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MAPK1 MAPK1 MYC MYC RET RET PFKP PFKP FGFR3 FGFR3 MAP2K2 MAP2K2 PIK3R2 PIK3R2 NTRK1 NTRK1 SIRT6 SIRT6 ERBB2 ERBB2 LOC111167379 LOC111167379 NTRK3 NTRK3 KIT KIT PDGFRA PDGFRA HK2 HK2 HK3 HK3 HRAS HRAS PDHA1 PDHA1 SIRT3 SIRT3 IDH2 IDH2 GLS GLS RAF1 RAF1 FGFR2 FGFR2 PGAM1 PGAM1 G6PD G6PD PDK1 PDK1 HIF1A HIF1A PIK3CA PIK3CA PFKM PFKM IDH1 IDH1 GLS2 GLS2 FGFR1 FGFR1 PTEN PTEN FLT3 FLT3 PDHB PDHB PIK3R3 PIK3R3 AKT1 AKT1 KRAS KRAS SLC2A2 SLC2A2 LDHB LDHB AKT3 AKT3 TIGAR TIGAR SLC2A1 SLC2A1 MET MET PKM PKM LDHA LDHA PIK3CB PIK3CB MAP2K1 MAP2K1 PDHA2 PDHA2 SLC7A5 SLC7A5 LOC111179859 LOC111179859 NRAS NRAS AKT2 AKT2 MAPK3 MAPK3 SLC1A5 SLC1A5 PDGFRB PDGFRB HKDC1 HKDC1 HK1 HK1 SLC16A3 SLC16A3 GCK GCK PGAM2 PGAM2 EGFR EGFR LOC111186295 LOC111186295 PFKL PFKL PIK3R1 PIK3R1 MTOR MTOR PIK3CD PIK3CD TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MAPK1Mitogen-activated protein kinase. (380 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (809 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LOC111167379L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (381 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
HK2Hexokinase-2. (917 aa)
HK3Hexokinase-3 isoform X1. (924 aa)
HRASGTPase HRas isoform X1. (189 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (352 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
GLSGlutaminase kidney isoform, mitochondrial isoform X1. (686 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (555 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
GLS2Glutaminase liver isoform, mitochondrial isoform X1. (602 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KRASGTPase KRas. (188 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (541 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
TIGARFructose-2,6-bisphosphatase TIGAR isoform X1. (325 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
LDHAL-lactate dehydrogenase. (418 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDHA2Pyruvate dehydrogenase E1 component alpha subunit. (387 aa)
SLC7A5Large neutral amino acids transporter small subunit 1 isoform X1. (505 aa)
LOC111179859L-lactate dehydrogenase C chain-like isoform X2. (189 aa)
NRASGTPase NRas. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SLC1A5Amino acid transporter. (544 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (918 aa)
HK1Hexokinase-1 isoform X2. (935 aa)
SLC16A3Monocarboxylate transporter 4 isoform X1. (589 aa)
GCKPhosphotransferase. (537 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
LOC111186295Protein SCO2 homolog, mitochondrial. (266 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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