STRINGSTRING
LOC111163175 LOC111163175 MAPK1 MAPK1 E2F2 E2F2 MAP2K2 MAP2K2 PIK3R2 PIK3R2 ARAF ARAF SHC1 SHC1 GADD45G GADD45G TGFA TGFA SHC3 SHC3 PDGFA PDGFA PDGFRA PDGFRA HRAS HRAS GADD45B GADD45B RAF1 RAF1 SHC2 SHC2 CDK4 CDK4 SOS2 SOS2 PIK3CA PIK3CA SOS1 SOS1 PTEN PTEN PIK3R3 PIK3R3 AKT1 AKT1 MDM2 MDM2 KRAS KRAS AKT3 AKT3 CALML4 CALML4 CAMK1D CAMK1D BAK1 BAK1 BRAF BRAF CALM1 CALM1 GADD45A GADD45A CDKN1A CDKN1A PLCG2 PLCG2 PIK3CB PIK3CB MAP2K1 MAP2K1 CDK6 CDK6 BAX BAX NRAS NRAS AKT2 AKT2 MAPK3 MAPK3 PRKCB PRKCB CAMK2G CAMK2G PRKCA PRKCA E2F3 E2F3 GRB2 GRB2 SHC4 SHC4 PDGFRB PDGFRB PLCG1 PLCG1 CCND1 CCND1 CAMK2A CAMK2A DDB2 DDB2 E2F1 E2F1 POLK POLK CAMK2D CAMK2D CAMK2B CAMK2B PDGFB PDGFB EGFR EGFR CAMK1G CAMK1G PIK3R1 PIK3R1 CALML6 CALML6 MTOR MTOR IGF1R IGF1R IGF1 IGF1 PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111163175Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
SHC3SHC-transforming protein 3. (588 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
HRASGTPase HRas isoform X1. (189 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
KRASGTPase KRas. (188 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
CALML4Calmodulin-like protein 4 isoform X1. (189 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D isoform X1. (435 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
NRASGTPase NRas. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (610 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
E2F3LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
E2F1Transcription factor E2F1. (437 aa)
POLKDNA polymerase kappa. (878 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (542 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G; Belongs to the protein kinase superfamily. (476 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CALML6Calmodulin-like protein 6 isoform X2. (227 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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