STRINGSTRING
LOC111163175 LOC111163175 MAPK1 MAPK1 E2F2 E2F2 MYC MYC DAPK3 DAPK3 FGFR3 FGFR3 MAP2K2 MAP2K2 ARAF ARAF DAPK1 DAPK1 MMP2 MMP2 ERBB2 ERBB2 MMP1 MMP1 HRAS HRAS RAF1 RAF1 MMP9 MMP9 CDK4 CDK4 RASSF1 RASSF1 RPS6KA5 RPS6KA5 MDM2 MDM2 KRAS KRAS BRAF BRAF VEGFA VEGFA CDKN1A CDKN1A DAPK2 DAPK2 MAP2K1 MAP2K1 CDH1 CDH1 NRAS NRAS MAPK3 MAPK3 HBEGF HBEGF E2F3 E2F3 THBS1 THBS1 CCND1 CCND1 SRC SRC E2F1 E2F1 EGFR EGFR UPK3A UPK3A CXCL8 CXCL8 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111163175Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
DAPK1Death-associated protein kinase 1 isoform X1. (1440 aa)
MMP272 kDa type IV collagenase. (661 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MMP1Interstitial collagenase isoform X1. (554 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RASSF1Ras association domain-containing protein 1 isoform X1. (340 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
KRASGTPase KRas. (188 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
DAPK2Death-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (365 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
NRASGTPase NRas. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
E2F3LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa)
THBS1Thrombospondin-1. (1170 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
SRCTyrosine-protein kinase. (562 aa)
E2F1Transcription factor E2F1. (437 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
UPK3AUroplakin-3a isoform X1. (287 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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