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MAPK1 MAPK1 SLC44A3 SLC44A3 RPS6KB1 RPS6KB1 WASF1 WASF1 DGKE DGKE WASF2 WASF2 LYPLA1 LYPLA1 MAP2K2 MAP2K2 DGKQ DGKQ LOC111166071 LOC111166071 PIK3R2 PIK3R2 GPCPD1 GPCPD1 SLC44A2 SLC44A2 PCYT1B PCYT1B PIP5K1C PIP5K1C MAPK10 MAPK10 LOC111169066 LOC111169066 PDGFA PDGFA WAS WAS PDGFRA PDGFRA PIP5K1A PIP5K1A PDGFD PDGFD LOC111167637 LOC111167637 SLC22A3 SLC22A3 HRAS HRAS MAPK9 MAPK9 MAPK8 MAPK8 RAF1 RAF1 DGKD DGKD PCYT1A PCYT1A PLPP2 PLPP2 EIF4EBP1 EIF4EBP1 SLC44A4 SLC44A4 DGKG DGKG DGKA DGKA HIF1A HIF1A SOS2 SOS2 PIK3CA PIK3CA PLD1 PLD1 PIP5K1B PIP5K1B SP1 SP1 SOS1 SOS1 DGKH DGKH PIK3R3 PIK3R3 JUN JUN AKT1 AKT1 RHEB RHEB PLPP3 PLPP3 KRAS KRAS FOS FOS AKT3 AKT3 RALGDS RALGDS TSC1 TSC1 SLC44A5 SLC44A5 PDGFC PDGFC PIK3CB PIK3CB MAP2K1 MAP2K1 DGKI DGKI PLA2G4F PLA2G4F NRAS NRAS PLA2G4E PLA2G4E RAC3 RAC3 AKT2 AKT2 MAPK3 MAPK3 PRKCB PRKCB SLC22A5 SLC22A5 PRKCA PRKCA DGKB DGKB RPS6KB2 RPS6KB2 GRB2 GRB2 PDGFRB PDGFRB RAC1 RAC1 PLCG1 PLCG1 SLC22A4 SLC22A4 DGKZ DGKZ CHKA CHKA PLD2 PLD2 RAC2 RAC2 PDGFB PDGFB EGFR EGFR PLA2G4A PLA2G4A TSC2 TSC2 PDPK1 PDPK1 CHKB CHKB SLC5A7 SLC5A7 PIK3R1 PIK3R1 MTOR MTOR PLPP1 PLPP1 SLC44A1 SLC44A1 PIK3CD PIK3CD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (380 aa)
SLC44A3Choline transporter-like protein 3 isoform X3; Belongs to the CTL (choline transporter-like) family. (528 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
WASF1wiskott-Aldrich syndrome protein family member 1. (559 aa)
DGKEDiacylglycerol kinase. (578 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
LYPLA1Acyl-protein thioesterase 1. (230 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1; Belongs to the protein kinase superfamily. (400 aa)
DGKQDiacylglycerol kinase. (976 aa)
LOC111166071Phospholipid phosphatase 3-like. (264 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
GPCPD1Glycerophosphocholine phosphodiesterase GPCPD1 isoform X1. (672 aa)
SLC44A2Choline transporter-like protein 2 isoform X1; Belongs to the CTL (choline transporter-like) family. (710 aa)
PCYT1BCholine-phosphate cytidylyltransferase B isoform X1. (369 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (718 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC111169066Solute carrier family 22 member 2. (554 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
WASwiskott-Aldrich syndrome protein. (502 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (402 aa)
LOC111167637Solute carrier family 22 member 1 isoform X1. (568 aa)
SLC22A3Solute carrier family 22 member 3. (558 aa)
HRASGTPase HRas isoform X1. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
DGKDDiacylglycerol kinase. (1237 aa)
PCYT1ACholine-phosphate cytidylyltransferase A. (367 aa)
PLPP2LOW QUALITY PROTEIN: phospholipid phosphatase 2. (345 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
SLC44A4Choline transporter-like protein 4 isoform X1; Belongs to the CTL (choline transporter-like) family. (706 aa)
DGKGDiacylglycerol kinase. (835 aa)
DGKADiacylglycerol kinase. (762 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLD1Phospholipase. (1151 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (540 aa)
SP1Transcription factor Sp1. (786 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
DGKHDiacylglycerol kinase. (1247 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RHEBGTP-binding protein Rheb. (184 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
KRASGTPase KRas. (188 aa)
FOSProto-oncogene c-Fos. (380 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (871 aa)
TSC1Hamartin. (1169 aa)
SLC44A5Choline transporter-like protein 5 isoform X1; Belongs to the CTL (choline transporter-like) family. (714 aa)
PDGFCPlatelet-derived growth factor C isoform X2. (380 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DGKIDiacylglycerol kinase. (1079 aa)
PLA2G4FPhospholipase A2. (849 aa)
NRASGTPase NRas. (189 aa)
PLA2G4EPhospholipase A2. (868 aa)
RAC3Ras-related C3 botulinum toxin substrate 3 isoform X1. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
PRKCBProtein kinase C. (689 aa)
SLC22A5Solute carrier family 22 member 5 isoform X1. (691 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
DGKBDiacylglycerol kinase. (803 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (544 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (192 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SLC22A4Solute carrier family 22 member 4. (551 aa)
DGKZDiacylglycerol kinase. (1210 aa)
CHKACholine kinase alpha isoform X2. (611 aa)
PLD2Phospholipase. (933 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLA2G4APhospholipase A2. (749 aa)
TSC2Tuberin isoform X8. (1815 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
CHKBCholine/ethanolamine kinase isoform X1. (498 aa)
SLC5A7High affinity choline transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (592 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PLPP1Phospholipid phosphatase 1 isoform X1. (286 aa)
SLC44A1Choline transporter-like protein 1 isoform X1; Belongs to the CTL (choline transporter-like) family. (719 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (919 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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