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LOC114484769 LOC114484769 LOC112062886 LOC112062886 NUDT16 NUDT16 AK2 AK2 GUCY1A1 GUCY1A1 GUCY1B1 GUCY1B1 AK6 AK6 ADSS ADSS HDDC3 HDDC3 AMPD1 AMPD1 NT5C1A NT5C1A IMPDH1 IMPDH1 PNP PNP PDE10A PDE10A DCK DCK NUDT2 NUDT2 LOC102975756 LOC102975756 GMPS GMPS PDE7B PDE7B NME7 NME7 PDE11A PDE11A NT5C3A NT5C3A PDE1C PDE1C RRM2B RRM2B DCTD DCTD CTPS2 CTPS2 PDE7A PDE7A ENPP1 ENPP1 AK8 AK8 ENPP3 ENPP3 AK3 AK3 GUCY1A2 GUCY1A2 APRT APRT ADSS1 ADSS1 PDE5A PDE5A NT5C NT5C DGUOK DGUOK AK1 AK1 ENTPD6 ENTPD6 LOC102976077 LOC102976077 TK2 TK2 ATIC ATIC ADSL ADSL NME3 NME3 CMPK2 CMPK2 AK9-2 AK9-2 PDE1A PDE1A NTPCR NTPCR DCTPP1 DCTPP1 PDE3B PDE3B RRM2 RRM2 LOC112062924 LOC112062924 LOC112063121 LOC112063121 SLFN12 SLFN12 PDE3A PDE3A PDE9A PDE9A CMPK1 CMPK1 DTYMK DTYMK ENTPD4 ENTPD4 DUT DUT ENTPD2 ENTPD2 NME2 NME2 NME1 NME1 NT5E NT5E ENTPD8 ENTPD8 AK5 AK5 AMPD2 AMPD2 ENTPD3 ENTPD3 PDE2A PDE2A LOC102992058 LOC102992058 LOC102985101 LOC102985101 PDE1B PDE1B RRM1 RRM1 ADK ADK NT5C2 NT5C2 NT5C3B NT5C3B AK7 AK7 GMPR2 GMPR2 IMPDH2 IMPDH2 ENTPD5 ENTPD5 CANT1 CANT1 ENTPD1 ENTPD1 NME4 NME4 AK4 AK4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC114484769Adenylate kinase 4-like; Belongs to the adenylate kinase family. (143 aa)
LOC112062886Nucleoside diphosphate kinase. (154 aa)
NUDT16U8 snoRNA-decapping enzyme. (195 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-1 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (699 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1 isoform X3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (655 aa)
AK6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
ADSSAdenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
HDDC3guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase MESH1. (179 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (779 aa)
NT5C1ACytosolic 5'-nucleotidase 1A. (365 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (571 aa)
PNPPurine nucleoside phosphorylase. (96 aa)
PDE10APhosphodiesterase. (790 aa)
DCKDeoxycytidine kinase isoform X1. (376 aa)
NUDT2Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Belongs to the Nudix hydrolase family. (147 aa)
LOC102975756Hypoxanthine-guanine phosphoribosyltransferase-like. (227 aa)
GMPSGMP synthase [glutamine-hydrolyzing]. (693 aa)
PDE7BPhosphodiesterase. (500 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (377 aa)
PDE11APhosphodiesterase. (933 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
PDE1CPhosphodiesterase. (769 aa)
RRM2BRibonucleoside-diphosphate reductase subunit M2 B. (351 aa)
DCTDDeoxycytidylate deaminase. (178 aa)
CTPS2CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa)
PDE7APhosphodiesterase. (483 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
AK8Adenylate kinase 8 isoform X1; Belongs to the adenylate kinase family. (479 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (874 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (726 aa)
APRTAdenine phosphoribosyltransferase isoform X2. (180 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
PDE5APhosphodiesterase. (865 aa)
NT5C5'(3')-deoxyribonucleotidase, cytosolic type isoform X1. (214 aa)
DGUOKDeoxyguanosine kinase, mitochondrial isoform X2. (280 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (211 aa)
ENTPD6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (483 aa)
LOC102976077Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like. (165 aa)
TK2Thymidine kinase 2, mitochondrial. (120 aa)
ATICBifunctional purine biosynthesis protein PURH. (592 aa)
ADSLAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (514 aa)
NME3Nucleoside diphosphate kinase. (169 aa)
CMPK2UMP-CMP kinase 2, mitochondrial. (447 aa)
AK9-2Adenylate/nucleoside-diphosphate kinase. (294 aa)
PDE1APhosphodiesterase. (545 aa)
NTPCRCancer-related nucleoside-triphosphatase isoform X2. (190 aa)
DCTPP1dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (169 aa)
PDE3BPhosphodiesterase. (1117 aa)
RRM2Ribonucleoside-diphosphate reductase subunit M2 isoform X1. (408 aa)
LOC112062924CTP synthase 1-B-like. (150 aa)
LOC112063121Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (838 aa)
SLFN12Schlafen family member 12. (584 aa)
PDE3APhosphodiesterase. (1144 aa)
PDE9APhosphodiesterase. (532 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (313 aa)
DTYMKThymidylate kinase isoform X3. (212 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4 isoform X1; Belongs to the GDA1/CD39 NTPase family. (616 aa)
DUTDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X2. (167 aa)
ENTPD2LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (481 aa)
NME2Nucleoside diphosphate kinase. (152 aa)
NME1Nucleoside diphosphate kinase. (152 aa)
NT5E5'-nucleotidase; Belongs to the 5'-nucleotidase family. (574 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8 isoform X1; Belongs to the GDA1/CD39 NTPase family. (494 aa)
AK5Adenylate kinase isoenzyme 5; Belongs to the adenylate kinase family. (561 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (799 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
PDE2APhosphodiesterase. (941 aa)
LOC102992058Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
LOC102985101Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
PDE1BPhosphodiesterase. (516 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
ADKAdenosine kinase isoform X5. (362 aa)
NT5C2Cytosolic purine 5'-nucleotidase isoform X1. (573 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
AK7Adenylate kinase 7 isoform X1. (722 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (340 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5 isoform X1; Belongs to the GDA1/CD39 NTPase family. (428 aa)
CANT1Soluble calcium-activated nucleotidase 1 isoform X1. (401 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1 isoform X1; Belongs to the GDA1/CD39 NTPase family. (513 aa)
NME4Nucleoside diphosphate kinase. (187 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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