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PDE8A PDE8A PLCE1 PLCE1 PDE6C PDE6C PDE4B PDE4B PDE4C PDE4C PDE6G PDE6G SMG8 SMG8 APEX1 APEX1 PDE1B PDE1B FAN1 FAN1 PLCXD3 PLCXD3 PDE2A PDE2A PLCD4 PLCD4 APEX2 APEX2 SMPD1 SMPD1 PLD2 PLD2 PLCG2 PLCG2 PLEKHD1 PLEKHD1 SMPD3 SMPD3 GPLD1 GPLD1 TDP2 TDP2 PLCB3 PLCB3 PDE9A PDE9A GDPD3 GDPD3 PDE3A PDE3A PLCD3 PLCD3 PLCG1 PLCG1 PLCZ1 PLCZ1 ADPRM ADPRM PDE3B PDE3B NAPEPLD NAPEPLD PLD1 PLD1 PLCL2 PLCL2 PLCH2 PLCH2 PLCL1 PLCL1 PDE6A PDE6A LOC114487532 LOC114487532 GDPD5 GDPD5 ENPP2 ENPP2 PDE1A PDE1A TDP1 TDP1 SMPD4 SMPD4 SMPD2 SMPD2 PDE6H PDE6H SMPDL3A SMPDL3A ENPP6 ENPP6 PLCB1 PLCB1 PDE4D PDE4D PDE6B PDE6B GDPD4 GDPD4 CNP CNP MPPE1 MPPE1 GPCPD1 GPCPD1 GDPD2 GDPD2 ENSPCTP00005011680 ENSPCTP00005011680 PDE5A PDE5A ENSPCTP00005009245 ENSPCTP00005009245 LOC102986245 LOC102986245 PLCB4 PLCB4 ENPP3 ENPP3 ENPP1 ENPP1 PDE7A PDE7A PLD6 PLD6 PLCD1 PLCD1 SMPDL3B SMPDL3B PDE1C PDE1C PDE11A PDE11A PDE8B PDE8B PDE7B PDE7B PLCH1 PLCH1 PDE10A PDE10A GDE1 GDE1 ENPP7 ENPP7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE8APhosphodiesterase. (831 aa)
PLCE1Phosphoinositide phospholipase C. (2286 aa)
PDE6CPhosphodiesterase. (860 aa)
PDE4BPhosphodiesterase. (735 aa)
PDE4CPhosphodiesterase. (710 aa)
PDE6GRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma. (87 aa)
SMG8Protein SMG8. (1016 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
PDE1BPhosphodiesterase. (516 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1023 aa)
PLCXD3PI-PLC X domain-containing protein 3. (321 aa)
PDE2APhosphodiesterase. (941 aa)
PLCD4Phosphoinositide phospholipase C. (793 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (515 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa)
PLD2Phospholipase. (929 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PLEKHD1Pleckstrin homology domain-containing family D member 1. (506 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (653 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (839 aa)
TDP2tyrosyl-DNA phosphodiesterase 2 isoform X1. (362 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PDE9APhosphodiesterase. (532 aa)
GDPD3Lysophospholipase D GDPD3 isoform X2. (318 aa)
PDE3APhosphodiesterase. (1144 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1165 aa)
PLCZ1Phosphoinositide phospholipase C. (640 aa)
ADPRMManganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X7. (341 aa)
PDE3BPhosphodiesterase. (1117 aa)
NAPEPLDN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1. (478 aa)
PLD1Phospholipase. (1180 aa)
PLCL2Phosphoinositide phospholipase C. (1127 aa)
PLCH2Phosphoinositide phospholipase C. (1116 aa)
PLCL1Phosphoinositide phospholipase C. (1096 aa)
PDE6APhosphodiesterase. (861 aa)
LOC114487532cAMP-specific 3',5'-cyclic phosphodiesterase 4B-like; Belongs to the cyclic nucleotide phosphodiesterase family. (357 aa)
GDPD5Glycerophosphodiester phosphodiesterase domain-containing protein 5 isoform X3. (605 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. (915 aa)
PDE1APhosphodiesterase. (545 aa)
TDP1tyrosyl-DNA phosphodiesterase 1 isoform X1. (603 aa)
SMPD4Sphingomyelin phosphodiesterase 4 isoform X1. (927 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (423 aa)
PDE6HRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma. (83 aa)
SMPDL3AAcid sphingomyelinase-like phosphodiesterase. (453 aa)
ENPP6Ectonucleotide pyrophosphatase/phosphodiesterase family member 6. (440 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PDE4DPhosphodiesterase. (807 aa)
PDE6BPhosphodiesterase. (854 aa)
GDPD4Glycerophosphodiester phosphodiesterase domain-containing protein 4. (647 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (420 aa)
MPPE1Metallophosphoesterase 1 isoform X4. (402 aa)
GPCPD1Glycerophosphocholine phosphodiesterase GPCPD1 isoform X1. (672 aa)
GDPD2Glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1. (513 aa)
ENSPCTP00005011680annotation not available (46 aa)
PDE5APhosphodiesterase. (865 aa)
ENSPCTP00005009245annotation not available (124 aa)
LOC102986245Phosphodiesterase. (627 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (874 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
PDE7APhosphodiesterase. (483 aa)
PLD6Mitochondrial cardiolipin hydrolase. (316 aa)
PLCD1Phosphoinositide phospholipase C. (781 aa)
SMPDL3BAcid sphingomyelinase-like phosphodiesterase 3b isoform X2. (457 aa)
PDE1CPhosphodiesterase. (769 aa)
PDE11APhosphodiesterase. (933 aa)
PDE8BPhosphodiesterase. (841 aa)
PDE7BPhosphodiesterase. (500 aa)
PLCH1Phosphoinositide phospholipase C. (1695 aa)
PDE10APhosphodiesterase. (790 aa)
GDE1Glycerophosphodiester phosphodiesterase 1 isoform X1. (331 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase family member 7. (458 aa)
Your Current Organism:
Physeter catodon
NCBI taxonomy Id: 9755
Other names: P. catodon, Physeter macrocephalus, sperm whale
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