STRINGSTRING
CRKL CRKL CDC42 CDC42 MAPK1 MAPK1 EGLN1 EGLN1 HGF HGF ARNT2 ARNT2 ETS1 ETS1 PAK5 PAK5 MAP2K2 MAP2K2 PIK3R2 PIK3R2 ARAF ARAF FLCN FLCN TGFA TGFA PAK3 PAK3 PRCC PRCC HRAS HRAS TFE3 TFE3 RAF1 RAF1 ARNT ARNT LOC111169978 LOC111169978 PAK2 PAK2 EGLN3 EGLN3 HIF1A HIF1A SOS2 SOS2 PIK3CA PIK3CA EPAS1 EPAS1 SOS1 SOS1 PIK3R3 PIK3R3 JUN JUN AKT1 AKT1 RAP1B RAP1B KRAS KRAS RAPGEF1 RAPGEF1 AKT3 AKT3 FH FH TGFB2 TGFB2 SLC2A1 SLC2A1 BRAF BRAF VEGFA VEGFA TGFB3 TGFB3 CUL2 CUL2 CDKN1A CDKN1A MET MET PIK3CB PIK3CB MAP2K1 MAP2K1 EGLN2 EGLN2 RAP1A RAP1A TGFB1 TGFB1 NRAS NRAS AKT2 AKT2 MAPK3 MAPK3 PAK4 PAK4 GRB2 GRB2 RAC1 RAC1 PAK1 PAK1 BAD BAD CRK CRK CREBBP CREBBP RBX1 RBX1 PDGFB PDGFB ELOC ELOC ELOB ELOB EP300 EP300 PIK3R1 PIK3R1 GAB1 GAB1 PTPN11 PTPN11 LOC111187198 LOC111187198 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKLCrk-like protein. (303 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
EGLN1Egl nine homolog 1. (439 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2 isoform X1. (717 aa)
ETS1Protein C-ets-1 isoform X1. (486 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
FLCNFolliculin isoform X1. (591 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
PRCCProline-rich protein PRCC. (492 aa)
HRASGTPase HRas isoform X1. (189 aa)
TFE3Transcription factor E3 isoform X1. (575 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
LOC111169978Von Hippel-Lindau disease tumor suppressor. (166 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
EGLN3Egl nine homolog 3. (239 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EPAS1Endothelial PAS domain-containing protein 1 isoform X1. (866 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
KRASGTPase KRas. (188 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1259 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
FHFumarate hydratase, mitochondrial. (510 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
CUL2Cullin-2; Belongs to the cullin family. (745 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
EGLN2Egl nine homolog 2. (402 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
NRASGTPase NRas. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PAK4Non-specific serine/threonine protein kinase. (594 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
ELOCelongin-C; Belongs to the SKP1 family. (112 aa)
ELOBelongin-B. (118 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC111187198Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (617 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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