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| | CRKL | Crk-like protein. (303 aa) |
| | LOC111163175 | Cyclin-dependent kinase inhibitor 2A-like. (152 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (215 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (380 aa) |
| | E2F2 | Transcription factor E2F2 isoform X1. (437 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (149 aa) |
| | ABCC1 | Multidrug resistance-associated protein 1. (1530 aa) |
| | MARCKS | Myristoylated alanine-rich C-kinase substrate. (334 aa) |
| | LOC111164829 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (473 aa) |
| | ST14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (855 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (805 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa) |
| | TRIM71 | E3 ubiquitin-protein ligase TRIM71. (872 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K isoform X1. (464 aa) |
| | LOC111164824 | Histone deacetylase 2-like isoform X1. (260 aa) |
| | SHC1 | SHC-transforming protein 1 isoform X1. (609 aa) |
| | EFNA3 | ephrin-A3 isoform X1; Belongs to the ephrin family. (238 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1654 aa) |
| | EZR | Ezrin. (586 aa) |
| | EFNA4 | ephrin-A4 isoform X1; Belongs to the ephrin family. (204 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | TNN | tenascin-N. (1296 aa) |
| | TNR | tenascin-R isoform X1. (1358 aa) |
| | RDX | Radixin isoform X2. (604 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1 isoform X1. (577 aa) |
| | NOTCH3 | Neurogenic locus notch homolog protein 3 isoform X1. (2336 aa) |
| | PDGFA | Platelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | EFNA1 | ephrin-A1 isoform X3; Belongs to the ephrin family. (211 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa) |
| | HRAS | GTPase HRas isoform X1. (189 aa) |
| | NOTCH4 | Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa) |
| | GLS | Glutaminase kidney isoform, mitochondrial isoform X1. (686 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | MMP16 | Matrix metalloproteinase-16. (548 aa) |
| | IRS1 | Insulin receptor substrate 1. (1248 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa) |
| | MMP9 | Matrix metalloproteinase-9. (709 aa) |
| | EFNA2 | ephrin-A2; Belongs to the ephrin family. (214 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1. (351 aa) |
| | HOXD10 | Homeobox protein Hox-D10. (340 aa) |
| | FSCN1 | Fascin. (493 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa) |
| | SOS2 | Son of sevenless homolog 2 isoform X1. (1332 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | ERBB3 | Receptor tyrosine-protein kinase erbB-3. (1338 aa) |
| | CASP3 | Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa) |
| | ZEB2 | Zinc finger E-box-binding homeobox 2 isoform X1. (1244 aa) |
| | GLS2 | Glutaminase liver isoform, mitochondrial isoform X1. (602 aa) |
| | CDC25A | M-phase inducer phosphatase 1 isoform X1. (524 aa) |
| | PDCD4 | Programmed cell death protein 4 isoform X1. (469 aa) |
| | PRKCE | Protein kinase C. (746 aa) |
| | SOS1 | Son of sevenless homolog 1 isoform X1. (1333 aa) |
| | DNMT3A | DNA (Cytosine-5)-methyltransferase 3A isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (910 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | HMGA2 | High mobility group protein HMGI-C. (109 aa) |
| | SLC7A1 | High affinity cationic amino acid transporter 1. (629 aa) |
| | HDAC1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa) |
| | RASSF1 | Ras association domain-containing protein 1 isoform X1. (340 aa) |
| | RHOA | Transforming protein RhoA. (193 aa) |
| | IRS2 | Insulin receptor substrate 2. (1347 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (800 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa) |
| | LOC111174870 | Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa) |
| | KRAS | GTPase KRas. (188 aa) |
| | DICER1 | Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1921 aa) |
| | FOXP1 | Forkhead box protein P1 isoform X1. (673 aa) |
| | CCND2 | G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | BMI1 | Polycomb complex protein BMI-1. (326 aa) |
| | SPRY2 | Protein sprouty homolog 2. (315 aa) |
| | BAK1 | Bcl-2 homologous antagonist/killer isoform X1. (239 aa) |
| | VEGFA | Vascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa) |
| | KIF23 | LOW QUALITY PROTEIN: kinesin-like protein KIF23; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1234 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1. (164 aa) |
| | PIM1 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (347 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B. (198 aa) |
| | TPM1 | Tropomyosin alpha-1 chain isoform X19; Belongs to the tropomyosin family. (326 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa) |
| | MET | Hepatocyte growth factor receptor isoform X1. (1382 aa) |
| | ABL1 | Tyrosine-protein kinase. (1148 aa) |
| | EZH2 | Histone-lysine N-methyltransferase EZH2 isoform X1. (747 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa) |
| | TNC | Tenascin isoform X1. (2201 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ZFPM2 | Zinc finger protein ZFPM2. (1151 aa) |
| | ZEB1 | Zinc finger E-box-binding homeobox 1 isoform X2. (1110 aa) |
| | CDK6 | Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa) |
| | SERPINB5 | Serpin B5; Belongs to the serpin family. (375 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa) |
| | CCNE2 | G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa) |
| | SOX4 | Transcription factor SOX. (477 aa) |
| | CCNE1 | G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa) |
| | CD44 | CD44 antigen isoform X1. (742 aa) |
| | BCL2 | Apoptosis regulator Bcl-2. (233 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | NRAS | GTPase NRas. (189 aa) |
| | CDC25C | M-phase inducer phosphatase 3. (500 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (789 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | ABCB1 | LOW QUALITY PROTEIN: multidrug resistance protein 1. (1286 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (594 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa) |
| | PRKCB | Protein kinase C. (689 aa) |
| | PLAU | Urokinase-type plasminogen activator. (431 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa) |
| | E2F3 | LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa) |
| | RPTOR | Regulatory-associated protein of mTOR isoform X7. (1335 aa) |
| | GRB2 | Growth factor receptor-bound protein 2. (217 aa) |
| | SHC4 | SHC-transforming protein 4. (630 aa) |
| | BMF | LOW QUALITY PROTEIN: bcl-2-modifying factor. (269 aa) |
| | THBS1 | Thrombospondin-1. (1170 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa) |
| | DDIT4 | DNA damage-inducible transcript 4 protein. (229 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa) |
| | APC | Adenomatous polyposis coli protein isoform X1. (2864 aa) |
| | EFNA5 | ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa) |
| | CDC25B | M-phase inducer phosphatase 2 isoform X1. (574 aa) |
| | CDCA5 | Sororin. (253 aa) |
| | SLC45A3 | Solute carrier family 45 member 3. (553 aa) |
| | DNMT3B | DNA (Cytosine-5)-methyltransferase 3B; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (836 aa) |
| | CRK | Adapter molecule crk isoform X1. (304 aa) |
| | E2F1 | Transcription factor E2F1. (437 aa) |
| | FZD3 | Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | CREBBP | CREB-binding protein isoform X1. (2442 aa) |
| | PDGFB | Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2. (604 aa) |
| | MDM4 | Protein Mdm4 isoform X2. (391 aa) |
| | LOC111186695 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (514 aa) |
| | UBE2I | SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | EP300 | Histone acetyltransferase p300. (2420 aa) |
| | BCL2L11 | Bcl-2-like protein 11 isoform X1. (288 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | TIMP3 | Metalloproteinase inhibitor 3. (211 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa) |
| | HMOX1 | Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa) |
| | RECK | Reversion-inducing cysteine-rich protein with Kazal motifs isoform X1. (971 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa) |
