STRINGSTRING
RALBP1 RALBP1 LOC111163175 LOC111163175 CDC42 CDC42 MAPK1 MAPK1 E2F2 E2F2 RPS6KB1 RPS6KB1 TGFBR2 TGFBR2 STAT3 STAT3 ARHGEF6 ARHGEF6 PIK3R2 PIK3R2 ARAF ARAF ERBB2 ERBB2 GADD45G GADD45G TGFA TGFA MAPK10 MAPK10 RALB RALB MAPK9 MAPK9 GADD45B GADD45B MAPK8 MAPK8 RAF1 RAF1 STAT1 STAT1 IKBKG IKBKG CDK4 CDK4 PIK3CA PIK3CA CHUK CHUK PLD1 PLD1 IKBKB IKBKB PIK3R3 PIK3R3 AKT1 AKT1 KRAS KRAS AKT3 AKT3 TGFB2 TGFB2 BRCA2 BRCA2 RALGDS RALGDS BAK1 BAK1 BRAF BRAF VEGFA VEGFA GADD45A GADD45A TGFB3 TGFB3 CDKN1A CDKN1A SMAD3 SMAD3 SMAD4 SMAD4 PIK3CB PIK3CB SMAD2 SMAD2 MAP2K1 MAP2K1 CDK6 CDK6 JAK1 JAK1 NFKB1 NFKB1 TGFB1 TGFB1 BAX BAX RAD51 RAD51 RAC3 RAC3 AKT2 AKT2 MAPK3 MAPK3 E2F3 E2F3 RPS6KB2 RPS6KB2 RAC1 RAC1 CCND1 CCND1 RELA RELA BAD BAD DDB2 DDB2 PLD2 PLD2 E2F1 E2F1 POLK POLK BCL2L1 BCL2L1 RAC2 RAC2 RALA RALA EGFR EGFR CASP9 CASP9 PIK3R1 PIK3R1 MTOR MTOR TGFBR1 TGFBR1 PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RALBP1ralA-binding protein 1. (635 aa)
LOC111163175Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6 isoform X1. (780 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
RALBRas-related protein Ral-B. (206 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
PLD1Phospholipase. (1151 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KRASGTPase KRas. (188 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (871 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
E2F3LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RELATranscription factor p65 isoform X1. (562 aa)
BADBcl2-associated agonist of cell death. (168 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
PLD2Phospholipase. (933 aa)
E2F1Transcription factor E2F1. (437 aa)
POLKDNA polymerase kappa. (878 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
RALARas-related protein Ral-A. (206 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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