STRINGSTRING
LAMA1 LAMA1 AGT AGT ADCY4 ADCY4 ADCY8 ADCY8 ITGA9 ITGA9 ADCY7 ADCY7 RYR2 RYR2 CACNB1 CACNB1 CACNA2D1 CACNA2D1 TPM4 TPM4 PRKACA PRKACA TPM3 TPM3 LMNA LMNA PLN PLN ITGA3 ITGA3 CACNA1S CACNA1S TNNT2 TNNT2 DMD DMD CACNA1F CACNA1F SGCB SGCB LAMA2 LAMA2 ACTB ACTB ITGA2B ITGA2B EMD EMD DES DES ITGB5 ITGB5 ITGA4 ITGA4 ITGAV ITGAV ADCY5 ADCY5 CACNB4 CACNB4 SLC8A3 SLC8A3 ADRB1 ADRB1 ITGB7 ITGB7 CACNB3 CACNB3 DAG1 DAG1 ITGB6 ITGB6 CACNA2D2 CACNA2D2 LOC111174776 LOC111174776 TNNC1 TNNC1 ADCY3 ADCY3 CACNA1D CACNA1D ITGA7 ITGA7 ITGA6 ITGA6 TTN TTN CACNA2D3 CACNA2D3 SGCG SGCG ADCY6 ADCY6 CACNA1C CACNA1C MYL3 MYL3 SLC8A1 SLC8A1 ITGA11 ITGA11 TGFB2 TGFB2 ITGA8 ITGA8 TGFB3 TGFB3 PRKACB PRKACB TPM1 TPM1 ITGA10 ITGA10 ITGB1 ITGB1 CACNB2 CACNB2 ADCY2 ADCY2 TGFB1 TGFB1 CACNG6 CACNG6 CACNG8 CACNG8 TNNI3 TNNI3 CACNG3 CACNG3 ITGB3 ITGB3 SLC8A2 SLC8A2 CACNG7 CACNG7 CACNG5 CACNG5 ACTG1 ACTG1 ACTC1 ACTC1 ITGB8 ITGB8 ATP2A1 ATP2A1 CACNG1 CACNG1 SGCD SGCD CACNG4 CACNG4 ADCY1 ADCY1 MYBPC3 MYBPC3 ATP2A3 ATP2A3 ADCY9 ADCY9 MYL2 MYL2 TPM2 TPM2 GNAS GNAS ITGA2 ITGA2 ITGA1 ITGA1 IGF1 IGF1 ATP2A2 ATP2A2 CACNG2 CACNG2 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMA1Laminin subunit alpha-1 isoform X1. (3081 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1237 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ITGA9Integrin alpha-9; Belongs to the integrin alpha chain family. (1035 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
RYR2Ryanodine receptor 2 isoform X1. (4965 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform X1. (597 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1097 aa)
TPM4Tropomyosin alpha-4 chain isoform X1; Belongs to the tropomyosin family. (284 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
TPM3Tropomyosin alpha-3 chain isoform X5; Belongs to the tropomyosin family. (284 aa)
LMNALamin; Belongs to the intermediate filament family. (664 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ITGA3Integrin alpha-3 isoform X1; Belongs to the integrin alpha chain family. (1068 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1868 aa)
TNNT2Troponin T, cardiac muscle isoform X1. (285 aa)
DMDDystrophin isoform X1. (3714 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1911 aa)
SGCBBeta-sarcoglycan. (329 aa)
LAMA2Laminin subunit alpha-2. (3008 aa)
ACTBActin, cytoplasmic 1. (375 aa)
ITGA2BIntegrin alpha-IIb; Belongs to the integrin alpha chain family. (1034 aa)
EMDEmerin isoform X1. (261 aa)
DESDesmin; Belongs to the intermediate filament family. (470 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
ITGAVIntegrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1262 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
SLC8A3Sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (920 aa)
ADRB1Beta-1 adrenergic receptor. (470 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (819 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
DAG1Dystroglycan. (895 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (808 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1. (1156 aa)
LOC111174776Tropomyosin alpha-3 chain-like. (185 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles isoform X1. (161 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
ITGA7Integrin alpha-7 isoform X1; Belongs to the integrin alpha chain family. (1141 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1091 aa)
TTNTitin. (32000 aa)
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X3. (1091 aa)
SGCGGamma-sarcoglycan isoform X1. (291 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2255 aa)
MYL3Myosin light chain 3. (199 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X7; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1004 aa)
ITGA11Integrin alpha-11; Belongs to the integrin alpha chain family. (1188 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ITGA8Integrin alpha-8 isoform X1; Belongs to the integrin alpha chain family. (1062 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
TPM1Tropomyosin alpha-1 chain isoform X19; Belongs to the tropomyosin family. (326 aa)
ITGA10Integrin alpha-10; Belongs to the integrin alpha chain family. (1167 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (604 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (255 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (496 aa)
TNNI3Troponin I, cardiac muscle isoform X1. (227 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit isoform X1. (315 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit isoform X1. (275 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
ACTC1Actin, alpha cardiac muscle 1. (377 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1006 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
SGCDDelta-sarcoglycan isoform X1. (299 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (375 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
MYBPC3Myosin-binding protein C, cardiac-type. (1313 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1057 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
TPM2Tropomyosin beta chain isoform X2; Belongs to the tropomyosin family. (314 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1023 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
ITGA1Integrin alpha-1; Belongs to the integrin alpha chain family. (1178 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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