STRINGSTRING
LOC111163175 LOC111163175 MAPK1 MAPK1 E2F2 E2F2 HGF HGF FOXO3 FOXO3 RARB RARB MAP2K2 MAP2K2 STAT5A STAT5A LOC111166483 LOC111166483 STAT3 STAT3 PIK3R2 PIK3R2 ARAF ARAF ERBB2 ERBB2 GADD45G GADD45G JAK3 JAK3 TGFA TGFA HRAS HRAS GADD45B GADD45B RAF1 RAF1 RXRG RXRG CDK4 CDK4 SOS2 SOS2 PIK3CA PIK3CA FHIT FHIT SOS1 SOS1 PIK3R3 PIK3R3 RASSF1 RASSF1 AKT1 AKT1 EML4 EML4 KRAS KRAS AKT3 AKT3 RXRA RXRA BAK1 BAK1 BRAF BRAF GADD45A GADD45A CDKN1A CDKN1A MET MET PLCG2 PLCG2 PIK3CB PIK3CB MAP2K1 MAP2K1 CDK6 CDK6 RXRB RXRB BAX BAX NRAS NRAS AKT2 AKT2 MAPK3 MAPK3 PRKCB PRKCB PRKCA PRKCA E2F3 E2F3 GRB2 GRB2 PLCG1 PLCG1 CCND1 CCND1 RASSF5 RASSF5 BAD BAD DDB2 DDB2 STK4 STK4 E2F1 E2F1 POLK POLK EGFR EGFR PDPK1 PDPK1 CASP9 CASP9 PIK3R1 PIK3R1 PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111163175Cyclin-dependent kinase inhibitor 2A-like. (152 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
FOXO3Forkhead box protein O3. (672 aa)
RARBRetinoic acid receptor beta isoform X1. (448 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (645 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
HRASGTPase HRas isoform X1. (189 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FHITBis(5'-adenosyl)-triphosphatase. (175 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
RASSF1Ras association domain-containing protein 1 isoform X1. (340 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EML4Echinoderm microtubule-associated protein-like 4 isoform X1. (992 aa)
KRASGTPase KRas. (188 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (495 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (538 aa)
BAXApoptosis regulator BAX isoform X2. (223 aa)
NRASGTPase NRas. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
E2F3LOW QUALITY PROTEIN: transcription factor E2F3. (461 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RASSF5Ras association domain-containing protein 5 isoform X1. (422 aa)
BADBcl2-associated agonist of cell death. (168 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
E2F1Transcription factor E2F1. (437 aa)
POLKDNA polymerase kappa. (878 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (452 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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