(160 nodes) Spliceosomal complex network (Physeter catodon)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPCTP00005000030	annotation not available (98 aa)
	LOC114484084	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (92 aa)
	U2SURP	U2 snRNP-associated SURP motif-containing protein isoform X1. (1033 aa)
	SNRPG	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (74 aa)
	SF3B1	Splicing factor 3B subunit 1 isoform X1. (1304 aa)
	ZMAT2	Zinc finger matrin-type protein 2. (199 aa)
	RNPC3	RNA-binding region-containing protein 3 isoform X1. (517 aa)
	RBM22	pre-mRNA-splicing factor RBM22. (421 aa)
	SNRNP40	U5 small nuclear ribonucleoprotein 40 kDa protein. (358 aa)
	ZCCHC17	Nucleolar protein of 40 kDa. (230 aa)
	BCAS2	pre-mRNA-splicing factor SPF27. (240 aa)
	PPIE	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (316 aa)
	ENSPCTP00005002114	annotation not available (166 aa)
	SF3B5	Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
	SMU1	WD40 repeat-containing protein SMU1. (513 aa)
	PPIL3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	LOC112064003	PHD finger-like domain-containing protein 5A. (110 aa)
	DHX9	ATP-dependent RNA helicase A isoform X1. (1259 aa)
	LOC112061978	Ubiquitin-like protein 5. (71 aa)
	ENSPCTP00005003400	annotation not available (115 aa)
	TCERG1	Transcription elongation regulator 1 isoform X5. (1091 aa)
	SLU7	pre-mRNA-splicing factor SLU7 isoform X2. (631 aa)
	SNRPG-2	Small nuclear ribonucleoprotein G. (70 aa)
	PLRG1	Pleiotropic regulator 1 isoform X1. (513 aa)
	ENSPCTP00005004743	annotation not available (65 aa)
	SNIP1	Smad nuclear-interacting protein 1. (398 aa)
	ENSPCTP00005005145	annotation not available (108 aa)
	WDR53	WD repeat-containing protein 53 isoform X2. (373 aa)
	SF3A3	Splicing factor 3A subunit 3. (453 aa)
	PPIG	Peptidyl-prolyl cis-trans isomerase G. (750 aa)
	LOC102989765	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa)
	ENSPCTP00005006321	annotation not available (55 aa)
	RBM17	Splicing factor 45. (401 aa)
	CTNNBL1	Beta-catenin-like protein 1 isoform X1. (577 aa)
	USP39	U4/U6.U5 tri-snRNP-associated protein 2 isoform X1. (565 aa)
	ENSPCTP00005007052	annotation not available (188 aa)
	SNRPB	Small nuclear ribonucleoprotein-associated protein. (231 aa)
	SF3A1	Splicing factor 3A subunit 1. (793 aa)
	WBP4	WW domain-binding protein 4. (377 aa)
	SNRPF	Small nuclear ribonucleoprotein F. (86 aa)
	GPKOW	G-patch domain and KOW motifs-containing protein. (477 aa)
	SNRPA	U1 small nuclear ribonucleoprotein A isoform X1. (282 aa)
	ZMAT5	Zinc finger matrin-type protein 5 isoform X2. (170 aa)
	LOC102973429	Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (123 aa)
	CWF19L2	CWF19-like protein 2 isoform X1. (846 aa)
	CWC25	pre-mRNA-splicing factor CWC25 homolog. (425 aa)
	WDR25	WD repeat-containing protein 25. (270 aa)
	PQBP1	Polyglutamine-binding protein 1. (265 aa)
	ENSPCTP00005009370	annotation not available (55 aa)
	PRPF31	U4/U6 small nuclear ribonucleoprotein Prp31 isoform X2. (499 aa)
	ENSPCTP00005009576	annotation not available (228 aa)
	LOC102990906	pre-mRNA-splicing factor SYF2. (232 aa)
	LOC114487665	pre-mRNA-processing-splicing factor 8. (322 aa)
	ENSPCTP00005009879	annotation not available (174 aa)
	SRRM1	Serine/arginine repetitive matrix protein 1 isoform X9. (913 aa)
	CDC5L	Cell division cycle 5-like protein. (802 aa)
	ENSPCTP00005010337	annotation not available (120 aa)
	TFIP11	Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (784 aa)
	SNRNP200	U5 small nuclear ribonucleoprotein 200 kDa helicase. (1406 aa)
	SNRPB2	U2 small nuclear ribonucleoprotein B'. (225 aa)
	ENSPCTP00005011841	annotation not available (110 aa)
	ENSPCTP00005012098	annotation not available (54 aa)
	ENSPCTP00005012229	annotation not available (224 aa)
	SNRPN	Small nuclear ribonucleoprotein-associated protein. (244 aa)
	ENSPCTP00005012545	annotation not available (72 aa)
	ENSPCTP00005012574	annotation not available (111 aa)
	SNRNP70	U1 small nuclear ribonucleoprotein 70 kDa isoform X1. (439 aa)
	PRPF38A	pre-mRNA-splicing factor 38A. (312 aa)
	DDX23	Probable ATP-dependent RNA helicase DDX23. (818 aa)
	SRRM3	Serine/arginine repetitive matrix protein 3. (367 aa)
	PRPF3	U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1. (683 aa)
	DHX16	pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1. (1044 aa)
	ENSPCTP00005013941	annotation not available (74 aa)
	SF3B3	Splicing factor 3B subunit 3. (1217 aa)
	RBM10	RNA-binding protein 10 isoform X1. (931 aa)
	ENSPCTP00005014461	annotation not available (156 aa)
	CDC40	pre-mRNA-processing factor 17. (607 aa)
	RBM42	RNA-binding protein 42 isoform X1. (477 aa)
	WBP11	WW domain-binding protein 11 isoform X2. (641 aa)
	XAB2	pre-mRNA-splicing factor SYF1 isoform X1. (853 aa)
	PRPF4	U4/U6 small nuclear ribonucleoprotein Prp4 isoform X2. (521 aa)
	CWC22	pre-mRNA-splicing factor CWC22 homolog. (901 aa)
	PRPF18	pre-mRNA-splicing factor 18 isoform X2. (342 aa)
	DQX1	ATP-dependent RNA helicase DQX1. (719 aa)
	ENSPCTP00005015429	Small nuclear ribonucleoprotein polypeptide G. (94 aa)
	SF3B4	Splicing factor 3B subunit 4. (424 aa)
	CRNKL1	Crooked neck-like protein 1 isoform X1. (693 aa)
	DDX46	Probable ATP-dependent RNA helicase DDX46. (961 aa)
	DHX15	pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (795 aa)
	ENSPCTP00005016439	annotation not available (92 aa)
	CWC27	Spliceosome-associated protein CWC27 homolog isoform X1. (473 aa)
	PHF5A	PHD finger-like domain-containing protein 5A isoform X2. (114 aa)
	CWC15	Spliceosome-associated protein CWC15 homolog. (231 aa)
	PPWD1	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1. (641 aa)
	DHX8	ATP-dependent RNA helicase DHX8. (309 aa)
	PUF60	poly(U)-binding-splicing factor PUF60. (552 aa)
	ENSPCTP00005017426	annotation not available (203 aa)
	DDX42	ATP-dependent RNA helicase DDX42 isoform X1. (940 aa)
	SNRNP35	U11/U12 small nuclear ribonucleoprotein 35 kDa protein. (246 aa)
	SUGP1	SURP and G-patch domain-containing protein 1 isoform X1. (550 aa)
	PRPF8	pre-mRNA-processing-splicing factor 8. (1329 aa)
	ENSPCTP00005018382	annotation not available (217 aa)
	ENSPCTP00005018712	annotation not available (302 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
	PPIL2	RING-type E3 ubiquitin-protein ligase PPIL2 isoform X2. (591 aa)
	LOC102987342	Programmed cell death protein 7. (487 aa)
	DAW1	Dynein assembly factor with WDR repeat domains 1 isoform X1. (415 aa)
	ENSPCTP00005019744	annotation not available (68 aa)
	LOC102995785	E3 ubiquitin-protein ligase RNF113A-like. (335 aa)
	SMNDC1	Survival of motor neuron-related-splicing factor 30. (238 aa)
	ENSPCTP00005020616	annotation not available (49 aa)
	BUD31	Protein BUD31 homolog isoform X1. (149 aa)
	ENSPCTP00005021370	annotation not available (120 aa)
	LOC102981475	ATP-dependent RNA helicase DHX8 isoform X1. (927 aa)
	CHERP	Calcium homeostasis endoplasmic reticulum protein isoform X1. (925 aa)
	ENSPCTP00005021724	annotation not available (74 aa)
	SNRNP48	U11/U12 small nuclear ribonucleoprotein 48 kDa protein. (339 aa)
	ENSPCTP00005021776	annotation not available (72 aa)
	TXNL4A	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
	RBMX2	RNA-binding motif protein, X-linked 2. (327 aa)
	GCFC2	GC-rich sequence DNA-binding factor 2 isoform X4. (796 aa)
	WDR70	WD repeat-containing protein 70 isoform X1. (655 aa)
	YJU2	Splicing factor YJU2. (321 aa)
	SNRPC	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (159 aa)
	FUBP1	Far upstream element-binding protein 1 isoform X18. (655 aa)
	LOC114485130	U5 small nuclear ribonucleoprotein 200 kDa helicase-like. (595 aa)
	ISY1	pre-mRNA-splicing factor ISY1 homolog isoform X2. (299 aa)
	PRPF6	pre-mRNA-processing factor 6. (941 aa)
	SNRPD3	Small nuclear ribonucleoprotein Sm D3. (178 aa)
	LOC114483901	Leucine-rich repeat-containing protein 51-like. (54 aa)
	SNRPA1	U2 small nuclear ribonucleoprotein A. (255 aa)
	ZCRB1	Zinc finger CCHC-type and RNA-binding motif-containing protein 1 isoform X1. (217 aa)
	SF3B6	Splicing factor 3B subunit 6. (132 aa)
	DHX35	Probable ATP-dependent RNA helicase DHX35 isoform X2. (703 aa)
	BUD13	BUD13 homolog. (676 aa)
	DHX38	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1. (1227 aa)
	TXNL4B	Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa)
	EFTUD2	116 kDa U5 small nuclear ribonucleoprotein component. (975 aa)
	SNRPE	Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa)
	ENSPCTP00005026871	annotation not available (125 aa)
	LOC102994985	Splicing factor 3A subunit 2. (198 aa)
	IK	Protein Red. (553 aa)
	LOC114483883	Leucine-rich repeat-containing protein 51-like isoform X1. (166 aa)
	YBX1	Nuclease-sensitive element-binding protein 1 isoform X3. (324 aa)
	PPIL1	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
	PPIH	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (177 aa)
	SRRM2	Serine/arginine repetitive matrix protein 2 isoform X1. (2736 aa)
	UBL5	Ubiquitin-like protein 5 isoform X2. (256 aa)
	MFAP1	Microfibrillar-associated protein 1. (439 aa)
	ENSPCTP00005029299	annotation not available (79 aa)
	SNRPD1	Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa)
	ENSPCTP00005029835	annotation not available (123 aa)
	AQR	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1485 aa)
	RNF113A	E3 ubiquitin-protein ligase RNF113A. (344 aa)
	ENSPCTP00005030204	annotation not available (66 aa)
	PRPF19	pre-mRNA-processing factor 19. (504 aa)
	ENSPCTP00005031714	annotation not available (98 aa)
	SART1	U4/U6.U5 tri-snRNP-associated protein 1. (801 aa)
	SF3B2	Splicing factor 3B subunit 2 isoform X2. (895 aa)
	SNW1	SNW domain-containing protein 1. (578 aa)

Your Current Organism:

Physeter catodon

NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQR	BCAS2	ENSPCTP00005029975	ENSPCTP00005001604	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	pre-mRNA-splicing factor SPF27.	0.953
AQR	BUD13	ENSPCTP00005029975	ENSPCTP00005026469	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	BUD13 homolog.	0.551
AQR	BUD31	ENSPCTP00005029975	ENSPCTP00005021369	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	Protein BUD31 homolog isoform X1.	0.995
AQR	CDC40	ENSPCTP00005029975	ENSPCTP00005014738	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	pre-mRNA-processing factor 17.	0.979
AQR	CDC5L	ENSPCTP00005029975	ENSPCTP00005010224	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	Cell division cycle 5-like protein.	0.988
AQR	CRNKL1	ENSPCTP00005029975	ENSPCTP00005015714	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	Crooked neck-like protein 1 isoform X1.	0.997
AQR	CTNNBL1	ENSPCTP00005029975	ENSPCTP00005006795	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	Beta-catenin-like protein 1 isoform X1.	0.532
AQR	CWC15	ENSPCTP00005029975	ENSPCTP00005016937	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	Spliceosome-associated protein CWC15 homolog.	0.939
AQR	CWC22	ENSPCTP00005029975	ENSPCTP00005014937	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	pre-mRNA-splicing factor CWC22 homolog.	0.899
AQR	CWC25	ENSPCTP00005029975	ENSPCTP00005008924	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	pre-mRNA-splicing factor CWC25 homolog.	0.541
AQR	CWC27	ENSPCTP00005029975	ENSPCTP00005016714	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	Spliceosome-associated protein CWC27 homolog isoform X1.	0.648
AQR	CWF19L2	ENSPCTP00005029975	ENSPCTP00005008600	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	CWF19-like protein 2 isoform X1.	0.884
AQR	DHX15	ENSPCTP00005029975	ENSPCTP00005016177	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15.	0.796
AQR	DHX16	ENSPCTP00005029975	ENSPCTP00005013865	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1.	0.705
AQR	DHX35	ENSPCTP00005029975	ENSPCTP00005026210	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	Probable ATP-dependent RNA helicase DHX35 isoform X2.	0.557
AQR	DHX38	ENSPCTP00005029975	ENSPCTP00005026474	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1.	0.581
AQR	DHX8	ENSPCTP00005029975	ENSPCTP00005017211	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	ATP-dependent RNA helicase DHX8.	0.880
AQR	DHX9	ENSPCTP00005029975	ENSPCTP00005003248	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	ATP-dependent RNA helicase A isoform X1.	0.416
AQR	DQX1	ENSPCTP00005029975	ENSPCTP00005015210	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	ATP-dependent RNA helicase DQX1.	0.476
AQR	EFTUD2	ENSPCTP00005029975	ENSPCTP00005026782	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.	116 kDa U5 small nuclear ribonucleoprotein component.	0.978