STRINGSTRING
MAPK1 MAPK1 RPS6KB1 RPS6KB1 MYC MYC TGFBR2 TGFBR2 MAP2K2 MAP2K2 MLH1 MLH1 TCF7L1 TCF7L1 PIK3R2 PIK3R2 ARAF ARAF GADD45G GADD45G TGFA TGFA MAPK10 MAPK10 CTNNB1 CTNNB1 GSK3B GSK3B RALB RALB HRAS HRAS MAPK9 MAPK9 GADD45B GADD45B LEF1 LEF1 MAPK8 MAPK8 RAF1 RAF1 TCF7L2 TCF7L2 SOS2 SOS2 PIK3CA PIK3CA CASP3 CASP3 APPL1 APPL1 MSH6 MSH6 LOC111174575 LOC111174575 SOS1 SOS1 LOC111172911 LOC111172911 PIK3R3 PIK3R3 JUN JUN RHOA RHOA AKT1 AKT1 KRAS KRAS LOC111174031 LOC111174031 LOC111174197 LOC111174197 FOS FOS AKT3 AKT3 LOC111175930 LOC111175930 MSH2 MSH2 TGFB2 TGFB2 RALGDS RALGDS BAK1 BAK1 BRAF BRAF GADD45A GADD45A TGFB3 TGFB3 CDKN1A CDKN1A SMAD3 SMAD3 SMAD4 SMAD4 PIK3CB PIK3CB SMAD2 SMAD2 MAP2K1 MAP2K1 PMAIP1 PMAIP1 TGFB1 TGFB1 BAX BAX BCL2 BCL2 NRAS NRAS LOC111180543 LOC111180543 TCF7 TCF7 RAC3 RAC3 AKT2 AKT2 MAPK3 MAPK3 BBC3 BBC3 BIRC5 BIRC5 RPS6KB2 RPS6KB2 GRB2 GRB2 AXIN2 AXIN2 RAC1 RAC1 CCND1 CCND1 APC APC MSH3 MSH3 BAD BAD DDB2 DDB2 AXIN1 AXIN1 POLK POLK RAC2 RAC2 RALA RALA EGFR EGFR CASP9 CASP9 BCL2L11 BCL2L11 AREG AREG PIK3R1 PIK3R1 MTOR MTOR EREG EREG TGFBR1 TGFBR1 PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
MLH1DNA mismatch repair protein Mlh1 isoform X1. (758 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (601 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CTNNB1Catenin beta-1. (781 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
RALBRas-related protein Ral-B. (206 aa)
HRASGTPase HRas isoform X1. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (708 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
LOC111174575Cytochrome c-like. (69 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
LOC111172911Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KRASGTPase KRas. (188 aa)
LOC111174031Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC111174197Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
FOSProto-oncogene c-Fos. (380 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
LOC111175930Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (871 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
NRASGTPase NRas. (189 aa)
LOC111180543Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TCF7Transcription factor 7 isoform X1. (415 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
BBC3Bcl-2-binding component 3. (193 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AXIN2Axin-2 isoform X1. (843 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
APCAdenomatous polyposis coli protein isoform X1. (2864 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1129 aa)
BADBcl2-associated agonist of cell death. (168 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
AXIN1Axin-1 isoform X1. (866 aa)
POLKDNA polymerase kappa. (878 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
RALARas-related protein Ral-A. (206 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (288 aa)
AREGAmphiregulin isoform X1. (254 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
EREGProepiregulin. (163 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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