STRINGSTRING
MAPK1 MAPK1 MYC MYC RET RET MAP2K2 MAP2K2 TCF7L1 TCF7L1 TPM3 TPM3 NTRK1 NTRK1 GADD45G GADD45G LOC111168952 LOC111168952 CTNNB1 CTNNB1 CCDC6 CCDC6 HRAS HRAS GADD45B GADD45B LEF1 LEF1 NCOA4 NCOA4 RXRG RXRG TCF7L2 TCF7L2 LOC111174776 LOC111174776 KRAS KRAS RXRA RXRA BAK1 BAK1 BRAF BRAF GADD45A GADD45A CDKN1A CDKN1A MAP2K1 MAP2K1 RXRB RXRB BAX BAX CDH1 CDH1 NRAS NRAS TCF7 TCF7 MAPK3 MAPK3 CCND1 CCND1 TFG TFG TPR TPR DDB2 DDB2 POLK POLK PAX8 PAX8 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (601 aa)
TPM3Tropomyosin alpha-3 chain isoform X5; Belongs to the tropomyosin family. (284 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC111168952Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (933 aa)
CTNNB1Catenin beta-1. (781 aa)
CCDC6Coiled-coil domain-containing protein 6. (476 aa)
HRASGTPase HRas isoform X1. (189 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
NCOA4Nuclear receptor coactivator 4 isoform X1. (625 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
LOC111174776Tropomyosin alpha-3 chain-like. (185 aa)
KRASGTPase KRas. (188 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (495 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (538 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
NRASGTPase NRas. (189 aa)
TCF7Transcription factor 7 isoform X1. (415 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
TFGProtein TFG isoform X1. (400 aa)
TPRNucleoprotein TPR isoform X2. (2438 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
POLKDNA polymerase kappa. (878 aa)
PAX8Paired box protein Pax-8. (457 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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