(57 nodes) RAB GEFs exchange GTP for GDP on RABs, and Protein prenyltransferase activity network (Physeter catodon)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

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textmining

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protein homology

Your Input:
	RAB6B	Ras-related protein Rab-6B. (208 aa)
	DENND1B	DENN domain-containing protein 1B isoform X5. (768 aa)
	CHML	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (655 aa)
	ENSPCTP00005002566	annotation not available (190 aa)
	DENND2A	DENN domain-containing protein 2A. (808 aa)
	RAB18	Ras-related protein Rab-18. (206 aa)
	RAB3GAP2	Rab3 GTPase-activating protein non-catalytic subunit isoform X1. (1392 aa)
	MICAL3	F-actin-monooxygenase MICAL3 isoform X16. (1073 aa)
	RAB3GAP1	Rab3 GTPase-activating protein catalytic subunit isoform X1. (982 aa)
	WDR41	WD repeat-containing protein 41 isoform X1. (472 aa)
	PTAR1	Protein prenyltransferase alpha subunit repeat-containing protein 1 isoform X3. (429 aa)
	GDI2	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (445 aa)
	RAB39A	Ras-related protein Rab-39A. (217 aa)
	RAB8A	Ras-related protein Rab-8A isoform X1. (413 aa)
	DENND5A	DENN domain-containing protein 5A. (1225 aa)
	RAB9B	Ras-related protein Rab-9B. (201 aa)
	RAB1A	Ras-related protein Rab-1A. (205 aa)
	ENSPCTP00005011209	annotation not available (374 aa)
	RAB21	Ras-related protein Rab-21. (222 aa)
	RHOBTB3	Rho-related BTB domain-containing protein 3. (615 aa)
	RAB12	Ras-related protein Rab-12. (327 aa)
	MICAL2	F-actin-monooxygenase MICAL2 isoform X2. (1944 aa)
	DENND1C	DENN domain-containing protein 1C. (793 aa)
	ENSPCTP00005015276	annotation not available (187 aa)
	RAB8B	Ras-related protein Rab-8B. (174 aa)
	DENND5B	DENN domain-containing protein 5B isoform X3. (1274 aa)
	BICD1	Protein bicaudal D homolog 1 isoform X2. (974 aa)
	RAB26	Ras-related protein Rab-26. (256 aa)
	RABEPK	Rab9 effector protein with kelch motifs isoform X1. (371 aa)
	ENSPCTP00005017017	annotation not available (213 aa)
	RILPL2	RILP-like protein 2 isoform X1. (205 aa)
	RILPL1	RILP-like protein 1 isoform X2. (403 aa)
	RAB1B	Ras-related protein Rab-1B. (201 aa)
	PLIN3	Perilipin; Belongs to the perilipin family. (438 aa)
	SMCR8	Guanine nucleotide exchange protein SMCR8. (787 aa)
	PPM1H	Protein phosphatase 1H. (515 aa)
	DENND1A	DENN domain-containing protein 1A isoform X7. (1026 aa)
	GDI1	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (432 aa)
	RABGAP1	Rab GTPase-activating protein 1 isoform X2. (1069 aa)
	RAB9A	Ras-related protein Rab-9A isoform X1. (201 aa)
	RAB13	Ras-related protein Rab-13. (203 aa)
	RAB29	Ras-related protein Rab-7L1 isoform X1. (203 aa)
	RAB39B	Ras-related protein Rab-39B. (213 aa)
	DENND4B	DENN domain-containing protein 4B isoform X1. (1504 aa)
	LOC114485397	DENN domain-containing protein 3-like isoform X1. (248 aa)
	DENND3	DENN domain-containing protein 3. (207 aa)
	RAB6A	Ras-related protein Rab-6A isoform X2. (208 aa)
	GCC2	GRIP and coiled-coil domain-containing protein 2. (1405 aa)
	EHBP1L1	EH domain-binding protein 1-like protein 1 isoform X2. (1497 aa)
	C9orf72	Guanine nucleotide exchange C9orf72 homolog isoform X1. (481 aa)
	CHM	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (653 aa)
	RAB28	Ras-related protein Rab-28 isoform X1. (221 aa)
	RABGGTB	Geranylgeranyl transferase type-2 subunit beta. (331 aa)
	PLEKHM2	Pleckstrin homology domain-containing family M member 2 isoform X5. (1028 aa)
	TBC1D20	TBC1 domain family member 20. (379 aa)
	RAB35	Ras-related protein Rab-35 isoform X1. (201 aa)
	RABGGTA	Geranylgeranyl transferase type-2 subunit alpha. (567 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BICD1	DENND5A	ENSPCTP00005016225	ENSPCTP00005010590	Protein bicaudal D homolog 1 isoform X2.	DENN domain-containing protein 5A.	0.438
BICD1	ENSPCTP00005015276	ENSPCTP00005016225	ENSPCTP00005015276	Protein bicaudal D homolog 1 isoform X2.	annotation not available	0.779
BICD1	RAB18	ENSPCTP00005016225	ENSPCTP00005004105	Protein bicaudal D homolog 1 isoform X2.	Ras-related protein Rab-18.	0.568
BICD1	RAB6A	ENSPCTP00005016225	ENSPCTP00005023305	Protein bicaudal D homolog 1 isoform X2.	Ras-related protein Rab-6A isoform X2.	0.779
BICD1	RAB6B	ENSPCTP00005016225	ENSPCTP00005000234	Protein bicaudal D homolog 1 isoform X2.	Ras-related protein Rab-6B.	0.779
C9orf72	RAB1A	ENSPCTP00005025681	ENSPCTP00005011068	Guanine nucleotide exchange C9orf72 homolog isoform X1.	Ras-related protein Rab-1A.	0.924
C9orf72	RAB39B	ENSPCTP00005025681	ENSPCTP00005022631	Guanine nucleotide exchange C9orf72 homolog isoform X1.	Ras-related protein Rab-39B.	0.962
C9orf72	RAB8A	ENSPCTP00005025681	ENSPCTP00005010173	Guanine nucleotide exchange C9orf72 homolog isoform X1.	Ras-related protein Rab-8A isoform X1.	0.920
C9orf72	SMCR8	ENSPCTP00005025681	ENSPCTP00005018632	Guanine nucleotide exchange C9orf72 homolog isoform X1.	Guanine nucleotide exchange protein SMCR8.	0.994
C9orf72	WDR41	ENSPCTP00005025681	ENSPCTP00005004996	Guanine nucleotide exchange C9orf72 homolog isoform X1.	WD repeat-containing protein 41 isoform X1.	0.993
CHM	CHML	ENSPCTP00005025713	ENSPCTP00005002140	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.519
CHM	DENND1A	ENSPCTP00005025713	ENSPCTP00005019542	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	DENN domain-containing protein 1A isoform X7.	0.481
CHM	DENND1B	ENSPCTP00005025713	ENSPCTP00005001979	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	DENN domain-containing protein 1B isoform X5.	0.447
CHM	DENND1C	ENSPCTP00005025713	ENSPCTP00005015156	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	DENN domain-containing protein 1C.	0.440
CHM	ENSPCTP00005002566	ENSPCTP00005025713	ENSPCTP00005002566	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	annotation not available	0.528
CHM	ENSPCTP00005011209	ENSPCTP00005025713	ENSPCTP00005011209	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	annotation not available	0.450
CHM	ENSPCTP00005015276	ENSPCTP00005025713	ENSPCTP00005015276	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	annotation not available	0.500
CHM	ENSPCTP00005017017	ENSPCTP00005025713	ENSPCTP00005017017	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	annotation not available	0.821
CHM	GDI1	ENSPCTP00005025713	ENSPCTP00005020148	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.450
CHM	GDI2	ENSPCTP00005025713	ENSPCTP00005006693	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.	0.450