STRINGSTRING
RANBP1 RANBP1 LOC111163175 LOC111163175 CDC42 CDC42 USP7 USP7 MAPK1 MAPK1 UBR4 UBR4 GTF2B GTF2B IRF9 IRF9 CCR4 CCR4 CDKN2B CDKN2B KAT2B KAT2B RBL2 RBL2 YWHAQ YWHAQ YWHAH YWHAH LOC111164829 LOC111164829 ATP6V0D2 ATP6V0D2 DDX3X DDX3X TBPL1 TBPL1 STAT5A STAT5A LOC111166483 LOC111166483 STAT3 STAT3 LOC111166690 LOC111166690 PIK3R2 PIK3R2 HNRNPK HNRNPK LOC111164824 LOC111164824 PRKACA PRKACA LYN LYN C3 C3 CREB3L4 CREB3L4 KAT2A KAT2A CDK1 CDK1 JAK3 JAK3 LOC111168449 LOC111168449 LOC111168524 LOC111168524 LOC111168528 LOC111168528 LOC111168549 LOC111168549 CREB3L3 CREB3L3 LOC111168445 LOC111168445 LOC111168525 LOC111168525 LOC111168529 LOC111168529 EGR3 EGR3 LOC111168526 LOC111168526 LOC111168530 LOC111168530 CCR8 CCR8 HDAC6 HDAC6 LOC111169749 LOC111169749 IRF7 IRF7 CHEK1 CHEK1 LOC111168446 LOC111168446 LOC111168460 LOC111168460 HDAC5 HDAC5 LOC111168527 LOC111168527 LOC111168531 LOC111168531 EGR2 EGR2 SYK SYK HRAS HRAS GTF2H4 GTF2H4 LOC111170864 LOC111170864 ATF6B ATF6B TBP TBP LOC111168448 LOC111168448 LOC111170644 LOC111170644 LOC111168523 LOC111168523 LOC111168544 LOC111168544 HDAC11 HDAC11 LOC111171120 LOC111171120 GTF2E1 GTF2E1 LOC111169315 LOC111169315 MAD1L1 MAD1L1 CASP8 CASP8 DLG1 DLG1 LOC111169736 LOC111169736 MRPS18B MRPS18B IKBKG IKBKG LOC111171155 LOC111171155 HDAC8 HDAC8 CREB1 CREB1 LOC111171912 LOC111171912 HDAC4 HDAC4 CDK4 CDK4 ACTN1 ACTN1 PIK3CA PIK3CA CDK2 CDK2 CASP3 CASP3 HDAC7 HDAC7 CCR3 CCR3 NFKB2 NFKB2 VDAC3 VDAC3 LOC111175442 LOC111175442 HDAC1 HDAC1 LOC111174480 LOC111174480 ATF2 ATF2 GTF2A1L GTF2A1L EIF2AK2 EIF2AK2 PIK3R3 PIK3R3 PSMC1 PSMC1 NFKBIA NFKBIA JUN JUN RHOA RHOA CCNA1 CCNA1 TRAF3 TRAF3 GTF2E2 GTF2E2 POLB POLB MDM2 MDM2 LTBR LTBR CHD4 CHD4 LOC111176743 LOC111176743 KRAS KRAS CCND2 CCND2 SNW1 SNW1 GSN GSN TRAF2 TRAF2 CDC20 CDC20 BAK1 BAK1 CCND3 CCND3 SRF SRF GTF2A1 GTF2A1 RASA2 RASA2 TRAF1 TRAF1 CDKN1A CDKN1A PRKACB PRKACB CDKN1B CDKN1B LOC111179149 LOC111179149 PKM PKM CREB3L2 CREB3L2 PIK3CB PIK3CB GTF2A2 GTF2A2 GTF2H1 GTF2H1 SND1 SND1 CDK6 CDK6 IRF3 IRF3 JAK1 JAK1 NFKB1 NFKB1 PMAIP1 PMAIP1 CCNE2 CCNE2 ACTN4 ACTN4 CCNE1 CCNE1 BAX BAX ATP6V0D1 ATP6V0D1 TRADD TRADD SCIN SCIN HDAC9 HDAC9 VAC14 VAC14 CREB5 CREB5 YWHAZ YWHAZ NRAS NRAS MAPK3 MAPK3 HPN HPN GRB2 GRB2 RAC1 RAC1 YWHAG YWHAG CCND1 CCND1 RELA RELA CREB3L1 CREB3L1 RBL1 RBL1 HDAC3 HDAC3 SRC SRC RBPJL RBPJL MAPKAPK2 MAPKAPK2 DDB1 DDB1 BAD BAD YWHAB YWHAB CCNA2 CCNA2 CREBBP CREBBP ATF4 ATF4 TRAF5 TRAF5 DNAJA3 DNAJA3 HDAC10 HDAC10 EP300 EP300 IL6ST IL6ST YWHAE YWHAE GTF2H3 GTF2H3 PIK3R1 PIK3R1 SKP2 SKP2 REL REL PIK3CD PIK3CD UBE3A UBE3A CREB3 CREB3 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RANBP1Ran-specific GTPase-activating protein. (206 aa)
LOC111163175Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
USP7LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1102 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
UBR4E3 ubiquitin-protein ligase UBR4 isoform X1. (5220 aa)
GTF2BTranscription initiation factor IIB. (316 aa)
IRF9LOW QUALITY PROTEIN: interferon regulatory factor 9. (479 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (131 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (828 aa)
RBL2Retinoblastoma-like protein 2. (1083 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
LOC111164829Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (473 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC111166690H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1; Belongs to the MHC class I family. (559 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K isoform X1. (464 aa)
LOC111164824Histone deacetylase 2-like isoform X1. (260 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LYNTyrosine-protein kinase. (518 aa)
C3Complement C3 isoform X1. (1695 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (878 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
LOC111168449Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168524Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168528Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168549Histone H2B; Belongs to the histone H2B family. (127 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
LOC111168445Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168525Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168529Histone H2B; Belongs to the histone H2B family. (126 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
LOC111168526Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168530Histone H2B; Belongs to the histone H2B family. (126 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (353 aa)
HDAC6Histone deacetylase 6 isoform X1. (1149 aa)
LOC111169749Histone H2B; Belongs to the histone H2B family. (126 aa)
IRF7Interferon regulatory factor 7 isoform X1. (473 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1. (540 aa)
LOC111168446Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168460Histone H2B; Belongs to the histone H2B family. (127 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
LOC111168527Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168531Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (112 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (422 aa)
SYKTyrosine-protein kinase. (626 aa)
HRASGTPase HRas isoform X1. (189 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
LOC111170864Recombining binding protein suppressor of hairless isoform X1. (500 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
TBPTATA-box-binding protein. (319 aa)
LOC111168448Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111170644BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1; Belongs to the MHC class I family. (360 aa)
LOC111168523Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111168544Histone H2B type 1-L-like; Belongs to the histone H2B family. (143 aa)
HDAC11Histone deacetylase 11. (347 aa)
LOC111171120Late histone H2B.L4-like; Belongs to the histone H2B family. (135 aa)
GTF2E1General transcription factor IIE subunit 1. (438 aa)
LOC111169315Histone H2B; Belongs to the histone H2B family. (126 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X2. (735 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
LOC111169736Histone H2B; Belongs to the histone H2B family. (197 aa)
MRPS18B28S ribosomal protein S18b, mitochondrial. (292 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
LOC111171155Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC8Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (424 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
LOC111171912Nuclear body protein SP140-like protein isoform X1. (694 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ACTN1Alpha-actinin-1 isoform X2. (914 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1049 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (900 aa)
VDAC3Voltage-dependent anion-selective channel protein 3. (283 aa)
LOC11117544214-3-3 protein gamma-like; Belongs to the 14-3-3 family. (153 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
LOC111174480C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
GTF2A1LTFIIA-alpha and beta-like factor. (533 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (539 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PSMC126S proteasome regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (421 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1940 aa)
LOC111176743Histone H2B; Belongs to the histone H2B family. (122 aa)
KRASGTPase KRas. (188 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
SNW1SNW domain-containing protein 1. (536 aa)
GSNGelsolin isoform X1. (770 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
SRFSerum response factor isoform X2. (535 aa)
GTF2A1Transcription initiation factor IIA subunit 1. (375 aa)
RASA2Ras GTPase-activating protein 2 isoform X1. (848 aa)
TRAF1TNF receptor-associated factor. (415 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LOC11117914914-3-3 protein gamma-like; Belongs to the 14-3-3 family. (246 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
IRF3Interferon regulatory factor 3 isoform X1. (464 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
ACTN4Alpha-actinin-4 isoform X5. (933 aa)
CCNE1G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
SCINAdseverin isoform X1. (715 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1043 aa)
VAC14Protein VAC14 homolog. (783 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
NRASGTPase NRas. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
HPNSerine protease hepsin isoform X1; Belongs to the peptidase S1 family. (599 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RELATranscription factor p65 isoform X1. (562 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1073 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
SRCTyrosine-protein kinase. (562 aa)
RBPJLRecombining binding protein suppressor of hairless-like protein. (516 aa)
MAPKAPK2LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (414 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
BADBcl2-associated agonist of cell death. (168 aa)
YWHAB14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa)
DNAJA3dnaJ homolog subfamily A member 3, mitochondrial isoform X1. (480 aa)
HDAC10Histone deacetylase 10 isoform X1. (677 aa)
EP300Histone acetyltransferase p300. (2420 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
GTF2H3General transcription factor IIH subunit 3 isoform X1. (313 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
SKP2S-phase kinase-associated protein 2 isoform X1. (436 aa)
RELProto-oncogene c-Rel. (594 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (20%) [HD]