STRINGSTRING
LAMA1 LAMA1 E2F2 E2F2 MYC MYC CDKN2B CDKN2B LAMA4 LAMA4 RARB RARB COL4A5 COL4A5 PIK3R2 PIK3R2 COL4A6 COL4A6 CKS1B CKS1B ITGA3 ITGA3 GADD45G GADD45G CKS2 CKS2 BIRC3 BIRC3 XIAP XIAP LAMA2 LAMA2 LOC111168369 LOC111168369 ITGA2B ITGA2B GADD45B GADD45B COL4A4 COL4A4 COL4A3 COL4A3 RXRG RXRG ITGAV ITGAV IKBKG IKBKG CDK4 CDK4 MAX MAX PIK3CA PIK3CA CHUK CHUK CDK2 CDK2 CASP3 CASP3 IKBKB IKBKB FN1 FN1 FHIT FHIT LOC111174575 LOC111174575 PTEN PTEN ITGA6 ITGA6 LOC111172911 LOC111172911 PIK3R3 PIK3R3 NFKBIA NFKBIA AKT1 AKT1 TRAF3 TRAF3 COL4A2 COL4A2 LOC111174031 LOC111174031 LOC111174197 LOC111174197 LAMB2 LAMB2 AKT3 AKT3 LOC111175930 LOC111175930 TRAF2 TRAF2 RXRA RXRA COL4A1 COL4A1 LAMC3 LAMC3 BAK1 BAK1 GADD45A GADD45A TRAF1 TRAF1 CDKN1A CDKN1A CDKN1B CDKN1B ITGB1 ITGB1 PIK3CB PIK3CB CDK6 CDK6 NFKB1 NFKB1 RXRB RXRB CCNE2 CCNE2 LAMA3 LAMA3 CCNE1 CCNE1 BAX BAX BCL2 BCL2 TRAF6 TRAF6 LOC111180543 LOC111180543 AKT2 AKT2 E2F3 E2F3 CCND1 CCND1 RELA RELA LAMC2 LAMC2 LAMB1 LAMB1 LAMB4 LAMB4 LAMB3 LAMB3 DDB2 DDB2 E2F1 E2F1 POLK POLK BCL2L1 BCL2L1 PTGS2 PTGS2 LAMC1 LAMC1 TRAF5 TRAF5 LOC111185989 LOC111185989 CASP9 CASP9 TRAF4 TRAF4 LAMA5 LAMA5 PIK3R1 PIK3R1 SKP2 SKP2 ITGA2 ITGA2 APAF1 APAF1 ZBTB17 ZBTB17 PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMA1Laminin subunit alpha-1 isoform X1. (3081 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (131 aa)
LAMA4Laminin subunit alpha-4 isoform X1. (1824 aa)
RARBRetinoic acid receptor beta isoform X1. (448 aa)
COL4A5Collagen alpha-5(IV) chain. (1685 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
COL4A6Collagen alpha-6(IV) chain. (1706 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ITGA3Integrin alpha-3 isoform X1; Belongs to the integrin alpha chain family. (1068 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
BIRC3Baculoviral IAP repeat-containing protein 3 isoform X1. (604 aa)
XIAPE3 ubiquitin-protein ligase XIAP isoform X1. (497 aa)
LAMA2Laminin subunit alpha-2. (3008 aa)
LOC111168369Baculoviral IAP repeat-containing protein 2. (620 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (1034 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
COL4A4Collagen alpha-4(IV) chain. (1686 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MAXProtein max isoform X1. (162 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (412 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
FN1Fibronectin isoform X5. (2478 aa)
FHITBis(5'-adenosyl)-triphosphatase. (175 aa)
LOC111174575Cytochrome c-like. (69 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1091 aa)
LOC111172911Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
COL4A2Collagen alpha-2(IV) chain isoform X1. (1760 aa)
LOC111174031Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC111174197Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
LAMB2Laminin subunit beta-2 isoform X1. (1812 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
LOC111175930Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (495 aa)
COL4A1Collagen alpha-1(IV) chain isoform X1. (1668 aa)
LAMC3Laminin subunit gamma-3. (1577 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
TRAF1TNF receptor-associated factor. (415 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (538 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (404 aa)
LAMA3Laminin subunit alpha-3 isoform X3. (3335 aa)
CCNE1G1/S-specific cyclin-E1 isoform X1; Belongs to the cyclin family. (410 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
LOC111180543Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
E2F3LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RELATranscription factor p65 isoform X1. (562 aa)
LAMC2Laminin subunit gamma-2. (1191 aa)
LAMB1Laminin subunit beta-1. (1786 aa)
LAMB4LOW QUALITY PROTEIN: laminin subunit beta-4. (1767 aa)
LAMB3Laminin subunit beta-3. (1172 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
E2F1Transcription factor E2F1. (437 aa)
POLKDNA polymerase kappa. (878 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
LAMC1Laminin subunit gamma-1. (1608 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
TRAF4TNF receptor-associated factor. (470 aa)
LAMA5Laminin subunit alpha-5. (3687 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
SKP2S-phase kinase-associated protein 2 isoform X1. (436 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17 isoform X1. (792 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.