PTK2B | Protein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa) |
| | FBXW11 | F-box/WD repeat-containing protein 11 isoform X1. (563 aa) |
| | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B. (454 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | LOC111186179 | DNA dC->dU-editing enzyme APOBEC-3G-like. (194 aa) |
| | CALML6 | Calmodulin-like protein 6 isoform X2. (227 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (366 aa) |
| | PPP3R1 | Calcineurin subunit B type 1. (170 aa) |
| | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa) |
| | PPP3R2 | LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa) |
| | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa) |
| | TLR2 | Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (455 aa) |
